Preparation and preliminary quality evaluation of aspirin/L-glutamate compound pellets

Abstract

L-glutamate is an important component of protein. It can prevent gastrointestinal damage caused by NSAIDs. We constructed two-phase enteric-coated granules of aspirin and L-glutamate compound by extrusion spheronization method and fluidized bed coating. The subliminal effective dose of L-glutamate is 100 mg/kg tested by model of gastric ulcer of rats induced by aspirin and drug administration. HPLC-UV and UV–Vis methods were adopted to determine content and cumulative release of aspirin and L-glutamate as quality analysis method indexes. The prescription and process optimization were carried out with yield, sphericity and dissolution. The two-phase compound granules have good sphericity of 0.93 ± 0.05 (aspirin pellets) and 0.94 ± 0.02 (L-glutamate pellets), content of salicylic acid (0.24 ± 0.03)%, dissolution of aspirin (2.36 ± 0.11)%. Quality evaluation and preliminary stability meet the commercial requirements. The stored environment of compound preparation should be sealed in a cool and dark place.

Involvement of microRNA/cystine/glutamate transporter in cold-stressed gastric mucosa injury

“…Recent studies have shown that glutamate plays an important role in the protection and repair of gastric mucous injuries ( Du et al, 2014 ; Du et al, 2020 ; Xu et al, 2021 ). Glutamate, an important endogenous active substance, is widely present in the central nervous system and peripheral tissues.…”