Preparation, characterization and anti-inflammatory effects of curcumin loaded carboxymethyl cellulose acetate butyrate nanoparticles on adjuvant induced arthritis in rats

Dewangan, Ashish; Perumal, Yamini; Pavurala, Naresh; Chopra, Kanwaljit; Mazumder, Sonal

doi:10.1016/j.jddst.2017.07.022

Cited by 48 publications

(25 citation statements)

References 36 publications

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“…For X-ray assessment, the animals were anesthetized by intraperitoneal injection of 40 mg/kg sodium thiopental and images of the right ankle joint were taken at 10 mA, 48 kV and 0.25 s of exposure using X-ray machine (GE Radiography System). During the imaging, animals were placed on X-ray plate and radiographed at a 25 cm focus to film distance for the evaluation of soft tissue swelling, narrowing of the joint space (loss of cartilage), destruction of bone (erosions) and articular surface regularity [24].…”

Section: Radiographic (X-ray) Analysismentioning

confidence: 99%

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Rao

Aziz

Roome

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Nanomedicines anticipate drug delivery to inflamed tissues in rheumatoid arthritis (RA) with greater efficacy and lesser side effects. This study investigates the anti-arthritic potentials of Hesperidin (HP) loaded in gum acacia (GA) stabilized green silver nanoparticles (AgNPs). Synthesized GA-AgNPs were characterized through UV-vis spectrophotometer, zetasizer and atomic force microscope (AFM). The HP and its loaded NPs were tested for RA in Complete Freund's adjuvant (CFA) induced arthritis model. GA-AgNPs were found in nano-range size with negative charge, spherical shape and loaded increased HP amount. HP loaded GA-AgNPs showed minimal arthritic score exhibiting mild to moderate tissue swelling, reduced degenerative changes along with mild articular changes. Histopathological analysis revealed comparatively lesser influx of inflammatory cells and diminished granulamatous inflammation in ankle joints tissues in the presence of HP loaded GA-AgNPs. RT-PCR revealed that HP loaded GA-AgNPs significantly reduced the TLRs mRNA expression. Results validate GA stabilized green AgNPs as stable nano-cargos for targeted delivery of HP for restoring the progression of RA.

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Section: Radiographic (X-ray) Analysismentioning

confidence: 99%

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Rao

Aziz

Roome

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…It is one of the most studied and most popular natural products of the past decade. Curcumin has been demonstrated to have extensive pharmacological activities including antioxidation 13 , anti-inflammation 14 , 15 , 16 , anticancer 17 , antimicrobial 18 , and immunoregulation. 19 Curcumin inhibits the proliferation and migration of A549 lung cancer cells and enhances apoptosis 20 , 21 .…”

Section: Introductionmentioning

confidence: 99%

Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers

Zhang

Chen

et al. 2018

Acta Pharmaceutica Sinica B

154

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Lung cancer is the leading cause of cancer-related deaths. Traditional chemotherapy causes serious toxicity due to the wide bodily distribution of these drugs. Curcumin is a potential anticancer agent but its low water solubility, poor bioavailability and rapid metabolism significantly limits clinical applications. Here we developed a liposomal curcumin dry powder inhaler (LCD) for inhalation treatment of primary lung cancer. LCDs were obtained from curcumin liposomes after freeze-drying. The LCDs had a mass mean aerodynamic diameter of 5.81 μm and a fine particle fraction of 46.71%, suitable for pulmonary delivery. The uptake of curcumin liposomes by human lung cancer A549 cells was markedly greater and faster than that of free curcumin. The high cytotoxicity on A549 cells and the low cytotoxicity of curcumin liposomes on normal human bronchial BEAS-2B epithelial cells yielded a high selection index partly due to increased cell apoptosis. Curcumin powders, LCDs and gemcitabine were directly sprayed into the lungs of rats with lung cancer through the trachea. LCDs showed higher anticancer effects than the other two medications with regard to pathology and the expression of many cancer-related markers including VEGF, malondialdehyde, TNF-α, caspase-3 and BCL-2. LCDs are a promising medication for inhalation treatment of lung cancer with high therapeutic efficiency.

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“…The addition of curcumin-loaded nanocapsules produced from the Eudragit L-100 polymer to the diets of dairy sheeps resulted in a higher antioxidant capacity and lower lipid peroxidation in their milk (Jaguezeski et al, 2019). Anti-inflammatory activities of different curcumin-loaded nanocomposites were also repeatedly reported (Wang et al, 2015a;Ameruoso et al, 2017;Dewangan et al, 2017;El-Naggar et al, 2019).…”

Section: Nano-curcuminmentioning

confidence: 86%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

149

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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Preparation, characterization and anti-inflammatory effects of curcumin loaded carboxymethyl cellulose acetate butyrate nanoparticles on adjuvant induced arthritis in rats

Cited by 48 publications

References 36 publications

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

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