Preparation, characterization and antibacterial activity of O -acetyl-chitosan- N -2-hydroxypropyl trimethyl ammonium chloride

Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

“…[188][189][190][191][192] A recent study with docetaxel showed that HACC-modified chitosan administered orally exhibits a higher drug bioavailability via various absorption mechanisms including transcellular, paracellular and M cell uptake. 193 Interestingly, the study also found that HACC-modified SLNs showed a higher uptake of the drug in the Peyer's Patches than normal cells.…”

<i>In vivo</i> study of antifungal effects of low-molecular-weight chitosan against <i>Candida albicans </i>

“…Chitosan is a cationic polysaccharide with a positive charge that can react with the negatively charged cell walls of microorganisms and can damage the targeted cells, causing loss of cell membrane. It prevents the development of fungal diseases by preventing formation and maturation of biofilm and preventing the attachment of C. albicans to human mucosal cells (33)(34)(35). The positive electrical charge of chitosan that targets the negative charge of the fungal membrane, increases the permeability of the membrane, and eventually leads to leakage of cells and their death.…”

“…It has been reported that a decrease in the molecular weight of chitosan is associated with an increase in its antifungal efficacy (24,31,35,(38)(39)(40)(41)(42). Low-molecular-weight chitosan is water soluble, whereas high-molecular-weight chitosans are soluble in acidic water solutions.…”

Synthesis and Characterization of O-Acetyl-chitosan Acetic Ester

“…A representative microbe colony was picked off with an inoculating needle, placed in 25 mL sterile nutrient broth, and then incubated in a shaker at a speed of 100 rpm at 37°C for 24 h. The bacterial suspension was then diluted with sterile physiological saline to 10 3 -10 4 CFU/mL and used for the antibacterial test [21,22]. The inhibition rates of CS and ACHA against E. coli, S. aureus, and P. aeruginosa were determined through the use of agar plates [1]. The main solution of CS and ACHA was prepared by dissolving the materials in 1% (w/v) acetic acid aqueous solution, respectively.…”

“…Nowadays, antibacterial agents derived from natural substance have attracted enormous attention, due to their excellent antibacterial efficiency and favorable biocompatibility [1]. In addition to their own structural characteristics, the stability and durability of natural antibacterial agents are primary factors restricting their wide applications [2,3].…”