Preparation, Characterization, and Antimicrobial Properties of Chitosan–Silver Nanocomposites Films Against Fish Pathogenic Bacteria and Fungi

Dananjaya, S.H.S.; Kulatunga, D. C. M.; Godahewa, G.I.; Nikapitiya, Chamilani; Oh, Chulhong; Edussuriya, M.; Lee, Jehee; Zoysa, Mahanama De

doi:10.1007/s12088-017-0670-4

Cited by 14 publications

(7 citation statements)

References 36 publications

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“…For example, Liu, et al [65] reported that surface grafting of gentamicin molecules improved antibacterial chitosan properties [65]. In another study, chitosan films incorporated with Ag nanoparticles exhibited enhanced antimicrobial properties (Figure 6) [66]. Chitosan's wound-healing properties are enhanced in Ag-chitosan.…”

Section: Chemical Modifications On Chitin and Chitosan Surfaces: Deve...mentioning

confidence: 97%

Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair

Ferreira

Silva

et al. 2022

Pharmaceutics

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Chitosan displays a dual function, acting as both an active ingredient and/or carrier for pharmaceutical bioactive molecules and metal ions. Its hydroxyl- and amino-reactive groups and acetylation degree can be used to adjust this biopolymer’s physicochemical and pharmacological properties in different forms, including scaffolds, nanoparticles, fibers, sponges, films, and hydrogels, among others. In terms of pharmacological purposes, chitosan association with different polymers and the immobilization or entrapment of bioactive agents are effective strategies to achieve desired biological responses. Chitosan biocompatibility, water entrapment within nanofibrils, antioxidant character, and antimicrobial and anti-inflammatory properties, whether enhanced by other active components or not, ensure skin moisturization, as well as protection against bacteria colonization and oxidative imbalance. Chitosan-based nanomaterials can maintain or reconstruct skin architecture through topical or systemic delivery of hydrophilic or hydrophobic pharmaceuticals at controlled rates to treat skin affections, such as acne, inflammatory manifestations, wounds, or even tumorigenesis, by coating chemotherapy drugs. Herein, chitosan obtention, physicochemical characteristics, chemical modifications, and interactions with bioactive agents are presented and discussed. Molecular mechanisms involved in chitosan skin protection and recovery are highlighted by overlapping the events orchestrated by the signaling molecules secreted by different cell types to reconstitute healthy skin tissue structures and components.

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Section: Chemical Modifications On Chitin and Chitosan Surfaces: Deve...mentioning

confidence: 97%

Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair

Ferreira

Silva

et al. 2022

Pharmaceutics

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“…Antibacterial activity: The agar disc diffusion method was employed for the determination of the antibacterial activity of the Ag-CS-AA NC 28 . Agar medium (Mueller-Hinton) was prepared by adding beef infusion solids (0.2 g), starch (15 g), casein hydrolysate (1.75 g) and agar (1.7 g) in 100 mL distilled water.…”

Section: X-ray Photoelectron Spectroscopy (Xps)mentioning

confidence: 99%

Silver/Chitosan/Ascorbic Acid Nanocomposites Attenuates Bacterial Sepsis in Cecal Ligation and Puncture Rat Model

Moha¹,

Al-Quraish²,

Abdel-Gabe³

et al. 2021

International J. of Pharmacology

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Background and Objective: Sepsis is a universal that represents a physiologic, pathologic and biochemical abnormalities disorder stimulated by infection. The present study aimed to synthesize and apply silver/chitosan/ascorbic acid Nanocomposites (Ag-CS-AA NC) on septic rats induced by cecal ligation and puncture. Materials and Methods: The synthesized Ag-CS-AA NC were characterized by UV-visible spectroscopy, XRD, XPS, FTIR and TEM. H 2 O 2 scavenging and antibacterial activities of Ag-CS-AA NC were analyzed. Eighteen rats were randomly divided into three groups: Sham group, CLP-induced sepsis and septic rats treated with Ag-CS-AA NC. Results: The synthesized Ag-CS-AA NC showed in vitro potent antioxidant and antibacterial activities against Gram-positive and Gram-negative bacteria. Ag-CS-AA NC administration to septic rats showed a reduction in alanine aminotransferases, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyltransferase and concentrations of total proteins, albumin, creatinine, urea, uric acid, nitric oxide, while glutathione reduced and catalase increased. The histopathological investigation showed clear improvement in the hepatic and kidney architecture. Conclusion: The data provide the first experimental demonstration that green synthesize Ag-CS-AA NC has a therapeutic effect against sepsis-induced liver and kidney damage through its antibacterial and antioxidant activities.

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“…For example, Liu et al postulated that the surface grafting of gentamicin molecules improved the antibacterial properties of CS [59]. Dananjaya et al developed AgNP-(Ag nanoparticle-) embedded chitosan films with more optimal antimicrobial properties [60].…”

Section: Antibacterial Performancementioning

confidence: 99%

Recent Advances in Chitosan‐Based Metal Nanocomposites for Wound Healing Applications

Wang

et al. 2020

Advances in Materials Science and Engineering

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Chitosan (CS) has been extensively studied as a natural polymer, in the field of wound repair, due to its useful properties, which include a lack of toxicity and stimulation, excellent biological affinity, degradability, and promotion of collagen deposition. However, inferior mechanical strength and moderate antibacterial properties are the drawbacks restricting its further clinical application. Many researchers have adopted the use of nanotechnology, in particular metallic nanoparticles (MNPs), in order to improve the mechanical strength and specific antibacterial properties of chitosan composites, with promising results. Furthermore, chitosan naturally functions as a reducing agent for MNPs, which can also reduce cytotoxicity. Thus, CS, in combination with MNPs, exhibits antibacterial activity, excellent mechanical strength, and anti-inflammatory properties, and it has great potential to accelerate the process of wound healing. This review discusses the current use of CS and MNPs in wound healing and emphasises the synergy and the advantages for various applications in wound healing.

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Preparation, Characterization, and Antimicrobial Properties of Chitosan–Silver Nanocomposites Films Against Fish Pathogenic Bacteria and Fungi

Cited by 14 publications

References 36 publications

Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair

Chitosans and Nanochitosans: Recent Advances in Skin Protection, Regeneration, and Repair

Silver/Chitosan/Ascorbic Acid Nanocomposites Attenuates Bacterial Sepsis in Cecal Ligation and Puncture Rat Model

Recent Advances in Chitosan‐Based Metal Nanocomposites for Wound Healing Applications

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