Preparation, Characterization, and Biological Activity Against Artemia Salina of News Copolymer PMMA‐g‐PEG Derivatives Incorporated With Fluconazole

Abstract

The graft copolymer PMMA‐g‐PEG meets characteristics of their origin polymers: PMMA resistance and transparency and appropriate structure, including good solubility in water and organic solvents, lack of toxicity, and easy processing of the PEG, with inserted between the pharmacologically active polymers and can act as drugs or may be used as carriers for other drugs. The PMMA‐G‐PEG copolymer and their derivatives are synthesized previously and subsequently, the copolymer derivatives passed through the process of emulsification and incorporation of the drug fluconazole. Emulsified and Incorporated derivatives copolymers are characterized by Fourier‐transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential thermal analysis (DTA), X‐ray diffraction (XRD), and scanning electron microscopy (SEM) after the incorporation, in order to evaluate their effectiveness. The efficiency of incorporation is evaluated as well as the influence of polymer chain complexity in the incorporated fluconazole. Their toxicities are determined against Artemia salina Leach. The LD50 values have also been obtained for these copolymers.

Novel Fe3O4 Nanoparticles with Bioactive Glass–Naproxen Coating: Synthesis, Characterization, and In Vitro Evaluation of Bioactivity

“…The ATR-FTIR spectra of the samples before and after naproxen loading are shown and compared in Figure 7. In the naproxen spectrum (Figure 7 (a)), it is possible to identify: (i) a broad band at about 3200 cm −1 assigned to the -OH stretching of -COOH group; (ii) the characteristic absorption peaks at 1681 and 1725 cm −1 , which are assigned to the carbonyl stretch of the carboxylic acid group, where the former wavenumber represents the hydrogen-bonded carbonyl group and the latter the free carbonyl group; and (iii) a peak due to aromatic stretching positioned at 1604 cm −1 [57][58][59].…”