Preparation, characterization, and encapsulation/release studies of a composite nanofiber mat electrospun from an emulsion containing poly(lactic-co-glycolic acid)

Liao, Yiliang; Zhang, Lifeng; Gao, Yi; Zhu, Zhengtao; Fong, Hao

doi:10.1016/j.polymer.2008.09.045

Cited by 77 publications

(55 citation statements)

References 23 publications

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“…Nanofibers obtained by electrospining are structurally homogeneous and are unlikely to encapsulate bioactive agents as nano-scaled particles. Recently, electrospinning of emulsions has produced composite nanofibers with nano-scaled drug particles surrounded/coated by emulsifiers/surfactants and impregnated in biocompatible and/or biodegradable polymers (Liao et al 2008). Such a type of composite nanofiber mats possesses the characteristics of a controllable drug encapsulation/release vehicle.…”

Section: Introductionmentioning

confidence: 99%

“…A composite nanofiber mat was prepared by electrospinning from an emulsion made of PLGA, Rhodamine B, sorbitan monooleate (Span-80), chloroform, N,N-dimethylformamide (DMF), and distilled water, as in (Liao et al 2008). PLGA has been well recognized for its suitability in drug delivery due to its good biocompatibility and ability to achieve a complete drug release as a result of degradation and erosion of the polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

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A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

Kojić¹,

Milošević²,

Simić³

et al. 2017

JSSCM

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The aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D,L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numerical examples.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

Kojić¹,

Milošević²,

Simić³

et al. 2017

JSSCM

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“…Another route towards achieving a core/shell morphology is to employ an emulsion as the precursor solution, [90][91][92][93][94] Fig. 4C.…”

mentioning

confidence: 99%

Designing electrospun nanofiber mats to promote wound healing – a review

2013

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Current strategies to treat chronic wounds offer limited relief to the 7.75 million patients who suffer from burns or chronic skin ulcers. Thus, as long as chronic wounds remain a global healthcare problem, the development of alternate treatments remain desperately needed. This review explores the recent strategies employed to tailor electrospun nanofiber mats towards accelerating the wound healing process. Porous nanofiber mats readily produced by the electrospinning process offer a promising solution to the management of wounds. The matrix chemistry, surface functionality, and mat degradation rate all can be fine-tuned to govern the interactions that occur at the materials-biology interface. In this review, first we briefly discuss the wound healing process and then highlight recent advances in drug release, biologics encapsulation, and antibacterial activity that have been demonstrated via electrospinning. While this versatile biomaterial has shown much progress, commercializing nanofiber mats that fully address the needs of an individual patient remains an ambitious challenge.

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“…Various types of nanomaterials have been introduced in polymer blends for electrospinning: encapsulated hydrophobic liquids [3,4,5,6], cellulose nanofibrils [7], dye [8] and nanoparticles [9]. On the other hand, the introduction of micron-size particles in electrospun blends is new and potentially of high interest, and only a very limited amount of work can be found in the literature.…”

Section: Introductionmentioning

confidence: 99%

Needleless electrospun nanofibers containing microcapsules: a methodology for self-supported microcontainers

Grandcolas¹,

Sunde²,

Pilz³

et al. 2017

IJERA

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The present paper investigates the facile production of electrospun polyvinyl alcohol (PVA) nanofibers containing either micro-sized polymer or hybrid capsules, using a needleless electrospinning system. Oilcontaining microcapsules with diameters of around 3 or 10 µm, respectively, were produced via an oil-in-water miniemulsion and mixed with a PVA solution. Appropriate adjustment of electrospinning parameters enabled a controlled assembly of PVA nanofibers into a network containing microcapsules, without damaging their integrity. The PVA nanofibers have diameters in a range of 200-300 nm and showed good homogeneity. The introduction of microcapsules caused an increase in the PVA nanofiber diameters probably due to an increase in the solution viscosity. The production of such self-supported and loaded microcontainers could be of high interest for various applications.

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Preparation, characterization, and encapsulation/release studies of a composite nanofiber mat electrospun from an emulsion containing poly(lactic-co-glycolic acid)

Cited by 77 publications

References 23 publications

A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

A Radial 1d Finite Element for Drug Release From Drug Loaded Nanofibers

Designing electrospun nanofiber mats to promote wound healing – a review

Needleless electrospun nanofibers containing microcapsules: a methodology for self-supported microcontainers

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