Preparation, characterization and in vitro assessment of ibuprofen loaded calcium phosphate/gypsum bone cements

Alexopoulou, Maria; Mystiridou, Emmanouela; Mouzakis, Dionysios E.; Zaoutsos, Stefanos; Fatouros, Dimitrios G.; Bouropoulos, Nikolaos

doi:10.1002/crat.201500143

Cited by 27 publications

(14 citation statements)

References 32 publications

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“…All these criteria are well met by CaPs and their composites. In order to make the implant antibacterial, various antibiotics have been incorporated in CaPs [ 510 , 511 , 525 ], for example, gentamicin [ 591 , 592 , 593 , 594 , 595 , 596 ], ibuprofen [ 597 , 598 ], cephalothin [ 593 ], amoxicillin [ 593 ], tobramycin [ 593 ], zoledronate [ 599 ], aspirin [ 600 ], flomoxef sodium [ 601 ], tetracycline [ 602 , 603 ], vancomycin [ 604 , 605 ], streptomycin [ 606 ], etc. Tetracylines have a broad spectrum of antibiotic action and, therefore, are attractive candidates.…”

Section: Antibacterial Calcium Phosphatesmentioning

confidence: 99%

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

2017

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Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials. CaP coating technologies are summarized, with a focus on electrochemical processes. Theories on the formation of transient precursor phases in biomineralization, the dissolution and reprecipitation as bone of CaPs are discussed. A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs. We conclude by foreseeing the future of CaPs.

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Section: Antibacterial Calcium Phosphatesmentioning

confidence: 99%

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

2017

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“…The sharp peaks present at 2θ values of 26.1º, 28.2º, 31.9º, 33.2º, 34.4º, and 40.1º were attributed to the HAP (002), (210), (211), (300), (202) and (212) planes, respectively. 51 The pure HAP phase diffractograms were showed with its JCPDS card number 9-0432. A slight undergoing deviation in positions of planes and the decrease in crystalline nature were observed when the lanthanide trivalent cations were substituted on the Ca 2+ ion's matrix.…”

Section: Phase Analysismentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite/Aloe vera Composite Coated Titanium Plate for Bone Tissue Regeneration

Prabakaran¹,

Rajan²,

Meng³

2020

IJN

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Purpose To develop the surface-treated metal implant with highly encouraged positive properties, including high anti-corrosiveness, bio-activeness and bio-compatibleness for orthopedic applications. Methods In this work, the surface of commercially pure titanium (Ti) metal was treated with bio-compatible polydopamine (PD) by merely immersing the Ti plate in PD solution. The composite of trivalent lanthanide minerals (La 3+ , Ce 3+ and Gd 3+ )-substituted hydroxyapatite (MHAP) with Aloe vera (AV) gel was prepared and coated on the PD-Ti plate by electrophoretic deposition (EPD) method. The choice of trivalent lanthanide ions is based on their bio-compatible nature and bone-seeking properties. The formation of the PD layer, composites, and composite coatings on Ti plate and PD-Ti surface was confirmed by FT-IR, XRD, SEM and HR-TEM observations. In-vitro assessments such as osteoblasts like MG-63 cell viability, alkaline phosphatase activity and mineralization ability of the MHAP/AV composite were tested, and the composite-coated plate was implanted into a rat bone defect model for in-vivo bone regeneration studies. Results The coating ability of the MHAP/AV composite was highly preferred to PD-treated Ti plate than an untreated Ti plate due to the metal absorption ability of PD. This was confirmed by SEM analysis. The in-vitro and in-vivo studies show the better osteogenic ability of MHAP/AV composite at 14 th day and 4 th week of an experimental period, respectively. Conclusion The osteoblast ability of the fabricated device without producing any adverse effect in the rat model recommends that the fabricated device would serve as a better platform on the hard tissue regeneration for load-bearing applications of orthopedics.

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“…All prepared gypsum presents a very similar XRD peak patterns (assigning 020, 021, and 041 planes) with the strongest peaks locating at 11.6 theta degree, which is typical crystallite gypsum (JCPDS: 000210816) and agrees well with our theoretical XRD calculations (Figure S1) using the general scattering equation. 40 In addition, slight shifts of scattering angles were also observed for all crystallite gypsum prepared at different temperatures indicating the variations of crystallite lattice parameters of the prepared gypsum. Although XRF analysis (Table S2) indicates the impurities, the XRD spectra hardly show the crystallite impurities in the matrix of crystallite gypsum.…”

Section: Resultsmentioning

confidence: 88%

Preparation of Catalyst from Phosphorous Rock Using an Improved Wet Process for Transesterification Reaction

Wang

Tang

Yusuf

et al. 2021

Ind. Eng. Chem. Res.

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Gypsum (CaSO4·2H2O) with active catalytic performance was prepared from phosphorous rock through an improved clean wet process. The impact of the preparation conditions was extensively analyzed to identify the statistical significance toward the compositions of the prepared gypsum and catalytic performances during the transesterification reaction. The prepared catalyst predominantly contains CaSO4 (93%) with contaminations of silica (5%), P2O5 (0.25%), Fe2O3 (0.52%), Al2O3 (0.24%), and TiO2 (0.12%). Heavy-metal oxides, that is, Cr2O3, PbO, and CuO, were not detected from the prepared catalyst. The contaminants in gypsum are in the form of complicated composites such as SiO2, (Na2, K2)SiF6, MgF2, AlF3, Ca5(PO4)3F, and Ca3(PO4)2. The significant operational parameters, namely, the crystallization temperature and duration toward the catalytic performance, were identified by ANOVA. The Brönsted acidic sites from the ionic S and O, which might be in the form of S–⃛O or SO as the surface functional groups, attribute to transesterification catalysis. The theoretical simulation suggests that different ionic sulfates might co-exist on the surface of crystallite gypsum. The transport of reagents to the surface of catalytic sites also plays an important role under the investigated experimental conditions. The reusability study indicates an approximate 10% deactivation after the reaction.

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Preparation, characterization and in vitro assessment of ibuprofen loaded calcium phosphate/gypsum bone cements

Cited by 27 publications

References 32 publications

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications

<p>Lanthanides-Substituted Hydroxyapatite/<em>Aloe vera</em> Composite Coated Titanium Plate for Bone Tissue Regeneration</p>

Preparation of Catalyst from Phosphorous Rock Using an Improved Wet Process for Transesterification Reaction

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