2010
DOI: 10.2147/ijn.s12918
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Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles

Abstract: Paclitaxel ( Taxol ® ) is an important anticancer drug in clinical use for treatment of a variety of cancers. Because of its low solubility, it is formulated in high concentration in Cremophor EL ® which induces hypersensitivity reactions. In this study, targeted delivery of paclitaxel-loaded nanoparticles was prepared by a desolvation procedure, crosslinked on the wall material of bovine serum albumin, and subsequently decorated by folic acid. The characteristics of the nanoparticles, such as amount of fo… Show more

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Cited by 80 publications
(21 citation statements)
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“…This pattern of release indicated sustained release of the drug without any burst release. The sustained release of EGCG could be due to the encapsulation of EGCG into albumin nanoparticles and thus Alb-NP-EGCG could have better therapeutic value with prolonged circulation (Zhao et al 2010). Sustained release of other drugs from albumin nanoparticles have been reported in the previous studies also (Yu et al 2014;Syame et al 2018).…”
Section: Encapsulation Efficiency and In Vitro Release Studymentioning
confidence: 82%
“…This pattern of release indicated sustained release of the drug without any burst release. The sustained release of EGCG could be due to the encapsulation of EGCG into albumin nanoparticles and thus Alb-NP-EGCG could have better therapeutic value with prolonged circulation (Zhao et al 2010). Sustained release of other drugs from albumin nanoparticles have been reported in the previous studies also (Yu et al 2014;Syame et al 2018).…”
Section: Encapsulation Efficiency and In Vitro Release Studymentioning
confidence: 82%
“…By contrast with NLC, an enhanced fluorescent intensity was observed in HepG2 cells incubated with B-rLips ( Figure 7A), which exactly confirmed the tumor-targeting property of BSA mainly through the approach of GP60 and SPAR. 32 As illustrated in Figure 7A, the intracellular fluorescent intensity of HepG2 cells treated with FB-rLips was remarkably higher than that in LO2 cells, and the uptake of FB-rLips by HepG2 cells was around 1.41-fold as much as that of B-rLips ( Figure 7B). Nevertheless, there was no remarkable difference between the uptake of FB-rLips and B-rLips by LO2 cells ( Figure 7B).…”
Section: Cell Uptakementioning
confidence: 88%
“…FA-modified BSA (FA-BSA) was combined with NLC by post-insert method to form the lipoproteins-mimic nanocomplex (termed as FB-rLips), which was expected to reconstruct the structure and function of the lipoproteins, to inherit the advantages and make up the shortages of natural lipoproteins, and to further improve tumor-targeting specificity through a combination of FA and BSA. 21,22 The construction of the vehicle was designed as shown in Figure 1. A hydrophobic core of triglycerides and cholesteryl ester was surrounded by a shell of phospholipid monolayer and stabilized by the FA-modified BSA layer.…”
Section: Introductionmentioning
confidence: 99%
“…BSA nanoparticles of efavirenz were prepared by desolvation method. [ 17 ] Five batches of nanoparticles were prepared with varying concentrations of BSA. Briefly known quantity of bovine serum albumin powder was dissolved in 10 ml of distilled water and pH was adjusted to 8 with 0.1 M NaOH solution to get nanoparticles with smaller particle size.…”
Section: Methodsmentioning
confidence: 99%