Preparation, characterization and in vitro anticancer performance of nanoconjugate based on carbon quantum dots and 5-Fluorouracil

Cutrim, Elaine Sá Menezes; Vale, André Álvares Marques; Manzani, Danilo; Barud, Hernane S.; Rodríguez‐Castellón, Enrique; Santos, Ana Paula S A; Alcántara, Ana C. S.

doi:10.1016/j.msec.2020.111781

Cited by 54 publications

(43 citation statements)

References 72 publications

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“…The induced cytotoxicity by the presence of NCQDs in CS‐MMT‐NCQDs hydrogel is in agreement with the results presented by Cutrim et al. [36]. They concluded that the 5‐Fluorouracil‐carbon quantum dots nanoconjugate system caused a higher decline in MCF‐7 viability as compared to free 5‐Fluorouracil.…”

Section: Resultssupporting

confidence: 91%

“…All these findings lead us to conclude the nontoxicity of CS-MMT hydrogel without NCQDs. As shown in Figure 6, the viability of treated cells with CS-MMT-NCQDs is less than that of treated [36]. They concluded that the 5-Fluorouracil-carbon quantum dots nanoconjugate system caused a higher decline in MCF-7 viability as compared to free 5-Fluorouracil.…”

Section: In Vitro Cytotoxicity Assaymentioning

confidence: 94%

“…Based on their results, the fabricated nanocarrier retained the release of 5‐fluorouracil in the normal physiological condition (pH 7.4), while releasing almost the entire drug in the tumor microenvironment (pH 5.4) [35]. The nanomaterials of CQDs were examined by Cutrim and his colleagues during the discharge of 5‐FU [36]. Antitumor 5‐FU was self‐assembled onto carbon quantum dots in this work to provide a unique medication delivery method.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Rahmani

Pourmadadi

Ghorbanian

et al. 2022

Engineering in Life Sciences

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Despite its widespread usage as a chemotherapy drug in cancer treatment, doxorubicin (DOX) has limitations such as short in vivo circulation time, low solubility, and poor permeability. In this regard, a pH-responsive chitosan (CS)-montmorillonite (MMT)-nitrogen-doped carbon quantum dots (NCQDs) nanocomposite was first developed, loaded with DOX, and then incorporated into a double emulsion to further develop the sustained release. The incorporated NCQDs into the CS-MMT hydrogel exhibited enhanced loading and entrapment efficiencies. The presence of NCQDs nanoparticles in the CS-MMT hydrogel also resulted in an extended pH-responsive release of DOX over a period of 96 h compared to that of CS-MMT-DOX nanocarriers at pH 5.4. Based on the Korsmeyer-Peppas model, there was a controlled DOX release at pH 5.4, while no diffusion was observed at pH 7.4, indicating fewer side effects. MTT assay showed that the cytotoxicity of DOX-loaded CS-MMT-NCQDs hydrogel nanocomposite was significantly higher than those of free DOX (p < 0.001) and CS-MMT-NCQDs (p < 0.001) on MCF-7 cells. Flow cytometry results demonstrated that a higher

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Section: Resultssupporting

confidence: 91%

Section: In Vitro Cytotoxicity Assaymentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Rahmani

Pourmadadi

Ghorbanian

et al. 2022

Engineering in Life Sciences

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“… 1 From the previous reasons, cancer can be listed as the second main cause of worldwide deaths. 2 Based on the recent expectations, the world will face grave challenges of an interminable increase of cancer deaths by 75%, especially from colorectal cancer (CRC). 3 CRC is extensively distributed in the world, especially in developing and poor countries.…”

Section: Introductionmentioning

confidence: 99%

“… 5 , 6 Additionally, great efforts have been made to enhance the performance of common chemotherapeutic drugs such as 5-fluorouracil (5-Fu), considering the bioavailability, efficiency, solubility, and specificity of the drug toward tumors. 2 , 4 , 7 …”

Section: Introductionmentioning

confidence: 99%

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

et al. 2022

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Herein, natural zeolite (clinoptilolite) was functionalized by Na + ions (G.Na + /Clino) utilizing a green tea extract prepared by a green production method as a potential carrier for the 5-fluorouracil (5-Fu) drug with enhanced physicochemical behaviors. The G.Na + /Clino-modified product showed enhanced surface area (312 m 2 /g) and ion-exchange capacity (387 mequiv/100 g). The loading studies reflect high and controlled loading properties of G.Na + /Clino with an actual loading capacity of 291 and 462 mg/g, respectively. The loading reactions of 5-Fu into G.Na + /Clino were of pseudo-second-order kinetics and exhibited Langmuir isotherm properties. This suggested a monolayer and homogeneous loading process by chemical complexation and ion-exchange mechanisms with a Gaussian energy value of 10.47 kJ/mol. Additionally, these reactions were of endothermic and spontaneous nature based on the determined thermodynamic parameters. The release studies demonstrated the 5-Fu release profile for about 150 h at pH 1.2 and for 80 h at pH 7.4. The release reactions had non-Fickian transport properties and were controlled by both erosion and diffusion mechanisms, considering the release kinetic findings and the values of the diffusion exponent (0.42 at pH 1.2 and 0.37 at pH 7.4). The composite showed remarkable biocompatibility based on the measured cell viability and a cytotoxic effect on normal colorectal cells (CCD-18Co). Additionally, the application of G.Na + /Clino as an inorganic carrier for the 5-Fu drug prompted the cytotoxic effect of the drug on colon cancer cell treatment (HCT-116).

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Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects

Pechnikova,

Domvri,

Porpodis

et al. 2024

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Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress in utilizing CQDs for drug delivery, bioimaging, biosensing, and cancer therapy. With their unique optical properties, such as tunable fluorescence, high quantum yield, and photostability, CQDs enable precise bioimaging and sensitive biosensing. Their small size, biocompatibility, and ease of surface functionalization allow for the development of targeted drug delivery systems, enhancing therapeutic precision and minimizing side effects. In cancer therapy, CQDs have shown potential in photodynamic and photothermal treatments by generating reactive oxygen species under light exposure, selectively targeting cancer cells while sparing healthy tissues. Furthermore, CQDs’ ability to penetrate biological barriers including the blood–brain barrier opens new possibilities for delivering therapeutic agents to hard‐to‐reach areas, such as tumors or diseased tissues. However, challenges such as optimizing synthesis, ensuring long‐term stability, and addressing safety concerns in biological environments remain critical hurdles. This review discusses current efforts to overcome these barriers and improve CQD performance in clinical settings, including scalable production methods and enhanced biocompatibility. As research progresses, CQDs are expected to play an important role in improving healthcare by offering more targeted treatment options and contributing to advancements in personalized medicine.

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Preparation, characterization and in vitro anticancer performance of nanoconjugate based on carbon quantum dots and 5-Fluorouracil

Cited by 54 publications

References 72 publications

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects

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Preparation, characterization and in vitro anticancer performance of nanoconjugate based on carbon quantum dots and 5-Fluorouracil

Cited by 54 publications

References 72 publications

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy

Insight into the Loading Properties of Na+ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity

Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects

Contact Info

Product

Resources

About

Insight into the Loading Properties of Na⁺ Green-Functionalized Clinoptilolite as a Potential Carrier for the 5-Fluorouracil Drug, its Release Kinetics, and Cytotoxicity