Preparation, characterization and in vitro release study of β-cyclodextrin/chitosan nanoparticles loaded Cinnamomum zeylanicum essential oil

Matshetshe, Kabo; Parani, Sundararajan; Manki, Sarah M.; Oluwafemi, Oluwatobi S.

doi:10.1016/j.ijbiomac.2018.06.125

Cited by 120 publications

(53 citation statements)

References 37 publications

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“…Ye et al [26] synthesized blank NPs with a size of 238.5 to 391.2 nm and when these NPs were loaded with paclitaxel/dimethyl-β-CD, larger particles with diameters ranging from 440.2 to 521.4 nm were formed. In the present study also it was observed that the particle size increased with drug loading as reported in literature [28,[41][42][43][44] .…”

Section: Resultssupporting

confidence: 87%

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Büyük¹,

Arayıcı²,

Derman³

et al. 2020

ijps

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Buyuk et al.: Amiodarone-loaded Chitosan NanoparticlesThis work is based on a natural polymer chitosan used in a nanoparticulate drug delivery system for the controlled release of amiodarone along with β-cyclodextrin. Amiodarone-loaded chitosan nanoparticles were prepared using the ionic gelation method aided by sonication. Amiodarone loading on chitosan nanoparticles was done under optimum conditions. For particle characterization; zeta-sizer, UV/Vis, Fourier-transform infrared spectroscopy, X-ray powder diffraction, differential scanning calorimeter and scanning electron microscope techniques were used. In vitro drug release studies of amiodaroneloaded chitosan nanoparticles were performed using the dialysis diffusion technique. Drug loading and release values were determined using UV/Vis spectroscopy. Amiodarone encapsulated in nanoparticles was completely released at the end of 14 days. About 38 % was released at the end of day 1, 44% released at the end of day 3, 50 % released at the end of day 5 followed slow release. Amiodarone-loaded chitosan nanoparticles could serve as a model for controlled delivery of many antiarrhythmic drugs.

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Section: Resultssupporting

confidence: 87%

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Büyük¹,

Arayıcı²,

Derman³

et al. 2020

ijps

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“…In pharmaceutical nanotechnology, chitosan is not only used as a matrix-forming polymer [ 182 ] for the encapsulation of bioactive substances but also as a surface coating material. Drug delivery nanosystems decorated with chitosan are commonly polymeric nanoparticles mainlypoly(lactic- co -glycolic acid) (PLGA), poly(lactic acid) (PLA), poly(caprolactone) (PCL) or natural polymers, alginates, oligosaccharides (e.g., CDs [ 183 ]) and lipid-based nanoparticles such as liposomes [ 184 ], solid lipid nanoparticles (SLNs [ 185 ]), nanostructured lipid carriers (NLCs [ 186 ]) and metal nanoparticles.…”

Section: Chitosan-coated and Modified Chitosan Nanosystems Encapsumentioning

confidence: 99%

“…Moreover, electrostatic deposition could be applied for the formation of CCNs either in already formed negatively charged nanoparticles or during the formation of the nanoparticles ( Figure 7 ). Both approaches have been used to prepare coated polymeric nanoparticles, lipid nanoparticles and metal-based nanoparticles as well [ 183 , 186 , 188 , 189 , 206 , 207 , 208 ]. Especially, natural products such as curcumin [ 209 ] and resveratrol [ 192 ] were successfully encapsulated in chitosan-coated nanoformulations where the coating process was accomplished using pre-formed nanoemulsions and lipid microparticles, respectively.…”

Section: Chitosan-coated and Modified Chitosan Nanosystems Encapsumentioning

confidence: 99%

“…Matshetshe et al [ 183 ], thoroughly studied the encapsulation of the Cinnamomum zeylanicum EO in the system β-CD/chitosan nanosystem presenting that the encapsulation of the EO in the oligosaccharide first differentiated significantly the system. The size of nanoparticles lacking the β-CD ranged from 123.3 to 326.4 nm, their zeta potential was found to be between 24 and 30.5 mV while the encapsulation efficiency (EE) 10–20%, depending on the conditions under which the nanopatricles’ preparation was carried out.…”

Section: Chitosan-coated and Modified Chitosan Nanosystems Encapsumentioning

confidence: 99%

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Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

et al. 2020

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Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers’ formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.

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“…Initial drawbacks such as low encapsulation efficiency of Ch-NPs can be improved by employing inclusion complexes such as βcyclodextrin (▶ Fig. 4) [108]. Other commonly used systems for the encapsulation of volatiles are MSNPs (Mesoporous silica nanoparticles) and MNPs (metal nanoparticles).…”

Section: Nanoencapsulation Systems For Carrying Plant Volatile Organimentioning

confidence: 99%

Nanoencapsulation of Plant Volatile Organic Compounds to Improve Their Biological Activities

Mun

Townley

2020

Planta Med

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Plant volatile organic compounds (volatiles) are secondary plant metabolites that play crucial roles in the reproduction, defence, and interactions with other vegetation. They have been shown to exhibit a broad range of biological properties and have been investigated for antimicrobial and anticancer activities. In addition, they are thought be more environmentally friendly than many other synthetic chemicals 1. Despite these facts, their applications in the medical, food, and agricultural fields are considerably restricted due to their volatilities, instabilities, and aqueous insolubilities. Nanoparticle encapsulation of plant volatile organic compounds is regarded as one of the best strategies that could lead to the enhancement of the bioavailability and biological activity of the volatile compounds by overcoming their physical limitations and promoting their controlled release and cellular absorption. In this review, we will discuss the biosynthesis and analysis of plant volatile organic compounds, their biological activities, and limitations. Furthermore, different types of nanoparticle platforms used to encapsulate the volatiles and the biological efficacies of nanoencapsulated volatile organic compounds will be covered.

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Preparation, characterization and in vitro release study of β-cyclodextrin/chitosan nanoparticles loaded Cinnamomum zeylanicum essential oil

Cited by 120 publications

References 37 publications

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Synthesis of Chitosan Nanoparticles for Controlled Release of Amiodarone

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Nanoencapsulation of Plant Volatile Organic Compounds to Improve Their Biological Activities

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