Preparation, characterization, and in vitro bioactivity of magnetic co‐polymer [N, N‐dimethylaminopropylacrylamide‐co‐1‐allylimidazole] as a new nanocarrier for delivery of cefotaxime

Abstract

In this research, new magnetic nanoparticles (MNPs) conjugated radical co‐polymerization with N, N‐dimethylaminopropylacrylamide (N, N‐DMAPAAm) as a thermosensitive monomer and 1‐allylimidazole (AI) as a cross‐linker agent was prepared as a magnetic nanocomposite (MNC). The synthesized MNC were characterized by Fourier transform infrared spectroscopy, Elemental analysis (CHN), Field emission scanning electron microscopy, Vibrating Sample Magnetometer, and Thermo Gravimetric Analysis. Cefotaxime was selected as a model drug and was loaded into the synthesized polymer. The main factors of adsorption process such as pH, contact time, temperature, and eluent were evaluated and optimized. The mechanism of cefotaxime adsorption is explained by Langmuir isotherm. Also, in vitro cefotaxime delivery in the simulated gastric and intestinal fluids was investigated. The drug release profile revealed that about 30.35% of the adsorbed cefotaxime was released in the first 30 min. at pH =1.2 (simulated gastric fluid) and 62.65% was released during 15 h at pH =7.4 (simulated intestinal fluid).