Preparation, characterization and lysozyme immobilization studies on siliceous mesocellular foams: Effect of precursor chemistry on pore size, wall thickness and interpore spacing

Synthesis and functionalisation of spherical meso-, hybrid meso/macro- and macro-porous cellular silica foam materials with regulated pore sizes for CO2 capture

“…Schmidt-Winkel et al 41 found that the cell cavity or pore size has a linear relationship with the cubic root of the TMB/P123 mass ratio, which is in contrast to the direct linear relationship observed in a later investigation by Sridhar et al 44 However, no such linear relationships were obtained across the whole wider range of TMB/P123 and aging temperatures examined in our investigation while our synthesised cellular foams were found to have signicantly larger pore diameters and much lower surface areas compared to those obtained in previous investigations. 41,44,45 Regarding the effect of precursor chemistry and preparation conditions on SCF wall thickness, van Grieken et al and Schmidt-Winkel et al both found that enhanced silica condensation is directly responsible for increased wall thickness, 41,45 which contradicts the ndings of Sridhar et al 44 that increased wall thickness is not a result of enhanced silica condensation but shrunken pore size and a transition of pore geometry from being spherical to cylindrical. However, the ndings revealed in Fig.…”

<p>Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen</p>

“…22 The interconnected nature of the new mesostructured silicas are favorable for a wide range of applications and are promising candidates to be used in the field of drug delivery. 23 How to precisely control the structures of silica nanoparticles is crucial to the practical applications and often achieved by a top-down synthetic approach including chemical vapor deposition and lithography/etching processes which require harsh conditions (such as extreme pH, temperature and pressure). 24 Inspired by the biominerals existing widely in nature with complex nanostructures or nanopatterns, such as diatoms, radiolarians and sponges, novel biological silica formation synthetic routes called biosilicification have been established to fabricate inorganic materials, which is a nontrivial bottom-up synthetic procedure.…”

“…The formation of biominerals is genetically controlled by specialized biomacromolecules such as polypeptides, polysaccharides, amino acid derivatives and proteins that catalyze the polymerization and hydrolysis through a sol-gel process. [23][24][25][26][27] Recently, biomimetic synthesis of silica fabrication has attracted increasing attention due to the cost-effective manufacture of nanopatterns and the precise control over shape. A great number of amine-containing biomacromolecules are easily available and in turn facilitate the versatility of silica structure carriers, thus resulting in multiple morphogenesis of biomimetic synthesized silicas including nanospheres, nanoflakes, nanoribbons, nanosheets, twisted nanorods, helical nanofibers, curved nanofilms and large aggregates.…”

Gelatin/carboxymethyl cellulose mucoadhesive films with lysozyme: Development and characterization

“…Over the last few decades, there were many examples of the development of lysozyme-loaded forms with used polymeric matrix of natural or synthetic origin, such as siliceous mesocellular foams (Sridhar et al, 2014), ethylene vinyl alcohol copolymers (Muriel-Galet, Talbert, Hernandez-Munoz, Gavara & Goddard, 2013), electrospun chitosan nanofiber (Park, Kim, Park, Jang, Min & Kim, 2013), glycerol diglycidyl ether cross-linked oxidized starch (Zhao et al, 2015), carboxymethyl chitosan-poly(amidoamine) dendrimer (Zhang, Zhao, Wen, Zhu, Yang & Yao, 2013), cellulose and polyacrylamide (Datta, Armiger & Ollis, 1973), calcium carbonate/carboxymethyl cellulose (Lu, Zhang, Ma, Song & Gu, 2012), keratin sponge (Kurimoto, Tanabe, Tachibana & Yamauchi, 2003), chitosan (Bucatariu, 2013), silica nanotubes and nanotubes (Ding, Shao, Liu, Xiao & Chen, 2005; Xiao, Tao, Zou & Chen, 2008), zeolite (Chang, Huang, Lin, Chiu & Tsai, 2006), polystyrene (Wu & Daeschel, 2007), and others. We also consider this direction as promising and thus aimed the current study to develop and characterize mucoadhesive films with incorporated lysozyme based on gelatin/sodium carboxymethyl cellulose as perspective antimicrobial preparation.…”