Preparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriers

Shi, Feng; Zhao, Yingying; Firempong, Caleb Kesse; Xu, Ximing

doi:10.3109/13880209.2016.1155630

Cited by 62 publications

(36 citation statements)

References 46 publications

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“…These challenges could be overcomed by new "lipid-based nano-encapsulation approaches" for targeted delivery of these functional compounds (Esfanjani, Assadpour, & Jafari, 2018). Innovative technologies such as nanocrystals, lipid-based nanoparticles including liposomes, phytosomes, micelles, solid lipid nanoparticles, microemulsions, and nanoemulsions, and solubility enhancing agents such as cyclodextrin have been reported for improvement of beneficial effects of celery's compounds (Dang et al, 2014;Ding, Zhang, et al, 2014;Huang et al, 2016;Khan, Saraf, & Saraf, 2016;Kim, Cho, & Park, 2016;Luo et al, 2019;Mahalapbutr et al, 2019;Shi, Zhao, Firempong, & Xu, 2016;Shin et al, 2018;Telange et al, 2017;Wu, Li, Yue, Zhang, & Yunusi, 2018;Wu et al, 2017;Zhai et al, 2013;Zhang, Huang, Liu, Gao, & Qian, 2013;Zhang, Cui, Wei, & Lv, 2017;Zhao, Wang, & Li, 2016). The effects of celery on metabolic syndrome are shown in Figure 2.…”

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confidence: 99%

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Hedayati

Naeini

Mohammadinejad

et al. 2019

Phytotherapy Research

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The metabolic syndrome (MetS) is a cluster of multiple conditions that includes hypertension, dyslipidemia, abdominal obesity, and hyperglycemia disorders. Most studies revealed that the MetS is accompanied with an increased risk for cardiovascular disease, Type 2 diabetes mellitus, and insulin resistance. It can be said that, in treating or preventing the MetS and its components, lifestyle adjustment and weight loss have a vital role. According to various studies, among natural compounds, celery (Apium graveolens) is one of the most important sources of phytochemicals such as phenolic acids, flavones, flavonols, and antioxidants such as vitamin C, beta‐carotene (Provitamin A), and manganese. These antioxidants have a role in decreasing the oxidative damage. The phytochemicals in celery decrease the activity of proinflammatory cytokines and prevent inflammation. Also, flavonoids in celery suppress cardiovascular inflammation. Oxidative stress and inflammation in the blood stream are the main risk factors in increasing cardiovascular disease, especially atherosclerosis. Celery phthalides leads to expanding of smooth muscle in the blood vessels and lower blood pressure. As a result, the most active ingredients in celery (A. graveolens (have shown hypolipidemic, antidiabetic, and hypotensive properties. In this review, we summarized the mechanisms underlying the protective effects of celery components on insulin action, glucose, lipid metabolism, and blood pressure.

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mentioning

confidence: 99%

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Hedayati

Naeini

Mohammadinejad

et al. 2019

Phytotherapy Research

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“…The solubility of the monoterpenes is an important factor in the evaluation of their anti-ulcer effects. Generally, these compounds exhibit inadequate solubility, usually resulting in poor bioavailability and further limiting their application [54]. Most of the monoterpenes described in Tables 1 and 2 were solubilized in Tween 80, varying in their proportion of dilution (0.1-10%).…”

Section: Acetic Acidmentioning

confidence: 99%

“…Nanoparticles as an effective drug delivery system have become known for their advantage at solving problems related to the solubility and bioavailability of monoterpenes. For example, previous research of linalool-loaded nanostructured lipid carriers [54] or the same linalool incorporated into inclusion complex containing β-cyclodextrin revealed significantly improved anti-ulcer effects [53].…”

Section: Acetic Acidmentioning

confidence: 99%

Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

et al. 2020

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Peptic ulcer disease (PUD) is a multifactorial and complex disease caused by an imbalance of protective and aggressive factors (endogenous and exogenous). Despite advances in recent years, it is still responsible for substantial mortality and triggering clinical problems. Over the last decades, the understanding of PUD has changed a lot with the discovery of Helicobacter pylori infection. However, this disease continues to be a challenge due to side-effects, incidence of relapse from use of various anti-ulcer medicines, and the rapid appearance of antimicrobial resistance with current H. pylori therapies. Consequently, there is the need to identify more effective and safe anti-ulcer agents. The search for new therapies with natural products is a viable alternative and has been encouraged. The literature reports the importance of monoterpenes based on the extensive pharmacological action of this class, including wound healing and anti-ulcerogenic agents. In the present study, 20 monoterpenes with anti-ulcerogenic properties were evaluated by assessing recent in vitro and in vivo studies. Here, we review the anti-ulcer effects of monoterpenes against ulcerogenic factors such as ethanol, nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori, highlighting challenges in the field.Biomolecules 2020, 10, 265 2 of 18 PUD results from an imbalance in mucosal defensive factors, such as mucus secretion, bicarbonate efflux, endogenous antioxidant, cell regeneration, continuous synthesis and release of prostaglandin E 2 (PGE 2 ), nitric oxide (NO), and sulfhydryl compounds (SH); and aggressive agents such as smoking, alcohol consumption, dietary factors, stress, prolonged and excessive intake of nonsteroidal anti-inflammatory drugs (NSAIDs), and Helicobacter pylori (H. pylori) infection, among others [6][7][8][9]. For a long time, it was believed that the main factor implicated in the development and progression of peptic ulceration was an hypersecretory acidic environment and together with dietary factors and/or stress was thought to cause most of PUD. But the discovery of H. pylori infection and the widespread use of NSAIDs in the second half of the 20 th century changed this perception. In recent years, peptic ulcer has been found to have multiple causes-H. pylori infection, NSAIDs, smoking, alcohol consumption, stress, lifestyle, and genetic predispositions are determined as major risk factors for the development of PUD [2]. PathophysiologyUnder normal conditions, gastric and duodenal mucosa integrity is maintained by the mucus-bicarbonate barrier, the neutral pH, and continuous epithelial cell renewal [10,11]. PGE 2 stimulates cell proliferation, mucus, and bicarbonate production, promoting a crucial function in mucosa preservation. Another vital factor in gastric homeostasis is adequate blood flow. The NO and PGs are responsible for the maintenance of proper perfusion to the gastric mucosa, assuring the delivery of oxygen and nutrients, as well as removing toxic metabolites, preventing damages to the ti...

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“…35 A p-value < 0.05 was considered significant. [36][37][38][39][40][41][42] Figure 3. Representative HPLC chromatograms after deproteinization of drug-free rat plasma peaks: fenofibric acid (1) (5.9 min) and (2) (7.7 min).…”

Section: Pharmacokinetic and Statistical Analysesmentioning

confidence: 99%

Synthesis and Evaluation of Fenofibric Acid Ester Derivatives: Studies of Different Formulation with Their Bioavailability and Absorption Conditions

Lv¹,

Wang²,

Xiao³

et al. 2020

J. Braz. Chem. Soc.

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A series of fenofibric acid ester pro-drugs (JF-1-7) were synthesized. The pharmacokinetic properties of these pro-drugs were examined after oral administration to rats at a dose of 20 mg kg-1 to evaluate the relative bioavailability in rats. The bioavailability of the ester compounds, JF-1, 2, 3, 4, 5, 6, and 7, was significantly higher than that of fenofibrate. In particular, JF-2 proved to be most promising. The oral administration (20 mg kg-1) of JF-2 showed a relative bioavailability of approximately 272.8% compared to fenofibrate.

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Preparation, characterization and pharmacokinetic studies of linalool-loaded nanostructured lipid carriers

Cited by 62 publications

References 46 publications

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Beneficial effects of celery (Apium graveolens) on metabolic syndrome: A review of the existing evidences

Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases

Synthesis and Evaluation of Fenofibric Acid Ester Derivatives: Studies of Different Formulation with Their Bioavailability and Absorption Conditions

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