Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride

Zha, Liqiong; Wang, Beilei; Qian, Jiajia; Fletcher, R. Brock; Zhang, Caiyun; Dong, Qin; Chen, Weidong; Hong, Lufeng

doi:10.1111/jphp.13223

Cited by 19 publications

(7 citation statements)

References 45 publications

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“…These results demonstrated that Fe 3 O 4 /DOX@CNSs with a sustained release property could significantly improve the bioavailability of DOX. 66 …”

Section: Resultsmentioning

confidence: 99%

A Multifunctional, Highly Biocompatible, and Double-Triggering Caramelized Nanotheranostic System Loaded with Fe3O4 and DOX for Combined Chemo-Photothermal Therapy and Real-Time Magnetic Resonance Imaging Monitoring of Triple Negative Breast Cancer

Wang¹,

Li²,

Wang³

et al. 2023

IJN

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Purpose Owing to lack of specific molecular targets, the current clinical therapeutic strategy for triple negative breast cancer (TNBC) is still limited. In recent years, some nanosystems for malignancy treatment have received considerable attention. In this study, we prepared caramelized nanospheres (CNSs) loaded with doxorubicin (DOX) and Fe 3 O 4 to achieve the synergistic effect of combined therapy and real-time magnetic resonance imaging (MRI) monitoring, so as to improve the diagnosis and therapeutic effect of TNBC. Methods CNSs with biocompatibility and unique optical properties were prepared by hydrothermal method, DOX and Fe 3 O 4 were loaded on it to obtain Fe 3 O 4 /DOX@CNSs nanosystem. Characteristics including morphology, hydrodynamic size, zeta potentials and magnetic properties of Fe 3 O 4 /DOX@CNSs were evaluated. The DOX release was evaluated by different pH/near-infrared (NIR) light energy. Biosafety, pharmacokinetics, MRI and therapeutic treatment of Fe 3 O 4 @CNSs, DOX and Fe 3 O 4 /DOX@CNSs were examined in vitro or in vivo. Results Fe 3 O 4 /DOX@CNSs has an average particle size of 160 nm and a zeta potential of 27.5mV, it demonstrated that Fe 3 O 4 /DOX@CNSs is a stable and homogeneous dispersed system. The hemolysis experiment of Fe 3 O 4 /DOX@CNSs proved that it can be used in vivo. Fe 3 O 4 /DOX@CNSs displayed high photothermal conversion efficiency, extensive pH/heat-induced DOX release. 70.3% DOX release is observed under the 808 nm laser in the pH = 5 PBS solution, obviously higher than pH = 5 (50.9%) and pH = 7.4 (less than 10%). Pharmacokinetic experiments indicated the t1/2β, and AUC 0–t of Fe 3 O 4 /DOX@CNSs were 1.96 and 1.31 -fold higher than those of DOX solution, respectively. Additionally, Fe 3 O 4 /DOX@CNSs with NIR had the greatest tumor suppression in vitro and in vivo. Moreover, this nanosystem demonstrated distinct contrast enhancement on T2 MRI to achieve real-time imaging monitoring during treatment. Conclusion Fe 3 O 4 /DOX@CNSs is a highly biocompatible, double-triggering and improved DOX bioavailability nanosystem that combines chemo-PTT and real-time MRI monitoring to achieve integration of diagnosis and treatment of TNBC.

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“…These results demonstrated that Fe 3 O 4 /DOX@CNSs with a sustained release property could significantly improve the bioavailability of DOX. 66 …”

Section: Resultsmentioning

confidence: 99%

A Multifunctional, Highly Biocompatible, and Double-Triggering Caramelized Nanotheranostic System Loaded with Fe3O4 and DOX for Combined Chemo-Photothermal Therapy and Real-Time Magnetic Resonance Imaging Monitoring of Triple Negative Breast Cancer

Wang¹,

Li²,

Wang³

et al. 2023

IJN

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“…The statistical data showed that the number of patients with thrombocytopenia (7 cases), elevated myocardial enzyme (5 cases), alopecia (13 cases), liver failure (7 cases), gastrointestinal reactions (12 cases), and peripheral neuritis (4 cases) in the observation group was significantly reduced compared with the control group (14,11,25,11,16, 24 cases, respectively). The total was 48 cases in the observation group and 101 cases in the control group.…”

Section: The Occurrence Of Side Effects In Patients From the Two Grou...mentioning

confidence: 95%

“…What's more, it can also effectively understand the changes in bone mineral density of patients when MM is diagnosed by MRI. If the patient has soft tissue masses, it often shows a low signal, displaying "salt and pepper" signs (14,15). In this study, patients from the control group underwent the CT examinations, while the observation group received the MRI combined with the CT examination.…”

Section: Comparison Of the Survival Rate And Apoptosis Rate Of Myelom...mentioning

confidence: 99%

Magnetic Resonance Imaging combined with Computed Tomography in the Diagnosis of Multiple Myeloma and the Killing Effect of Doxorubicin Nano-drug Delivery System on Myeloma Cells

Liao¹,

Yu²,

Rui³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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It was to adopt magnetic resonance imaging (MRI) combined with computed tomography (CT) to diagnose multiple myeloma (MM) and evaluate the therapeutic effect of the doxorubicin nano-drug delivery system on MM, providing a more effective method for the treatment of MM. For this aim, eighty-eight patients with MM admitted to our Hospital from June 2019 to July 2020.7 were selected as study subjects and divided into a control group (treated with doxorubicin) and an observation group (treated with doxorubicin-loaded nanoparticles) according to the random number table, 44 cases for each group. MRI and CT were used to examine the two groups of patients to assess the clinical efficacy and side effects of the two treatments and to compare the myeloma cell survival rate and apoptosis rate. Results showed that the diameter of nanoparticles was about 50 nm, the particle size was uniform, the distribution was dense, and the stability was good; the lesion was well-circumscribed on CT scan, and a soft tissue mass could be detected on MRI. The number of patients with effective treatment in the observation group was significantly higher than that in the control group (42 cases vs 34 cases) (P< 0.05); the number of patients with small plate reduction, increased myocardial enzymes, alopecia, liver failure, gastrointestinal reactions, peripheral neuritis, and other adverse reactions in the observation group was significantly lower than that in the control group (total number of patients 48 vs 101) (P< 0.05); the survival rate of myeloma cells in the observation group was obviously inferior to that in the control group (61.3 % vs 88.31 %) (P< 0.05). Conclusion: MRI combined with CT examination can be better used for the diagnosis of the disease, and the study shows that doxorubicin nano-drug delivery preparation is safer and more effective in the treatment of MM disease, which is worthy of clinical promotion.

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“…A recent study demonstrated the use of hydroxyapatite/zein nanocomposite as a carrier for doxorubicin hydrochloride [ 90 ]. The results indicated good colloidal stability.…”

Section: Applications In Drug Deliverymentioning

confidence: 99%

Surface-Tailored Zein Nanoparticles: Strategies and Applications

et al. 2021

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Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuable contender for several in vitro and in vivo applications. The unique structure and possibility of surface covering with distinct coating shells or even surface chemical modifications have enabled zein utilization in active targeted and site-specific drug delivery. This work summarizes up-to-date studies on zein formulation technology based on its structural features. Additionally, the multiple applications of zein, including drug delivery, cellular imaging, and tissue engineering, are discussed with a focus on zein-based active targeted delivery systems and antigenic response to its potential in vivo applicability.

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Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride

Cited by 19 publications

References 45 publications

A Multifunctional, Highly Biocompatible, and Double-Triggering Caramelized Nanotheranostic System Loaded with Fe3O4 and DOX for Combined Chemo-Photothermal Therapy and Real-Time Magnetic Resonance Imaging Monitoring of Triple Negative Breast Cancer

A Multifunctional, Highly Biocompatible, and Double-Triggering Caramelized Nanotheranostic System Loaded with Fe3O4 and DOX for Combined Chemo-Photothermal Therapy and Real-Time Magnetic Resonance Imaging Monitoring of Triple Negative Breast Cancer

Magnetic Resonance Imaging combined with Computed Tomography in the Diagnosis of Multiple Myeloma and the Killing Effect of Doxorubicin Nano-drug Delivery System on Myeloma Cells

Surface-Tailored Zein Nanoparticles: Strategies and Applications

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