Preparation, characterization of some transition metal complexes of hydrazone derivatives and their antibacterial and antioxidant activities

Aly, S. A.; Fathalla, Shaimaa K.

doi:10.1016/j.arabjc.2019.12.003

Cited by 73 publications

(62 citation statements)

References 75 publications

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“…The analytical results of the complexes are consistent with the proposed molecular formula and confirm the formation of M:L (1:1) of Pd (II) and Cd (II) complexes, whereas Cu(I) complex produces M:2 L when reacts with hydrazone ligand. [ 33 ] The values of molar conductance of B 1 , B 2 and B 3 in 10 −3 molar DMF solution fall in the range of 12–20 Ω −1 cm 2 mol −1 , which revealed that non‐electrolyte nature. [ 41 ]…”

Section: Resultsmentioning

confidence: 99%

“…The TGA curves appearances one step of decomposition within heat from 103–799 and 150–510°C with mass loss of (Calc/Found%:69.22/68.47 and 68.95/69.22) correlated with DTG curves at 243, 324; 334, 485; 414°C and 635°C as departure of PdO (Calc./Found%: 28.60/28.28 and 28.60/28.28) as final remainder. [ 33,48,49 ] While the DSC curve of the complex (B 1 ) shows an exothermic peak at 238°C, 250°C, and 372°C changed to 250°C and 370°C after irradiation.…”

Section: Resultsmentioning

confidence: 99%

“…In a round flask, (0.01 mole, 1.65 g) of anilinohydrazide and (0.01 mole, 1.12 g) of 2‐thiophene carbaldehyde were mixed in 20 mL of absolute ethanol The resulting mixture was blended at room temperature for about 6 h. The resulting precipitate was filtered off, washed several times with ethanol and diethyl ether and dried in vacuum. [ 33 ]…”

Section: Methodsmentioning

confidence: 99%

“…Current research work is a continuation of our ongoing interest in ligands and metal complexes by using gamma irradiation, [ 31,32 ] where the effect of gamma ray on the ligand ((Z)‐2‐(phenylamino)‐N′‐(thiophen‐2‐ylmethylene) acetohydrazide)(H 2 L B ) and its complexes with Pd (II), Cd (II), and Cu(I) metal ion [ 33 ] have been studied.…”

Section: Introductionmentioning

confidence: 99%

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Quantum chemical studies and effect of gamma irradiation on the spectral, thermal, X‐ray diffraction and DNA interaction with Pd (II), Cu(I), and Cd (II) of hydrazone derivatives

Aly

Elganzory

Mahross

et al. 2021

Applied Organom Chemis

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A new series of Pd (II), Cd (II), and Cu(I) complexes with ((Z)‐2‐(phenylamino)‐N′‐(thiophen‐2‐ylmethylene)acetohydrazide)(H2LB) has been prepared. FT‐IR, 1H‐NMR, electronic spectra, Powder X‐ray, thermal behavior, theoretical methods and DNA interaction of ligand and of Pd (II) and Cu(I) complexes before and after γ‐irradiation are studied. The 1H NMR spectrum of the ligand after γ‐irradiation shows the signals appear at the same position or slightly shift, but the intensity of the bands after γ‐irradiation is higher than before irradiated. X‐ray diffraction (XRD) studies exhibited the samples in nanorange, the crystallite size is 1.94, 4.81 nm for both unirradiated (B1 and B3) and 2.93, 4.72 nm for irradiated (A1 and A3). The thermal stability of the complexes after γ‐irradiation increase than before γ‐irradiation. The possible structures of the metal complexes have been computed using the molecular mechanic calculations UFF using quantum chemical software by Gaussian 09 W program. The calculations are performed with DFT/B3LYP/LANL2DZ to obtain the optimized molecular geometry. Some important quantum chemical descriptors of the metal complexes were calculated such as HOMO, LUMO, and energy gap. Metal complexes before and after irradiation in the absence and presence of increasing amounts of CT‐DNA exhibit that the absorption intensities decrease with increasing the concentration of DNA.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantum chemical studies and effect of gamma irradiation on the spectral, thermal, X‐ray diffraction and DNA interaction with Pd (II), Cu(I), and Cd (II) of hydrazone derivatives

Aly

Elganzory

Mahross

et al. 2021

Applied Organom Chemis

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“…DPPH has generally been used to estimate the free radical scavenging ability of different antioxidants. The radical scavenging activity of metal complexes and ligand-tested samples were determined with the (2,2-diphenyl-1-picrylhydrazyl) DPPH technique [ 11 ]. The entire tested samples were prepared in various combinations (50, 100 and 150 µg/mL) of metal complexes, and free ligand-blended with 2-mL MeOH (0.1 mM) solution of the DPPH radical and kept at room temperature for 30 min in a dark place.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Spectral Characterization and Biological Activities of Co(II) and Ni(II) Mixed Ligand Complexes

Manimaran¹,

Balasubramaniyan²,

Azam

et al. 2021

Molecules

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2,4-Dinitrophynylhydrazine and two thiocyanate ions in a (M:L1:L2) 1:2:2 molar ratio was synthesized in the complexes of Co(II) and Ni(II). The prepared compounds were identified through a C.H.N.S. analysis, conductivity measurements, powder X-ray diffraction (PXRD), the infrared spectrum, and a UV-visible spectrum analysis, in addition to the magnetic properties being measured. The measurements of the molar conductance implieda nonelectrolytic nature of compounds Co(II) and Ni(II). The magnetic susceptibility, as well as electronic spectra, represented all the metal complexesthroughoctahedral geometry, respectively. The PXRD patterns suggested that all the complexes were an orthorhombic system with unit cell parameters. The in-vitro biological activity of the ligand and the metal complexes were screened against the Gram-positive and negative pathogenic bacteria Staphylococcus aureus, Bacillus subtilis, Pseudomonas, aeruginosa and Escherichia coli, as well as the fungal species of Aspergillusniger and Candida albicans.Thus, the metal complexes showeda high efficiency of antimicrobial activity compared with the ligand. Furthermore, applications of the ligand, as well as the metal complexes, were tested for in-vitro antioxidant potential in aDPPH assay. The results showed that the activity of the metal complexes with the in-vitro antioxidant was more active than that of 2,4-dinitrophenylhydrazine(DNPH).

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New mixed ligand copper(II) hydrazone‐based complexes: Synthesis, characterization, crystal structure, DNA/RNA/BSA binding, in vitro anticancer, apoptotic activity, and cell cycle analysis

Elsayed

Elnabky

Biase

et al. 2021

Applied Organom Chemis

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Four new mixed ligand copper(II) complexes with the general formula [Cu(L) (B)] n (1)-( 4) (H 2 L = dehydroacetic acid benzoyl hydrazone Schiff base, B = H 2 O (1), DMSO (2), imidazole (imz) (3), n = 1) or pyridine (py) (4), n = 2) were synthesized. Characterization was performed by elemental analyses, FTIR, 1 H NMR, electron paramagnetic resonance (EPR), ESI-mass, and UV-visible) spectroscopy, together with magnetic susceptibility and molar conductivity measurements. The molecular structure of ( 2) and ( 4) complexes was investigated by X-ray crystallography. The ligand behaves as a di-basic tridentate ONO donor, coordinating to copper(II) center via deprotonated hydroxyl group, azomethine nitrogen, and deprotonated amide oxygen in a square planar (1)-(3) /square pyramidal geometry (4). The intercalation binding mode of the compounds with calf thymus DNA (ct DNA) and yeast (tRNA) and strong static interaction with bovine serum albumin (BSA) protein have been evaluated by absorption and emission spectroscopy. Further, in vitro cytotoxic activity of the compounds was examined on three human cancer cell lines; breast cancer (MCF7), colon cancer (HCT116), liver cancer (HepG2), and a normal lung fibroblast cell line (WI38) using cisplatin as a standard. Based on IC 50 and therapeutic indices (TI), complexes (3) and (4) showed better activity than that of cisplatin. So both complexes were subjected for further studies viz, DNA fragmentation, cell apoptosis (annexin), and cell cycle analysis. They induced DNA fragmentation, and the HCT116 and HePG2 cell death were induced using (3) and (4) complexes, respectively, by apoptosis and cell cycle arrest at the G2/M phase.

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Preparation, characterization of some transition metal complexes of hydrazone derivatives and their antibacterial and antioxidant activities

Cited by 73 publications

References 75 publications

Quantum chemical studies and effect of gamma irradiation on the spectral, thermal, X‐ray diffraction and DNA interaction with Pd (II), Cu(I), and Cd (II) of hydrazone derivatives

Quantum chemical studies and effect of gamma irradiation on the spectral, thermal, X‐ray diffraction and DNA interaction with Pd (II), Cu(I), and Cd (II) of hydrazone derivatives

Synthesis, Spectral Characterization and Biological Activities of Co(II) and Ni(II) Mixed Ligand Complexes

New mixed ligand copper(II) hydrazone‐based complexes: Synthesis, characterization, crystal structure, DNA/RNA/BSA binding, in vitro anticancer, apoptotic activity, and cell cycle analysis

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