Preparation, characterization, release and antioxidant activity of curcumin-loaded amorphous calcium phosphate nanoparticles

Guo, Xia; Li, Wenfeng; Wang, Heping; Fan, Yanying; Wang, Hong; Gao, Xianghua; Niu, Baolong; Gong, Xuechen

doi:10.1016/j.jnoncrysol.2018.08.015

Cited by 36 publications

(17 citation statements)

References 37 publications

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“…These results demonstrate that the encapsulation of curcumin by DBS-NPs exhibited more efficiently on scavenging free radicals than the free curcumin. This could be due to the low solubility of curcumin lowering the quantity of reactant molecules . In addition, the enhancement of dispersibility and surface area after curcumin encapsulation, which strengthened the interactions between curcumins and free radicals .…”

Section: Resultssupporting

confidence: 63%

Section: Resultsmentioning

confidence: 61%

“…Because of the phenolic hydroxyl (−OH) groups, curcumin had strong antioxidant activity, and the antioxidant capacity was dependent on the binding efficiency between free radicals and −OH groups. 59 Therefore, the antioxidant activity of free curcumin and curcumin-loaded DBS-NPs was evaluated by a DPPH free radical scavenging activity (Figure 6). Significant increase (p < 0.05) in antioxidant activity of curcumin was efficiently displayed by the IC 50 (50% inhibitory concentration) values for the encapsulated curcumin in DBS-NPs (Figure 6).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Effects of Degree of Polymerization on Size, Crystal Structure, and Digestibility of Debranched Starch Nanoparticles and Their Enhanced Antioxidant and Antibacterial Activities of Curcumin

Qin

Wang

Qiu

et al. 2019

ACS Sustainable Chem. Eng.

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The versatility of debranched starch nanoparticles (DBS-NPs) has attracted considerable attention from the food, agricultural, and cosmetic industries. The aim of this study was to investigate the effect of DBSs with low (DP < 10), moderate (10 > DP < 20), and high (20 > DP < 25) DPs (where DP represents the degree of polymerization), as well as reaction temperatures (25, 60, and 90 °C) on size, morphology, crystal structure, and digestibility of the refined DBS-NPs via nanoprecipitation. Spherical DBS-NPs with a controlled size of 40–200 nm were obtained; no nanoparticles were observed when the average DP was <10. The relative crystallinity increased from 11.1% to 71.6% as the increasing the average DP increased. When the microsized DBSs were converted to nanoscale DBSs, the rapidly digestible starch levels of the DBS-NPs decreased, and the DBS-NPs showed remarkable increase in the sum of slowly digestible starch and resistant starch contents, compared to the responding DBS. Furthermore, the maximum encapsulation efficiency of curcumin in DBS-NPs reached up to 92.49%. The antioxidant and antibacterial activities of curcumins in DBS-NPs were enhanced significantly, and their antioxidant stability was improved markedly when exposed to UV light or heat treatments.

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Section: Resultssupporting

confidence: 63%

Section: Resultsmentioning

confidence: 61%

Section: ■ Results and Discussionmentioning

confidence: 99%

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Effects of Degree of Polymerization on Size, Crystal Structure, and Digestibility of Debranched Starch Nanoparticles and Their Enhanced Antioxidant and Antibacterial Activities of Curcumin

Qin

Wang

Qiu

et al. 2019

ACS Sustainable Chem. Eng.

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“…Hyaluronic acid, as a possibility in order to enhance the stability of amorphous calcium phosphate, has been investigated. The electrostatic complex formed between the anionic carboxyl group and cationic Ca 2+ of hyaluronic acid and amorphous calcium phosphate, respectively, was explored [ 97 , 98 , 99 ]. Further, sodium hyaluronic acid- amorphous calcium phosphate -hexametaphosphate complex has managed to show the stability of dispersion in terms of uniform dispersity for up to 3 months, hence the agglomeration problem has been solved.…”

Section: Strategies In Bone Targetingmentioning

confidence: 99%

Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

et al. 2022

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Bone metastasis has been considered the fatal phase of cancers, which remains incurable and to be a challenge due to the non-availability of the ideal treatment strategy. Unlike bone cancer, bone metastasis involves the spreading of the tumor cells to the bones from different origins. Bone metastasis generally originates from breast and prostate cancers. The possibility of bone metastasis is highly attributable to its physiological milieu susceptible to tumor growth. The treatment of bone-related diseases has multiple complications, including bone breakage, reduced quality of life, spinal cord or nerve compression, and pain. However, anticancer active agents have failed to maintain desired therapeutic concentrations at the target site; hence, uptake of the drug takes place at a non-target site responsible for the toxicity at the cellular level. Interestingly, lipid-based drug delivery systems have become the center of interest for researchers, thanks to their biocompatible and bio-mimetic nature. These systems possess a great potential to improve precise bone targeting without affecting healthy tissues. The lipid nano-sized systems are not only limited to delivering active agents but also genes/peptide sequences/siRNA, bisphosphonates, etc. Additionally, lipid coating of inorganic nanomaterials such as calcium phosphate is an effective approach against uncontrollable rapid precipitation resulting in reduced colloidal stability and dispersity. This review summarizes the numerous aspects, including development, design, possible applications, challenges, and future perspective of lipid nano-transporters, namely liposomes, exosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoparticulate gels to treat bone metastasis and induce bone regeneration. Additionally, the economic suitability of these systems has been discussed and different alternatives have been discussed. All in all, through this review we will try to understand how far nanomedicine is from clinical and industrial applications in bone metastasis.

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“…The solubility and bioavailability of gold nanoparticles were increased when they were conjugated with curcumin resulting in the least extent of cytotoxicity and increased antioxidant activity [16]. The curcumin‐loaded Amorphous Calcium Phosphate nanoparticles have improved free radical scavenging capability and high antioxidant activity [17]. In the previous study, it was depicted that curcumin‐loaded chitosan nanoparticles were used for the antiproliferative activity of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

Assessment of antibacterial and antifungal potential of Curcuma longa and synthesized nanoparticles: A comparative study

et al. 2021

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Curcumin nanoparticles were most recently considered in medical research because of their antibacterial properties. The main objective of the study was to develop the green synthesis and antibacterial activity of curcumin nanoparticles using Curcuma longa. The processing of curcumin nanoparticles was carried out after the collection, identification, and extraction of curcumin. The effect of a sample on the synthesis of nanoparticles, such as curcumin aqueous concentrations (5, 10, and 20 mg/ml) and curcumin nanoparticles (5, 10, and 20 mg/ml), and the antibacterial effect of these nanoparticles on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and the fungal strain Aspergillus niger. For examining antibacterial and anti‐fungal activity disc diffusion method was performed, followed by the zone of inhibition. According to X‐ray diffraction and scanning electron microscope analysis, nanoparticles have spherical shapes and size of 42.64 nm. Results showed that a high dose of 20 mg/ml curcumin nanoparticles have more antibacterial activity than curcumin extracts in E. coli as it showed the largest diameter of zone of inhibition as compared to other doses. Other bacterial and fungal strains also showed significant results but E. coli was most prominent. The biosynthesis of curcumin nanoparticles using an aqueous extract of C. longa is a clean, inexpensive, and safe method that has not been used any toxic substance and consequently does not have side effects. Since several pathogenic species have acquired antibiotic resistance, the combination of curcumin with various nanoparticles would be beneficial in the cure of pathogenic diseases.

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Preparation, characterization, release and antioxidant activity of curcumin-loaded amorphous calcium phosphate nanoparticles

Cited by 36 publications

References 37 publications

Effects of Degree of Polymerization on Size, Crystal Structure, and Digestibility of Debranched Starch Nanoparticles and Their Enhanced Antioxidant and Antibacterial Activities of Curcumin

Effects of Degree of Polymerization on Size, Crystal Structure, and Digestibility of Debranched Starch Nanoparticles and Their Enhanced Antioxidant and Antibacterial Activities of Curcumin

Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

Assessment of antibacterial and antifungal potential of Curcuma longa and synthesized nanoparticles: A comparative study

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