Preparation of a hydroxypropyl-β-cyclodextrin functionalized monolithic column by one-pot sequential reaction and its application for capillary electrochromatographic enantiomer separation

Preparation of a novel hydroxypropyl‐γ‐cyclodextrin functionalized monolith for separation of chiral drugs in capillary electrochromatography

“…Our group has previously reported the fabrication of the HP‐β‐CD functionalized monolith by the same strategy 25 . Table S2 summarizes enantioseparation results of chiral drugs on the HP‐γ‐CD and HP‐β‐CD functionalized monoliths.…”

“…However, CDs in the mobile phase result in relatively low sensitivity with a high consumption of chemicals. Since the discovery of the advantageous property of monoliths, attempts have been made to explore β‐CD‐based monolithic stationary phase for enantiomer separation 19–26 . With the promising development, new CD derivatives functionalized monoliths need to be prepared in order to achieve altered enantioselectivities and further broaden the application range.…”

“…In this work, a novel HP‐γ‐CD functionalized monolith was developed and tested in CEC chiral separation for the first time. A simple and efficient one‐pot sequential strategy previously reported by our group 24,25 was used for preparation of the monolith. In one pot, HP‐γ‐CD functional monomer was allowed to be formed via the ring opening reaction of HP‐γ‐CD with glycidyl methacrylate (GMA) and then directly copolymerized with comonomer and crosslinker to form the final monolith.…”

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

“…In “one‐pot” approach, complex molecules can be obtained from relatively simple materials by many reaction steps, without separation of intermediates . Deng and co‐workers have introduced a hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) functionalized monolithic column for chiral separation by a simple and efficient in situ copolymerization of glycidyl methacrylate‐HP‐β‐CD as the functional monomer and ethylene dimethacrylate (EDMA) as the crosslinker. The column possessed uniform structure, good permeability, high mechanical stability, and excellent chiral separation ability for various kinds of chiral analytes.…”

Intermolecular interactions between β-cyclodextrin and water

“…Moreover, the hydrophilic exterior of its cavity makes b-cyclodextrin exhibit good interactions with hydrophilic substances, and thus it has been used in the elds of drug delivery, pollutant removal and synthesis of new materials. [11][12][13][14][15] The role of water is important to accurately understand the transfer of small molecules to bcyclodextrin and the intermolecular interactions between bcyclodextrin and other species besides water. Therefore, it is necessary to accurately investigate the intermolecular interactions between b-cyclodextrin and water.…”