Preparation of bicyclic lactones using lewis acids catalyzed ene-reaction

Stereoselective Synthesis of Bicyclic Lactones Via Annelation Protocol

“…In particu lar, the γ-butyrolactone mo iety is a recurrent feature of many naturally occurring substances examp les are brasoside and littoralissone. 1,2 The synthetic approaches to th is b icyclic lactones have been imaginative and numerous, [3][4][5][6][7][8] there is a continued demand fo r efficien t methods fo r the assemb ling o f these key co mp o u n d s wh ich g iv e es p ec ia lly h ig h lev e ls o f stereoselectivity. In this report, it is reported some of our preliminary resu lts in the estab lish ment o f an effect ive met h odo logy fo r th e const ruct io n o f t hes e impo rtant compounds.…”