Preparation of high specific activity radiotracers for radioanalytical studies

Gallorini, M.; Birattari, C.; Bonardi, M.; Magon, L.; Sabbioni, E.

doi:10.1007/bf02037130

Cited by 23 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The [ 48 V]vanadium tracer with a half-life of 15.97 d and gamma radiation energies of 511.0, 983.5 and 1312.1 keV was produced by irradiation of a titanium foil with 15 MeV protons, accelerated by the isochronous cyclotron (CGR MeV 520, Buc, France) of Ghent University [20]. Using a 0.5 mm titanium foil the proton energy degrades to 9 MeV, which provides a good compromise for high 48 V activity and low titanium mass.…”

Section: Vanadium-48 Tracer: Preparation and Radioactivity Measurementsmentioning

confidence: 99%

Fractionation of vanadium complexes in serum, packed cells and tissues of Wistar rats by means of gel filtration and anion-exchange chromatography

et al. 2002

View full text Add to dashboard Cite

Male Wistar rats were intraperitoneally injected with [(48)V]vanadium tracer to (1) investigate the distribution of vanadium over different tissues and (2) study the distribution of vanadium over the proteins and peptides in serum, packed cells and homogenates of tissues by means of liquid chromatography experiments (size exclusion, ion exchange). Target organs were primarily kidney, bone, spleen and liver. In serum we found that vanadium was mainly bound to transferrin; however, a small amount was also bound to albumin. Besides these two complexes, a significant part of vanadium occurred as readily exchangeable ("free") vanadium. In packed cells, vanadium is mainly bound to hemoglobin and to two abundant low molecular mass complexes. The chromatograms of tissues (kidney, liver, testes, spleen and lung) show similar high molecular mass complexes (vanadium co-elutes with ferritin, transferrin and hemoglobin). Between the low molecular mass complexes there are similar peaks for spleen, testes and kidneys on the one hand, and liver and lung on the other hand, albeit the differences are small. In the case of lung, there is an additional low molecular mass peak.

show abstract

Section: Vanadium-48 Tracer: Preparation and Radioactivity Measurementsmentioning

confidence: 99%

Fractionation of vanadium complexes in serum, packed cells and tissues of Wistar rats by means of gel filtration and anion-exchange chromatography

et al. 2002

View full text Add to dashboard Cite

show abstract

“…[15][16][17] However, simultaneous production and separation of carrier-free isotopes of mercury and gold in charged particle activated target matrix have not been reported earlier. (T1/2=3.8 h) and 193mHg (7'1/2 = 11.8 h) have shorter half-lives compared to 2~ and 197Hg, which may be preferred from a view point of in vivo applications as the q-energies, intensities, etc., of these isotopes are favorable for medicinal applications.…”

Section: Introductionmentioning

confidence: 99%