Preparation of lectin-vicilin nanoparticle conjugates using the carbodiimide coupling technique

Ezpeleta, I.; Irache, Juan M.; Stainmesse, Serge; Chabenat, Christiane; Guéguen, Jacques; Orecchioni, A. M.

doi:10.1016/0378-5173(96)04668-6

Cited by 31 publications

(4 citation statements)

References 25 publications

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“…An amide bound to N-glut-PE as membrane anchor was used for coupling of antibody to the liposome surface (15) because, compared to other techniques, this method (under neutral conditions) offers a good coupling efficiency (4). The free amino groups of proteins are linked to the carboxylic carrier in the presence of water-soluble carbodiimide; it is not required to modify the protein before coupling.…”

Section: Preparation Of Antibody Coupled Liposomesmentioning

confidence: 99%

Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells—A Potential Tool for Specific Drug Delivery

Voinea¹,

Manduteanu²,

Dragomir³

et al. 2005

Pharm Res

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Section: Preparation Of Antibody Coupled Liposomesmentioning

confidence: 99%

Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells—A Potential Tool for Specific Drug Delivery

Voinea¹,

Manduteanu²,

Dragomir³

et al. 2005

Pharm Res

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“…Moreover, Sonekar et al used the desolvation method to prepare folic acid–curcumin–gliadin nanoparticles, and the results showed that the delivery vehicle could enhance the oral delivery efficiency and target colon cancer cells capacity of curcumin [ 100 ]. Furthermore, the combination of anionic polysaccharides and gliadin could prevent the aggregation of gliadin nanoparticles and improve their stability [ 101 ]. Lectin is widely used in drug delivery because it can significantly improve drug absorption and enhance sugar-targeting ability.…”

Section: Application Of Bioactive Substances Loaded On Plant Protein-...mentioning

confidence: 99%

“…In addition, lectin-coated nanoparticles could stimulate the endocytosis of intestinal cells to transport nanoparticles out of cells, thus entering the blood circulation [ 99 ]. Moreover, lectin could combine with solid liposomes [ 100 ], proteins [ 101 ], and poly (lactic acid glycolic acid) copolymers [ 102 ] to form various types of nano carriers.…”

Section: Application Of Bioactive Substances Loaded On Plant Protein-...mentioning

confidence: 99%

New Perspective on Natural Plant Protein-Based Nanocarriers for Bioactive Ingredients Delivery

Wen

Zhang

et al. 2022

Foods

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The health effects of bioactive substances in the human body are affected by several factors, including food processing conditions, storage conditions, light and heat, among others. These factors greatly limit the stability and bioavailability of bioactive substances. These problems can be solved by a novel protein-based nanocarrier technology, which has the excellent potential to enhance solubility, bioavailability, and the controlled release of bioactive substances. In addition, plant protein has the advantages of economy, environmental protection, and high nutrition compared to animal protein. In this review, the preparation, characterization, and application of plant protein-based nanocarriers are summarized. The research deficiency and future prospects of plant protein nanocarriers are emphasized.

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“…Vicilin NPs have been prepared and used as drug carriers in a complex system in which these particles were conjugated with UIex europaeus lectin molecules due to their sugar-binding property via a two-stage carbodiimide method. The NPs had an average diameter of approximately 660 nm and the proposed delivery system was used in-vitro studies which revealed high potential of the prepared conjugate toward bovine submaxillary gland mucin (BSM) glycoprotein as a biological model (127).…”

Section: - Legume Proteinsmentioning

confidence: 99%

Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems

Malekzad

Mirshekari

Zangabad

et al. 2017

Critical Reviews in Biotechnology

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For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble protein from wheat and corn; legumin is a casein-like protein from leguminous seeds such as peas; lectins are glycoproteins naturally occurring in many plants that recognize specific carbohydrate residues. NPs formed from these proteins show good biocompatibility, possess the ability to enhance solubility, and provide sustained release of drugs and reduce their toxicity and side effects. The effects of preparation methods on the size and loading capacity of these NPs are also described in this review.

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Preparation of lectin-vicilin nanoparticle conjugates using the carbodiimide coupling technique

Cited by 31 publications

References 25 publications

Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells—A Potential Tool for Specific Drug Delivery

Immunoliposomes Directed Toward VCAM-1 Interact Specifically with Activated Endothelial Cells—A Potential Tool for Specific Drug Delivery

New Perspective on Natural Plant Protein-Based Nanocarriers for Bioactive Ingredients Delivery

Plant protein-based hydrophobic fine and ultrafine carrier particles in drug delivery systems

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