Preparation of quantum dots encoded microspheres by electrospray for the detection of biomolecules

Sun, Lei; Yu, Xiaofang; Sun, Mingda; Wang, Heng‐guo; Xu, Shufei; Dixon, John; Wang, Y. Andrew; Li, Yaoxian; Yang, Qingbiao; Xu, Xiaoyi

doi:10.1016/j.jcis.2011.02.047

Cited by 31 publications

(21 citation statements)

References 58 publications

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“…Yun et al (2009) fabricated nonagglomerated and monodispersed TiO 2 -poly(methyl methacrylate) (PMMA) composite microspheres with a mean diameter ranging from 0.25 to 1.87 μm using a combination of beads mill and electrospray techniques. Sun et al (2011) fabricated quantum dot (CdSeS QDs)-encoded poly(styrene-acrylate) microspheres by electrospraying the mixture of polymer solution and quantum dots solution, providing many reliable codes for multiplex detection. In different studies, Park et al (2011, 2012b, 2013) demonstrated the fabrication of PVA/MMT, PVA/Ag, and PVA/MMT/Ag composite particles using electrospray and explored the test of antibacterial activity against Staphylococcus aureus .…”

Section: Compositionmentioning

confidence: 99%

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

Xie

Jiang

Davoodi

et al. 2015

Chemical Engineering Science

268

159

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Electrohydrodynamic atomization (EHDA), also called electrospray technique, has been studied for more than one century. However, since 1990s it has begun to be used to produce and process micro-/nanostructured materials. Owing to the simplicity and flexibility in EHDA experimental setup, it has been successfully employed to generate particulate materials with controllable compositions, structures, sizes, morphologies, and shapes. EHDA has also been used to deposit micro- and nanoparticulate materials on surfaces in a well-controlled manner. All these attributes make EHDA a fascinating tool for preparing and assembling a wide range of micro- and nanostructured materials which have been exploited for use in pharmaceutics, food, and healthcare to name a few. Our goal is to review this field, which allows scientists and engineers to learn about the EHDA technique and how it might be used to create, process, and assemble micro-/nanoparticulate materials with unique and intriguing properties. We begin with a brief introduction to the mechanism and setup of EHDA technique. We then discuss issues critical to successful application of EHDA technique, including control of composition, size, shape, morphology, structure of particulate materials and their assembly. We also illustrate a few of the many potential applications of particulate materials, especially in the area of drug delivery and regenerative medicine. Next, we review the simulation and modeling of Taylor cone-jet formation for a single and co-axial nozzle. The mathematical modeling of particle transport and deposition is presented to provide a deeper understanding of the effective parameters in the preparation, collection and pattering processes. We conclude this article with a discussion on perspectives and future possibilities in this field.

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Section: Compositionmentioning

confidence: 99%

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

Xie

Jiang

Davoodi

et al. 2015

Chemical Engineering Science

268

159

View full text Add to dashboard Cite

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“…With the development of nanotechnology, it is increasingly concerned in many scientific fields such as chemical engineering, materials science and pharmacology. [9][10][11] Several electrospun fibrous membrane chemosensors for specific analytes (such as metal ions, anions, poisonous gas, etc.) were designed and synthesized in recent years, which were featured with large specific surface area, high porosity and good interconnectivity.…”

Section: Introductionmentioning

confidence: 99%

A Novel Nanofibrous Film Chemosensor for Highly Selective and Sensitive Optical Signaling of Zn2+

Zhou

Liu

2017

J. Braz. Chem. Soc.

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A novel nanofibrous film chemosensor was fabricated by copolymerization and electrospinning, which exhibited signaling behaviors for Zn 2+ . Upon addition of Zn 2+ , the sensor film exhibited obvious fluorescence enhancement in a linear fashion. Owing to a larger surface area and high permeability, the selectivity and sensitivity of the nanofibrous film for Zn 2+ were satisfactory and achieving a limit of detection of 1.95 × 10 -5 mol L -1. Moreover, this material could serve as an adsorbent for Zn 2+ , as the adsorption capacity was 11.45 mg of Zn 2+ ions per gram of nanofibrous film.

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“…165,191,192 Previous work has shown that it is capable of producing uniform microspheres with sizes ranging from nano to micron. 190 Couzis et al 165 produced 50 μm QD barcodes using a spraying-suspension polymerization method (see Fig.…”

Section: Fabrication Technologies For Nanoparticle-tagged Barcodesmentioning

confidence: 99%

Suspension arrays based on nanoparticle-encoded microspheres for high-throughput multiplexed detection

et al. 2015

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Spectrometrically or optically encoded microsphere based suspension array technology (SAT) is applicable to the high-throughput, simultaneous detection of multiple analytes within a small, single sample volume. Thanks to the rapid development of nanotechnology, tremendous progress has been made in the multiplexed detecting capability, sensitivity, and photostability of suspension arrays. In this review, we first focus on the current stock of nanoparticle-based barcodes as well as the manufacturing technologies required for their production. We then move on to discuss all existing barcode-based bioanalysis patterns, including the various labels used in suspension arrays, label-free platforms, signal amplification methods, and fluorescence resonance energy transfer (FRET)-based platforms. We then introduce automatic platforms for suspension arrays that use superparamagnetic nanoparticle-based microspheres. Finally, we summarize the current challenges and their proposed solutions, which are centered on improving encoding capacities, alternative probe possibilities, nonspecificity suppression, directional immobilization, and “point of care” platforms. Throughout this review, we aim to provide a comprehensive guide for the design of suspension arrays, with the goal of improving their performance in areas such as multiplexing capacity, throughput, sensitivity, and cost effectiveness. We hope that our summary on the state-of-the-art development of these arrays, our commentary on future challenges, and some proposed avenues for further advances will help drive the development of suspension array technology and its related fields.

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Preparation of quantum dots encoded microspheres by electrospray for the detection of biomolecules

Cited by 31 publications

References 58 publications

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

Electrohydrodynamic atomization: A two-decade effort to produce and process micro-/nanoparticulate materials

A Novel Nanofibrous Film Chemosensor for Highly Selective and Sensitive Optical Signaling of Zn2+

Suspension arrays based on nanoparticle-encoded microspheres for high-throughput multiplexed detection

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