Preparation of Synthetic Immune Serum and Nature of Immunity

BACON, DONALD K.

doi:10.1001/archinte.1943.00210110018002

Cited by 3 publications

(1 citation statement)

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“…Evidence is incomplete as to what tissues or cells cannot form them and occasionally authors believe that an essential part of their synthesis occurs in the blood [Bacon (168)]. The outstanding contribution of the older literature is the demonstration that extirpation of the spleen frequently lowers acquired immunity including the formation of specific antibodies (9,10,11).…”

Section: Site Of Antibody Formationmentioning

confidence: 99%

The Cellular Basis of Immunity

Taliaferro¹

1949

Annu. Rev. Microbiol.

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Once invading organisms or other antigenic materials have passed or have been introduced beyond the epithelial or mechani cal barriers, their localization and disposal is a part of local (local inflammation) and general defense reactions. The main functional roles of the cells involved in these reactions are (a) to remove foreign material by extra-or intracellular digestion (phagocytosis) or to isolate it by a connective tissue wall (encapsulation); (b) to perform various reparative processes; and (c) to produce specific antibodies. With the exception of that part of repair which involves the parenchyma, the cells involved belong almost exclusively to the connective tissue, especially to the blood and lymph, to the reticular and loose connective tissues, and to the lamina propria and interstitial connective tissues of various organs including the brain. The cells are important to varying degrees in immunity be cause (a) they are ubiquitous in distribution or are easily mobilized via the blood stream; (b) they are phagocytic and/or possess potent digestive enzymes; and (c) they form a mesenchymal reserve in the postnatal vertebrate by retaining varying degrees of their embryonic power to develop into other cells of the connective tissue. These cells have other functions. As a whole, they take part in such diverse processes as intermediate metabolism, storage and mechanical support. A review of the functions of the reticulo endothelial system is given by Jaffe (1) and of the leucocytes by Rebuck (2) The present review stresses work of immediate interest to immunologists. It also outlines briefly the cells involved and their interrelationships because both subjects are fundamental to an understanding of the cellular aspects of immunity. The coverage, as a result, although largely limited to the last 10 years, has been selective, particularly as regards the latter aim, and includes some older work for purposes of orientation. CONNECTIVE TISSUE CELLS INVOLVED IN IMMUNITYThe cells involved in immunity are listed in Table I together with the systems into which they have been incorporated (d. 3) 159 Annu. Rev. Microbiol. 1949.3:159-194. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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Section: Site Of Antibody Formationmentioning

confidence: 99%