Preparation of Ultrathin Self-Standing Polyelectrolyte Multilayer Membranes at Physiological Conditions Using pH-Responsive Film Segments as Sacrificial Layers

Ono, Shoko; Decher, Gero

doi:10.1021/nl0515504

Cited by 139 publications

(198 citation statements)

References 59 publications

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“…86 Similar to microscale fabrication, a wide variety of nanofabrication techniques have emerged in recent years. Examples of successful 2D and 3D nanofabrication techniques include electrospinning, [195][196][197][198][199] nanotemplating, 179,200 electrostatic spray deposition, 201,202 RF plasma spray/deposition, 203 molecular self assembly, [204][205][206] and metal oxide anodization. 104,182,[207][208][209] Of the fabrication techniques listed above, electrospinning has emerged as a very promising strategy for fabricating bone-mimetic nanofiber scaffolds.…”

Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

685

499

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“…[30][31][32][33][34][35] Very recently, Ono and Decher have obtained a free-standing polyelectrolyte multilayer with a few centimeter square size by using a suitable sacrificial layer. 36 The thickness of this film is estimated roughly to be 250 nm from the reported number of the deposition cycle. Unfortunately, these LbL methods could give nanofilms (thickness 30-70 nm) with few tens to few hundreds of nanometers, as summarized by Jiang and Tsukruk.…”

Section: Nanomembrane Formation By Layer-by-layer Assemblymentioning

confidence: 99%

Development of Fabrication of Giant Nanomembranes

Watanabe

Vendamme

Kunitake

2007

Bulletin of the Chemical Society of Japan

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Large nanomembranes, which are characterized by aspect ratios (size/thickness) of greater than one million, are described. The combination of nanometer thickness and macroscopic size facilitates important applications in materials separation, selective transport and electrochemical devices. In the past, only small pieces of nanomembranes have been fabricated, in spite of intensive research. We describe here the first examples of a general fabrication procedure. Spin coating of the precursor solutions on appropriate underlayer was effectively used to prepare 10-30 nm thick nanomembranes of metal oxides, interpenetrating network of cross-linked acrylate with metal oxide, and highly cross-linked organic polymers (epoxy resin, etc.). The underlayer is composed of an affinity (e.g., poly(vinyl alcohol)) layer and/ or sacrificial layer, and the role of these layers is discussed. Some of the mechanical properties of nanomembranes were measured by using a bulge test and a compression method. The nanomembranes of the organic and inorganic hybrids and the purely organic resins were surprisingly robust and defect-free.

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“…However, evaluation of the ion permeability of support-free LbL films would be of significant importance. In this context, Ono and Decher recently prepared free-standing LbL films composed of PAH and PSS using a decomposable sacrificial thin layer consisting of poly(acrylic acid) (PAA) and poly(ethylene glycol) (PEG) [36]. Robust LbL films can be produced by cross-linking polymer chains [37].…”

Section: Open Accessmentioning

confidence: 99%

Ion Permeability of Free-Suspended Layer-by-Layer (LbL) Films Prepared Using an Alginate Scaffold

2013

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Abstract:Layer-by-layer (LbL) films were prepared over an aperture (diameter 1-5 mm) on a glass plate to study ion permeation across free-suspended LbL films. LbL films were prepared by depositing alternating layers of poly(allylamine hydrochloride) (PAH) and poly(styrene sulfonate) (PSS) on the surface of a glass plate with an aperture filled with an alginate gel, followed by dissolution of the alginate gel. PAH-PSS films prepared in this way showed permeability to inorganic salts, depending on the size and charge. Permeability to alkali metal chlorides depended on the Stokes radius of the alkali metal cations. The effect of the type of halide was negligible because of the halides' smaller ionic radii. Permeation of multivalent ions such as Ru(NH 3 ) 6 3+ and [Fe(CN) 6 ] 3− was severely suppressed owing to Donnan exclusion.

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Preparation of Ultrathin Self-Standing Polyelectrolyte Multilayer Membranes at Physiological Conditions Using pH-Responsive Film Segments as Sacrificial Layers

Cited by 139 publications

References 59 publications

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Development of Fabrication of Giant Nanomembranes

Ion Permeability of Free-Suspended Layer-by-Layer (LbL) Films Prepared Using an Alginate Scaffold

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