Preparation, stability and antimicrobial activity of cationic cross-linked starch–iodine complexes

Klimavičiūtė, Rima; Bendoraitienė, Joana; Rutkaitė, Ramunė; Šiugždaitė, Jūratė; Zemaitaitis, Algirdas

doi:10.1016/j.ijbiomac.2012.07.025

Cited by 14 publications

(11 citation statements)

References 17 publications

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“…Metal cations, transition metals [18][19][20][21][22] and polymers have also gained interest in drug development and biocidal applications [23][24][25][26]. Povidone-iodine (polyvinylpyrrolidone-I 2 or PVP-I 2 ) is an effective disinfectant [6,27].…”

Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

“…Polymeric antibacterial agents have the ability to increase the long-term effectiveness and the stability of the biocidal agent [26,28]. Iodine in combination with naturally occurring polymeric biocides like chitosan and starch are toxic against microorganisms [2,26,28]. Long-term effectiveness and stability of the biocidal agent are important requirements.…”

Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

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“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

et al. 2019

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Antimicrobial agents containing symmetrical triiodides complexes with halogen bonding may release free iodine molecules in a controlled manner. This happens due to interactions with the plasma membrane of microorganisms which lead to changes in the structure of the triiodide anion. To verify this hypothesis, the triiodide complex [Na(12-crown-4)2]I3 was prepared by an optimized one-pot synthesis and tested against 18 clinical isolates, 10 reference strains of pathogens and five antibiotics. The antimicrobial activities of this symmetrical triiodide complex were determined by zone of inhibition plate studies through disc- and agar-well-diffusion methods. The triiodide complex proved to be a broad spectrum microbicidal agent. The biological activities were related to the calculated partition coefficient (octanol/water). The microstructural analysis of SEM and EDS undermined the purity of the triiodide complex. The anionic structure consists of isolated, symmetrical triiodide anions [I-I-I]- with halogen bonding. Computational methods were used to calculate the energy required to release iodine from [I-I-I]- and [I-I···I]-. The halogen bonding in the triiodide ion reduces the antibacterial activities in comparison to the inhibitory actions of pure iodine but increases the long term stability of [Na(12-crown-4)2]I3.

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Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

Section: I-i-i] − and [I-i•••i]mentioning

confidence: 99%

“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

et al. 2019

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“…Iodophors are chemical complexes that contain a mixture of molecular iodine, iodide ions, and a solubilizing agent [2]. Natural and synthetic water-soluble polymers and nonionic surfactants are broadly used as solubilizing agents.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Iodophors: Preparation, Properties, and Biomedical Applications

2020

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The review summarizes the data on the main chemical and physiological properties of iodine and its capability of complexation with natural and synthetic polymers. Iodine is the best known antiseptic used to prevent and treat microbial infections. Its unique capability of complexation with certain polymers opens wide opportunities for targeted and prolonged delivery to target organs. Polymeric complexes with iodine have another color, other morphology, a higher electrical conductivity, and higher biological activity as compared with initial polymers. The formation of and ions is associated with iodine–polymer complexation. Iodine-containing biocompatible adhesive controlled-release formulations are designed as part of research into iodine–polymer complexes. The field is promising in terms of treating certain diseases because tolerance to iodine compounds does not usually develop in microbial cells.

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“…In this context, inorganic antimicrobial agents, like the elements iodine, copper [15][16][17][18], and very recently both elements combined [19,20], as well as Li + , Na + , K + , other metal cations [21,22] and transition metals [23] have gained a growing interest in drug development and biocidal applications [24][25][26][27]. Especially iodine and copper are very essential to human health, nontoxic in most mammals, including humans, but have been approved and registered by the US Environmental Protection Agency (EPA) as antimicrobial agents and are used in many combinations in the food industry [17].…”

Section: Introductionmentioning

confidence: 99%

“…Polymeric antibacterial agents, the new field of investigations, have the ability to increase the long-term effectiveness and the stability of the biocidal agent [27]. In this regard, Iodine in combination with natural occurring polymeric biocides like starch are toxic against microorganisms [2,27,28]. Long term effectiveness and stability of the biocidal agent are important requirements.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antifungal Activity of the Triiodide [Na(12-Crown-4)2]I3 on the Pathogens Escherichia coli, Streptococcus pyogenes, Streptococcus faecalis, Bacillus subtilis, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae and Candida albicans

Edis¹,

Bloukh²,

Sara³

2017

Preprint

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New antibacterial agents are needed to overcome the increasing number of infectious diseases caused by pathogenic microorganisms due to the emergence of multi-drug resistant strains. In this context, halogens, especially Iodine is known since ages for its antimicrobial activity. Therefore, especially triiodides encapsulated in organometallic complexes can be helpful as new agents against microorganisms. The aims of this work was to study the biological activity of [Na(12-Crown-4)2]I3 against gram positive Streptococcus pyogenes, Streptococcus faecalis, the spore forming bacteria Bacillus subtilis and gram negative bacteria Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumoniae, as well as the yeast Candida albicans. The antimicrobial and antifungal activities of the triiodide were determined by zone of inhibition plate studies. [Na(12-Crown-4)2]I3 exhibited potent antimicrobial activity on gram positive Streptochocci and the yeast C. albicans. Furthermore, the gram negative bacteria P. aeruginosa and K. pneumoniae were less effectively inhibited, while E. coli and P. mirabilis proved to be even resistant.

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Preparation, stability and antimicrobial activity of cationic cross-linked starch–iodine complexes

Cited by 14 publications

References 17 publications

“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

“Smart” Triiodide Compounds: Does Halogen Bonding Influence Antimicrobial Activities?

Polymeric Iodophors: Preparation, Properties, and Biomedical Applications

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