Preparation, structural characterization, bioactivities, and applications of Crataegus spp. polysaccharides: A review

Cheng, Lei; Yang, Qiuli; Li, Chaohai; Zheng, Jiamei; Wang, Yaping; Duan, Baozhong

doi:10.1016/j.ijbiomac.2023.126671

Cited by 5 publications

(1 citation statement)

References 69 publications

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“…Hawthorn triterpenoid acid has a cholesterol-lowering effect by inhibiting intestinal cholesterol acyltransferase (ACAT) activity [23]. The versatility of hawthorn polysaccharides-recognized for their multiple benefits, including reducing blood lipid levels, anticancer, antibacterial, antioxidant, and immunomodulatory properties-in various health aspects has been previously demonstrated [24]. Hawthorn extract is beneficial to the inhibition of cancer.…”

Section: Introductionmentioning

confidence: 99%

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Wang,

Sun,

et al. 2024

Foods

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Colorectal carcinoma (CRC) is a major global health concern, with cancer metastasis being the main cause of patient mortality, and current CRC treatments are challenged by drug resistance. Although natural compounds, especially in foods like hawthorn proanthocyanidin extract (HPOE), have good anticancer activity, their effects on CRC metastasis remain unknown. Therefore, our objective was to investigate the impact and potential mechanisms of HPOE on the movement and infiltration of cells in the HCT116 CRC cells. Firstly, scratch-healing experiments confirmed the anti-migratory and anti-invasive capabilities of HPOE. Then, network pharmacology identified 16 possible targets, including MMP-9. Subsequently, RT-qPCR and Western blotting experiments confirmed that HPOE downregulated epithelial-mesenchymal transition-related factors (N-cadherin and MMP-9) and inhibited Wnt/β-catenin pathway activation. Finally, these results were experimentally validated using the Wnt pathway activator Licl and inhibitor XAV939. It was confirmed that HPOE had a certain inhibitory effect on the activation of the Wnt signaling pathway caused by the activator Licl and could enhance the inhibitory effect of the inhibitor XAV939. Our findings provide a basis for developing functional foods or dietary supplements, especially positioning HPOE as a functional food raw material for adjuvant treatment of CRC, given its ability to inhibit metastasis through the Wnt/β-catenin pathway.

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Section: Introductionmentioning

confidence: 99%