Preparation, structural elucidation and biocidal applications of trimethyltin(IV) complexes derived from substituted carboxylic acids

Abstract

A series of trimethyltin(IV) carboxylates (1-7) , having general formula [(CH 3 ) 3 SnOOCR], where R = 3-CF 3 C 6 H 4 - (1) , 3,4-(OCH 2 CH 3 ) 2 C 6 H 3 - (2) , 3-FC 6 H 4 - (3) , 4-ClC 6 H 5 - (4) , 2,4-(OCH 3 ) 2 C 6 H 3 - (5) , 4-NO 2 C 6 H 4 - (6) , 5-CH 3 C 4 H 2 N 2 - (7) have been synthesized and are characterized by using analytical techniques like, FT-IR, 1 H, 13 C and 119 Sn NMR spectroscopy in addition to elemental analyses. To validate the structural motif, one of the complex (2) was also analyzed by single crystal XRD technique. The single crystal X-ray diffraction analysis revealed that the molecular species exist in one dimensional polymeric chain, wherein five coordinated tin is attached to two oxygens of the carboxyl and three carbon atoms of CH 3 groups, whereas the bond angles for C-Sn-C (117.20–121.65°), C-Sn-O (87.87–98.60°) and O-Sn-O (173.75°) lie in the predictable range of distorted trigonal bipyramidal geometry. All the synthesized complexes were also subjected to preliminary screening for various biocidal applications such as antimicrobial, anti-diabetic, protein kinase inhibition and brine shrimp lethality test to check their efficacy. The compound 6 exhibits very good antibacterial activity having MIC value 6.25 μg/mL against K. pneumoniae , whereas antidiabetic and protein kinase inhibition data revealed that 1 and 2 may serve as good to moderately effective inhibitors, respectively.

Synthesis, structural analysis, electrochemical and magnetic properties of tetrachloroferrate ionic liquids

“…The designability of tetrachloroferrate as anions and an appropriate structural modification have opened a new dimension to the ionic liquids and their applications in various fields. Keeping these aspects in view and in continuation to our earlier work [23][24] , we report herein the synthesis, structural elucidation of iron incorporated MILs to further explore their utilities in diverse field of studies. Their unique characteristics such as wide range of physico-chemical properties, high conductivities and magnetic susceptibility data could be exploited in electrical as well magnetic separation techniques in addition to synthetic chemistry.…”

Trimethyltin(IV) Bearing 3-(4-Methyl-2-oxoquinolin-1(2H)-yl)propanoate Causes Lipid Peroxidation-Mediated Autophagic Cell Death in Human Melanoma A375 Cells

“…The 119 Sn NMR spectrum for Me 3 SnL showed tin resonance at 130 ppm, suggesting tetrahedral geometry around the tin atom in non-polar solvents, and this is in agreement with other tetracoordinated trimethyltin(IV) carboxylates [ 45 ]. However, in DMSO-d 6 , the chemical shift for tin was found at −106 ppm, indicating trigonal bipyramidal geometry [ 47 ].…”