Preparation, structural elucidation, molecular weight determination, and molecular recognition of first‐ and second‐tier dendrimer molecules

Abstract

1,3,5-Triglyceratetriazine [first tier (G 1 )] and tri(1,3,5-triglycerate) triazine [second tier (G 2 )] dendrimers were prepared with 1,3,5-trichlorotriazine and sodium glycerate in a 1 : 3 mass ratio in an ethanolic medium. G 1 and G 2 were amorphous, white, solid substances. Their structures were elucidated with IR, 1 H-NMR, and 13 C-NMR, and their thermal stability was studied with thermogravimetric analysis. The activation energy was calculated with the Freeman-Carroll model. Densities, viscosities, and surface tensions for 0.01-0.08 mol/kg aqueous solutions increased at 0.01 mol/kg for sodium glycerate, 1,3,5-trichlorotriazine, 1,3,5-triazine triglycerate chloride, G 1 , and G 2 . These values were measured at 298.15 K. The apparent molal volume, reduced viscosity, and inherent viscosity were calculated from the densities and viscosities, respectively. The data were regressed for the limiting densities, limiting apparent molal volumes, intrinsic viscosities, limiting inherent viscosities, and limiting surface tensions for solutesolvent interactions. The positive limiting apparent molal volume values were noted in the order of G 2 > 1,3,5-triazine triglycerate chloride > G 1 > 1,3,5-trichlorotriazine > sodium glycerate, with weaker hydrophilic intermolecular interactions of G 2 . The higher intrinsic viscosity and limiting inherent viscosity values for G 2 implied stronger G 2 -H 2 O hydrophilic interactions, and the higher limiting apparent molal volume of G 2 indicated slightly higher dynamic conformational changes in comparison with G 1 , with stronger structural activities.

Closing capacity of cranial bone defects using porous calcium phosphate cement implants in a rabbit animal model

“…The melamine ring in the resin macromolecule occupied a centermost location referred to as a core22. An expression of the C atom of the melamine ring at core is totally shattered as the ring is embedded in the deepest zone with respect to the growth of the resin with N(CH 2 O) 2 C pyrrolidone ring which acts as dendrimer units23. The O atom of the N(CH 2 O) 2 Cpyrrolidone ring also influenced the C electron density.…”

Preparation and characterization of melamine–formaldehyde–polyvinylpyrrolidone polymer resin for better industrial uses over melamine resins

“…The melamine ring in the resin macromolecule occupied a centermost location referred to as a core 22 . An expression of the C atom of the melamine ring at core is totally shattered as the ring is embedded in the deepest zone with respect to the growth of the resin with NA(CH 2 AO) 2 ACA pyrrolidone ring which acts as dendrimer units 23 . The O atom of the ANA(CH 2 AO) 2 CApyrrolidone ring also influenced the C electron density.…”

Silibinin binding and release activities moderated by interstices of trimesoyl, tridimethyl, and tridiethyl malonate first‐tier dendrimers

“…Therefore, the dendrimers as vehicles must not react or damage drug structures during the binding and carrying processes. Singh et al 6,11 reported 2,4,6-tridiethyl malonate triazine (TDEMTA), 2,4,6-hexadiethyl malonate triazine (HDEMTA), 1,3,5-triglyceratetriazine, and tri(1,3,5-triglycerate) triazine dendrimers with certain safer binding molecules, such as poly(vinyl pyrrolidone), glycerol, and sodium diethyl malonate esters (SDEME). With this pattern, TTDMM and TTDEM have been characterized and used to bind SB and release.…”

“…3,4 Thus, a critical transition for supramolecular structures is seen as a new trend for the development of multiapplications of a single molecule. 5,6 In general, their synthesis has been made either through convergent or divergent approaches. [7][8][9] For a long time, composites of several molecular species with required physicochemical properties have been prepared.…”

“…Thereby, a series of dialkyl malonate esters as branching units with trimesoyl chloride (TMC) have been developed for interacting activities with silibinin (SB) for the development of encapsulation for better transportation. Several scientists have used molecules such as melamine as a core for the synthesis of dendrimers, [5][6][7][8][9] but the TMC, with three binding sites, is now considered as a potential core with a special significance for binding branching molecules. Also, so far, no scientist has used a series of dialkyl malonate esters to act as branchings of the dendrimers with varied entropies caused by oscillations caused by elongation of the alkyl chains.…”