Preparations and properties of tripodal and linear tetradentate N,S-Donor ligands and their complexes containing the MoO22+core

Direct 99mTc Labeling of Pegylated Liposomal Doxorubicin (Doxil) for Pharmacokinetic and Non-Invasive Imaging Studies

“…It contains 2 mg/ml of doxorubicin, 3.19 mg/ml of N-(carbonylmethoxypolyethylene glycol 2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine sodium salt, 9.58 mg/ml of fully hydrogenated soy phosphatidylcholine, and 3.19 mg/ml of cholesterol. BMEDA was synthesized from a modification of the method by Corbin et al (1984), and the chemical structures were verified with 1 H and 13 C NMR.…”

The potential role of intracerebral glutathione in the retention of a representative 99MTc SNS/S mixed ligand complex in mice brain

“…The two (CH3CH2)2NCH2CH2N(CH2CH2SH)2 (L1H2) and p-HSPhCOOCH2CH3 (L2H) ligands are synthesized by modification of reported protocols [6,7]. For the preparation of [99~Tc](LIL 2) complex I a commercial glucoheptonate (GH) kit is reconstituted with [99mTc]NaTcO4 solution and equimolar quantities (< 0.02 retool) of the two ligands are added.…”

Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity

“…Purification was carried out by MPLC yielding S-{2-[(2,4-dioxo-1,2,3,4,-tetrahydropyrimidine-5-yl)amino]-2-oxoe thyl}-D-cysteine 5. The 5-[bis-(2-p-methoxybenzylthioethyl) amine]acetylaminouracil 6 was synthesized by direct condensation of the persilylated 5-(chloroacetyl)aminouracil 2 with bis-(2-p-methoxybenzylthioethyl)amine [9] in acetonitrile followed by column chromatography on silica gel. Scheme 2 shows the structure of some uridine derivatives recently described as potential substrates of herpes simplex virus type-1 thymidine kinase [10].…”