Preparations of<i>C</i>-Nitroso Compounds

The synthesis, spectroscopic characterization and crystal structures of the first 1,4-bis(4-nitrosophenyl)-piperazine (BNPP) (4) bridged dinuclear complexes of rhodium(III) and iridium(III) are presented. All new compounds were characterized by their NMR, IR and mass spectra. The X-ray structure analyses of the obtained half-sandwich complexes revealed a slightly distorted pseudo-octahedral configuration ("three-legged pianostool") for the metal(III) centers. The bridging BNPP ligand is s-N coordinated by both nitroso groups and shows different conformations of the piperazine ring depending on the solvent used for crystallization. Moreover the crystal structures of 1,4-bis(4-nitrosophenyl)piperazine (4) and its precursor 1,4-diphenylpiperazine (3) are reported.

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“…1.37956 (8) 1.81292 (13) 1.80251 (9) 2.01640 (17) 2.2670 (2) 1.55296 (6) m/mm Index range -10 £ h £ 10,…”

Section: Synthesis and Characterization Of The Bnpp Bridged Complexesmentioning

confidence: 99%

1,4-Bis(4-nitrosophenyl)piperazine: novel bridging ligand in dinuclear complexes of rhodium(iii) and iridium(iii)

2012

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“…[47] However, a major problem with C-nitroso compounds is their preparation due to high reactivity of these compounds, particularly with regard to the yield of desired product. [48] Diazeniumdiolates Diazeniumdiolates (NONOates) are the chemical species containing a diolate [N(O)NO] − group to bond to an amine nucleophile adduct. They can be synthesized by exposing the nucleophiles to NO at several atmospheres pressure with protection from aerobic conditions.…”

Section: Biomaterials For 3d Cell Biology Prospective Articlementioning

confidence: 99%

Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

et al. 2017

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Nitric oxide (NO) acts a pivotal role in regulating various physiological processes of vasodilation, platelet aggregation, and vascular smooth muscle cell mitogenesis and proliferation. This makes NO a promising candidate for the treatment of cardiovascular problems like hypertension and vascular stenosis. However, the high reactivity of NO poses an issue for effective NO delivery. To overcome this limitation, recent developments on three-dimensional (3D) materials have been explored with either physical or chemical incorporation of NO releasing donors, to provide spatiotemporal control over NO-signaling pathways in blood vessels. Here, we offer an overview on the current efforts, and propose future perspectives for precise regulation on NO delivery in advanced 3D materials toward proper vascular functionality.

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“…[26] In these experiments, neither the primarily formed nitroso compounds 7 nor their respective dimers could be isolated. [27] The rapid tautomerization of intermediates 7 hereby turned out to be an important feature. Since nitroso compounds can act as efficient radical scavengers to give nitroxides, a longer persistency of 7 could otherwise significantly complicate the overall reaction course.…”

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confidence: 93%