Prepared for PrEP: preferences for HIV pre-exposure prophylaxis among Chinese men who have sex with men in an online national survey

Huang, Wenting; Wu, Dan; Ong, Jason J.; Smith, M. Kumi; Pan, Stephen W.; Yang, Fan; Fu, Hongyun; Tang, Weiming; Tucker, Joseph D.

doi:10.1186/s12879-019-4692-x

Cited by 10 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this cohort that studied oral PrEP preference, uptake, adherence and continuation, nearly half of AGYW preferred oral PrEP to other biomedical prevention methods, but uptake, adherence and PrEP continuation were low. Studies among men who have sex with men (MSM) show that 25–36% prefer oral PrEP to other options, including those in development, that is condoms, LA injectable PrEP and PrEP implants [ 16 , 17 ]. A review of qualitative data from potential PrEP users, including AGYW, highlights that individual “preference” to use oral PrEP depends on how conveniently it can be incorporated into everyday life [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Oral pre‐exposure prophylaxis preference, uptake, adherence and continuation among adolescent girls and young women in Kampala, Uganda: a prospective cohort study

et al. 2022

View full text Add to dashboard Cite

Introduction Oral pre‐exposure prophylaxis (PrEP) has been scaled up; however, data from real‐world settings are limited. We studied oral PrEP preference, uptake, adherence and continuation among adolescent girls and young women (AGYW) vulnerable to HIV in sub‐Saharan Africa. Methods We conducted a prospective cohort study among 14‐ to 24‐year‐old AGYW without HIV who were followed for 12 months in Kampala, Uganda. Within at least 14 days of enrolment, they received two education sessions, including demonstrations on five biomedical interventions that are; available (oral PrEP), will be available soon (long‐acting injectable PrEP and anti‐retroviral vaginal ring) and in development (PrEP implant and HIV vaccine). Information included mode and frequency of delivery, potential side effects and method availability. Volunteers ranked interventions, 1 = most preferred to 5 = least preferred. Oral PrEP was “preferred” if ranked among the top two choices. All were offered oral PrEP, and determinants of uptake assessed using Poisson regression with robust error variance. Adherence was assessed using plasma tenofovir levels and self‐reports. Results Between January and October 2019, 532 volunteers were screened; 285 enrolled of whom 265 received two education sessions. Mean age was 20 years (SD±2.2), 92.8% reported paid sex, 20.4% reported ≥10 sexual partners in the past 3 months, 38.5% used hormonal contraceptives, 26.9% had chlamydia, gonorrhoea and/or active syphilis. Of 265 volunteers, 47.6% preferred oral PrEP. Willingness to take PrEP was 90.2%; however, uptake was 30.6% ( n = 81). Following enrolment, 51.9% started PrEP on day 14 (same day PrEP offered), 20.9% within 30 days and 27.2% after 30 days. PrEP uptake was associated with more sexual partners in the past 3 months: 2–9 partners (aRR = 2.36, 95% CI: 1.20–4.63) and ≥10 partners (aRR 4.70, 95% CI 2.41–9.17); oral PrEP preference (aRR 1.53, 95% CI 1.08–2.19) and being separated (aRR 1.55, 95% CI 1.04–2.33). Of 100 samples from 49 volunteers during follow up, 19 had quantifiable tenofovir levels (>10 μg/L) of which only three were protective (>40 μg/L). Conclusions Half of AGYW preferred oral PrEP, uptake and adherence were low, uptake was associated with sexual behavioural risk and oral PrEP preference. Development of alternative biomedical products should be expedited to meet end‐user preferences and, community delivery promoted during restricted movement.

show abstract

Section: Discussionmentioning

confidence: 99%

Oral pre‐exposure prophylaxis preference, uptake, adherence and continuation among adolescent girls and young women in Kampala, Uganda: a prospective cohort study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This result is inconsistent with some studies reporting that LAI-PrEP is a less preferred modality than other mediations [ 37 – 39 ]. There are also some studies reporting that LAI-PrEP is a less preferred choice [ 19 , 20 , 22 , 27 ]. In addition, a previous study revealed that the availability of LAI-PrEP would increase PrEP interest by 24.5% over oral PrEP alone.…”

Section: Discussionmentioning

confidence: 99%

“…This study also identified significant associations between the number of male sex partners, the HIV serological status of male sex partners, recreational drug use, HSV-2 infection status, and the willingness to take LAI-PrEP among MSM with oral PrEP experience. Previous studies reported on factors associated with MSM’ willingness to take LAI-PrEP or the preference for LAI-PrEP, including demographic (e.g., age [ 22 , 31 , 35 ], ethnicity [ 23 , 33 , 35 , 39 ], educational level [ 21 , 27 , 34 ], income [ 22 ], and insurance [ 39 ]), behavioural (e.g., sex roles [ 20 , 31 ], number of male sexual partners [ 34 , 35 ], HIV serological status of male sex partners [ 21 ], condom use [ 19 ], and HIV testing [ 20 ]), HIV risk perception-related [ 21 , 27 ], and PrEP-related factors (e.g., PrEP use experience [ 22 , 27 , 33 , 35 ]). The factors, such as demographic characteristics and HIV-related behaviours, in this study were similar to those in previous studies.…”

Section: Discussionmentioning

confidence: 99%

Willingness to take long-acting injectable pre-exposure prophylaxis among men who have sex with men who participated in the CROPrEP study: a cross-sectional online study

Liu,

Chu,

Wang

et al. 2023

BMC Public Health

View full text Add to dashboard Cite

Introduction Evidence on the willingness of men who have sex with men (MSM) with oral pre-exposure prophylaxis (PrEP) experience, especially those with suboptimal adherence, to take long-acting injectable PrEP (LAI-PrEP) is critical to guide future LAI-PrEP implementation. Objective The objective was to assess the willingness of MSM with oral PrEP experience to take LAI-PrEP. Methods MSM who participated in the China Real-world Study of Oral PrEP (CROPrEP) were enrolled in this study. Information on the willingness of MSM to take LAI-PrEP and potential correlates was collected using a structured online questionnaire. The main outcomes were the willingness of MSM to take LAI-PrEP and its association with HIV-related behaviours, sexually transmitted infections, and oral PrEP history. Logistic regression was used to identify correlates of the willingness of MSM to take LAI-PrEP. Results A total of 612 former CROPrEP participants (FCPs) were included in this study. There were 315 (51.5%) daily oral PrEP (D-PrEP) users and 297 (48.5%) event-driven oral PrEP (ED-PrEP) users at the last follow-up. Most FCPs (77.8%) were willing to take free LAI-PrEP. FCPs with no less than two sexual male partners (aOR = 1.54, [95% CI: 1.04, 2.29], P = 0.031), those with male partners with unknown HIV statuses (aOR = 2.04, [95% CI: 1.31, 3.18], P = 0.002), those with recreational drug use (aOR = 1.58, [95% CI: 1.05, 2.40], P = 0.030), and those with HSV-2 positivity (aOR = 2.15, [95% CI: 1.30, 3.57], P = 0.003) were more willing to take LAI-PrEP, while ED-PrEP users (aOR = 0.66, [95% CI: 0.45, 0.98], P = 0.037) and FCPs with suboptimal oral PrEP adherence (aOR = 0.58, [95% CI: 0.36, 0.94], P = 0.026) were less willing to take LAI-PrEP. Conclusion LAI-PrEP has good prospects for expanding PrEP coverage. However, FCPs with suboptimal oral PrEP adherence are less likely to take LAI-PrEP. Further intervention and implementation efforts are needed to improve the willingness of MSM to use LAI-PrEP, and sexual health should be considered during the discussion about PrEP initiation.

show abstract

“…Although studies about acceptability from LMIC indicate a preference for long-acting prevention methods generally, these did not specifically consider LA-CAB and its specific logistical considerations for service delivery, which will require more human and financial resources, and will increase costs [39,43,44].…”

Section: Preexposure Prophylaxis Service Delivery Modelsmentioning

confidence: 99%

Long-acting preexposure prophylaxis in low- and middle-income countries: key considerations for implementation

Kaewpoowat

Chariyalertsak

Phanuphak

et al. 2022

Current Opinion in HIV and AIDS

View full text Add to dashboard Cite

Purpose of reviewHIV preexposure prophylaxis (PrEP) is a key tool in ending the HIV epidemic. Long-acting cabotegravir (LA- CAB) phase II/III studies revealed promising efficacy in preventing HIV acquisition. Here, we discuss key considerations for implementing LA-CAB in low- and middle-income countries (LMIC).Recent findingsPrEP roll out in LMIC is still far from ideal, and contextual factors within LMIC vary widely. Implementation science studies are urgently needed to optimize the implementation of LA-CAB in different settings, consider effective service delivery models, and ensure program sustainability. Preferences and concerns regarding LA-CAB among potential users are unknown but likely specific to local context. Demedicalized and simplified PrEP service delivery increases uptake, and ways to safely and effectively do the same for LA- CAB need to be explored. Although ideally LA-CAB should be an additional choice of HIV prevention method, its cost will be the major determinant in deciding its position as a first line choice or restricted second-line option.SummaryLA-CAB has the potential to enhance PrEP uptake. However, several implementation challenges need to be explored and addressed to ensure it can be accessed and utilized in different settings by those who need it the most.

show abstract

Prepared for PrEP: preferences for HIV pre-exposure prophylaxis among Chinese men who have sex with men in an online national survey

Cited by 10 publications

References 31 publications

Oral pre‐exposure prophylaxis preference, uptake, adherence and continuation among adolescent girls and young women in Kampala, Uganda: a prospective cohort study

Oral pre‐exposure prophylaxis preference, uptake, adherence and continuation among adolescent girls and young women in Kampala, Uganda: a prospective cohort study

Willingness to take long-acting injectable pre-exposure prophylaxis among men who have sex with men who participated in the CROPrEP study: a cross-sectional online study

Long-acting preexposure prophylaxis in low- and middle-income countries: key considerations for implementation

Contact Info

Product

Resources

About