Preparing for the Perpetual Challenges of Pandemics of Coronavirus Infections with Special Focus on SARS-CoV-2

Chawla, Sonam; Saxena, Shailendra K.

doi:10.1007/978-981-15-4814-7_14

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reductions in mixing and transmission by social distancing or other related restrictive measures induce a multi-facetted "social cost" (C) [52]. This quantity aggregates over various damages of social distancing on economic and psychological well-being, political stability, or cultural diversity [1,16,53,52,54]. Social cost C of mitigation is here assumed to rise with increasing social distance (denoted as SD), which sums over all differences of contact rates m ij to their values m ij,0 before the epidemic, weighed by m ij,0 and sizes of interacting age classes.…”

Section: Methodsmentioning

confidence: 99%

Decline in mitigation readiness facilitated second waves ofSARS-CoV-2

2021

Preprint

View full text Add to dashboard Cite

Societal responses crucially shape the course of a pandemics but are difficult to predict. Mitigation dynamics is introduced here as an integral part of an epidemiological model, which is applied to the ongoing SARS-CoV-2 pandemic. Unperturbed simulations accurately reproduce diverse epidemic and social response trajectories from 2020 to 2021 reported from 11 European countries, Iran, and 8 US states. High regional variability in the severity and duration of the spring lockdown and in peak mortality rates of the first SARS-CoV-2 wave can be explained by differences in mitigation readiness H which is here mathematically defined as the value of human lives in relation to business-as-usual contact rates. H entails a suite of political, social, and psychological aspects of decision making. The simulations also suggest that a subsequent decrease in H much intensified the second wave and slowed down its decay. With less effective lockdowns, vaccination became the primary mitigation strategy in 2021. Retardation of vaccination relative to a 3-month scheme is projected to provoke an average toll of 1.5 deaths per million and delayed day. This toll particularly rises in regions with high numbers of old and still susceptible people, which is relevant for revising current policies of vaccine distribution.

show abstract

Section: Methodsmentioning

confidence: 99%

Decline in mitigation readiness facilitated second waves ofSARS-CoV-2

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The understanding of COVID-19 and SARS-CoV-2 is at an early stage. Much research is still needed in various areas such as viral transmission, 93 disease progression, differential clinical diagnosis, 94 laboratory diagnosis, 95 antigenic 96 pathogenicity, 97 epitopes, immunogenic kinetics, 98 drugs, immunotherapeutic products, 99 prevention, and control strategies, 100,101 cell-based therapy, 102 phytotherapy, 103 and clinical trials of plasma transfusion. Recently, the potential targets of the immune response to SARS-CoV-2 were predicted by comparison to SARS-CoV.…”

Section: Future Perspectivesmentioning

confidence: 99%

COVID-19: benefits and risks of passive immunotherapeutics

Gupta

Karki

Dandu

et al. 2020

Human Vaccines & Immunotherapeutics

Self Cite

View full text Add to dashboard Cite

Passive immunotherapeutics (PITs), including convalescent plasma, serum, or hyperimmune immunoglobulin, have been of clinical importance during sudden outbreaks since the early twentieth century for the treatment of viral diseases such as severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and swine flu (H1N1). With the recent SARS-CoV-2 pandemic, wherein effective antivirals and vaccines are still lacking, an interest in convalescent plasma therapy as a lifesaving option has resurfaced due to its capacity for antigenic neutralization and reducing viremia. This review summarizes convalescent blood products (CBPs) in terms of current technologies and the shortcomings related to the collection, manufacture, pathogen inactivation, and banking of CBPs, with a specific focus on their plausible applications, benefits, and risks in the COVID-19 pandemic.

show abstract

“…The coronavirus pandemic has promoted isolation and uncertainly fear and panic worldwide. In addition, it will likely lead to changes in political and economic power in ways that can be determined only later [9].…”

Section: Introductionmentioning

confidence: 99%

“…Inhibitory actions of natural antioxidants against coronavirus 9. Oxidative Medicine and Cellular Longevity…”

mentioning

confidence: 99%

Natural Antioxidants: A Review of Studies on Human and Animal Coronavirus

Diniz¹,

Filho

Fielding

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The outbreaks of viruses with wide spread and mortality in the world population have motivated the research for new therapeutic approaches. There are several viruses that cause a biochemical imbalance in the infected cell resulting in oxidative stress. These effects may be associated with the development of pathologies and worsening of symptoms. Therefore, this review is aimed at discussing natural compounds with both antioxidant and antiviral activities, specifically against coronavirus infection, in an attempt to contribute to global researches for discovering effective therapeutic agents in the treatment of coronavirus infection and its severe clinical complications. The contribution of the possible action of these compounds on metabolic modulation associated with antiviral properties, in addition to other mechanisms of action, is presented.

show abstract

Preparing for the Perpetual Challenges of Pandemics of Coronavirus Infections with Special Focus on SARS-CoV-2

Cited by 6 publications

References 25 publications

Decline in mitigation readiness facilitated second waves ofSARS-CoV-2

Decline in mitigation readiness facilitated second waves ofSARS-CoV-2

COVID-19: benefits and risks of passive immunotherapeutics

Natural Antioxidants: A Review of Studies on Human and Animal Coronavirus

Contact Info

Product

Resources

About