Prepulse Modification of the Acoustic Startle Reaction in Healthy Subjects and Patients with Schizophrenia

Сторожева, З. И.; Kirenskaya, A. V.; Lazarev, Ivan E.; Novototskii-Vlasov, V. Yu.; Samylkin, D.; Fastovtsov, G.

doi:10.1007/s11055-011-9545-z

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…In agreement with our previous results (Storozheva et al, 2012) this replication study revealed deficit of PPI in SCH group at LI 60 and 120 ms, which was more prominent at the left eye. Our results contradict the data obtained by other authors who found mainly right-sided PPI impairment in schizophrenia (Braff, Grillon, & Geyer 1992; Filion, Dawson, & Schell, 1993; Hasenkamp et al, 2010; Parwani et al, 2000).…”

Section: Discussionsupporting

confidence: 93%

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Startle Modification and P50 Gating in Schizophrenia Patients and Controls: Russian Population

et al. 2016

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Prepulse modification of the acoustic startle response (ASR) and P50 gating are potential neurophysiological endophenotypes of schizophrenia and may be used in the construction of valid clinical biomarkers. Such approach requires a large amount of data obtained in the representative samples from different gender, socio-typological and ethnic groups, replicating studies using the similar protocols and meta-analyses. This is a replication study of ASR and the first study of P50 suppression in Russian patients with schizophrenia (n = 28) and healthy controls (n = 25). ASR and P50 were estimated according to standard protocols. Patients exhibited increased baseline ASR latency (d = 0.35, p = .026) and reduced prepulse inhibition (PPI) at 60 ms interval (d = 0.39, p = .003) and 120 ms interval (d = 0.37, p = .005) relative to controls. In the P50 test patients displayed greater S2 response amplitude (d = 0.24, p = .036) and deficit of P50 suppression (d = 0.43, p = .001). No correlations of PPI and P50 suppression were found in both groups. Only in controls prepulse ASR facilitation (at 2500 ms interval) positively correlated with P50 suppression (r = -.514, p = .013). In patients PPI displayed significant correlations with Difficulty in abstract thinking (N5: r = -.49, p = .005) and Hallucination (P3: r = .40, p = .036) PANSS scales. Logistic regression showed that the combination of PPI and P50 suppression could serve as a diagnostic predictor. Obtained results demonstrated that both PPI and P50 could be regarded as potential schizophrenia biomarkers in Russian population.

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Section: Discussionsupporting

confidence: 93%

“…In the present study, longer ASR latency was shown to be inherent for Russian patients with schizophrenia. In our previous study (16 healthy and 16 patients with schizophrenia) between-group difference in ASR latency was at the level of a trend (59.4 ± 2.3 ms compared to 65.0 ± 2.4, p = .076) (Storozheva et al, 2012).…”

Section: Discussionmentioning

confidence: 80%

Startle Modification and P50 Gating in Schizophrenia Patients and Controls: Russian Population

et al. 2016

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“…PPF is thought to reflect sustained attention and orienting attention (Conzelmann et al, 2010). Clinical studies have shown less PPF in patients with schizophrenia, compared to healthy controls (e.g.,Kumari et al, 2004; Storozheva et al, 2011; Wynn et al, 2004). Thus, prepulse-induced startle modulation is a promising avenue for translational research.…”

Section: Introductionmentioning

confidence: 99%

The influence of stimulus onset asynchrony, task order, sex and hormonal contraception on prepulse inhibition and prepulse facilitation: Methodological considerations for drug and imaging research

2022

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Background: Prepulse-induced startle modulation occurs when a weak sensory stimulus (‘prepulse’) is presented before a startling sensory stimulus (‘pulse’), producing an inhibited (Prepulse Inhibition, PPI) or facilitated (Prepulse Facilitation, PPF) startle response. We recently identified several gaps and outlined future lines of enquiry to enable a fuller understanding of the neurobiology of PPI and PPF in healthy and clinical populations. However, before embarking on these studies, it is important to consider how task and population characteristics affect these phenomena in healthy humans. Methods: We examined PPI and PPF in separate tasks, with counterbalanced task order across participants in one session, using a range of stimulus onset asynchronies (SOAs), in 48 healthy adults (23 men, 25 women; 10 hormonal contraceptive users) to determine which SOAs produce the strongest PPI and PPF and also explored how sex and hormonal contraception might influence PPI and PPF under these experimental conditions. Results: Both PPI and PPF were affected by SOA, with greatest PPI observed at 60 and 120 ms, and greatest PPF at 4500 and 6000 ms. PPI was influenced by sex (more PPI in men than women) and hormonal contraception, whereas PPF was affected by task order (greater PPF when the PPF task followed, rather than preceded, the PPI task). Conclusions: Our findings indicate that studies of PPI and PPF need to consider, not only sex and hormonal status of study participants, but also task characteristics and presentation order to reduce variance and increase replicability across studies.

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“…We found a negative correlation between muscular %PPI and the HAM-D score for all PP + P intervals at recruitment day only, not at PPI test session day. Several studies investigating the correlation between symptoms’ severity, as measured with scales such as BPRS/PANSS, YMRS and/or Ham-D, and %PPI levels in a wide range of mental illnesses, as Alzheimer [ 98 ], BP [ 33 , 99 ], and SZ [ 56 , 83 , 100 , 101 , 102 , 103 , 104 ], did not find significant associations. A small number of studies observed significant correlations between those measures in SZ patients subgroups or for some of the investigated PP + P intervals, such as the PANSS positive or SAPS being negatively correlated to %PPI60 [ 53 , 105 ] and %PPI120 [ 106 ].…”

Section: Discussionmentioning

confidence: 99%

Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition

et al. 2022

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Background: Altered sensorimotor gating has been demonstrated by Prepulse Inhibition (PPI) tests in patients with psychosis. Recent advances in signal processing methods allow assessment of neural PPI through electroencephalogram (EEG) recording during acoustic startle response measures (classic muscular PPI). Simultaneous measurements of muscular (eye-blink) and neural gating phenomena during PPI test may help to better understand sensorial processing dysfunctions in psychosis. In this study, we aimed to assess simultaneously muscular and neural PPI in early bipolar disorder and schizophrenia patients. Method: Participants were recruited from a population-based case-control study of first episode psychosis. PPI was measured using electromyography (EMG) and EEG in pulse alone and prepulse + pulse with intervals of 30, 60, and 120 ms in early bipolar disorder (n = 18) and schizophrenia (n = 11) patients. As control group, 15 socio-economically matched healthy subjects were recruited. All subjects were evaluated with Rating Scale, Hamilton Rating Scale for Depression, and Young Mania Rating Scale questionnaires at recruitment and just before PPI test. Wilcoxon ranked sum tests were used to compare PPI test results between groups. Results: In comparison to healthy participants, neural PPI was significantly reduced in PPI 30 and PPI60 among bipolar and schizophrenia patients, while muscular PPI was reduced in PPI60 and PPI120 intervals only among patients with schizophrenia. Conclusion: The combination of muscular and neural PPI evaluations suggested distinct impairment patterns among schizophrenia and bipolar disorder patients. Simultaneous recording may contribute with novel information in sensory gating investigations.

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Prepulse Modification of the Acoustic Startle Reaction in Healthy Subjects and Patients with Schizophrenia

Cited by 5 publications

References 14 publications

Startle Modification and P50 Gating in Schizophrenia Patients and Controls: Russian Population

Startle Modification and P50 Gating in Schizophrenia Patients and Controls: Russian Population

The influence of stimulus onset asynchrony, task order, sex and hormonal contraception on prepulse inhibition and prepulse facilitation: Methodological considerations for drug and imaging research

Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition

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