PRESAGE® as a solid 3-D radiation dosimeter: A review article

Khezerloo, Davood; Nedaie, Hassan Ali; Takavar, Abbas; Zirak, Alireza; Farhood, Bagher; Movahedinejhad, Hadi; Banaee, Nooshin; Ahmadalidokht, Isa; Knuap, Courtney

doi:10.1016/j.radphyschem.2017.06.002

Cited by 44 publications

(21 citation statements)

References 65 publications

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“…Various studies have analyzed the MRI response of polymer gels for possible application in radiotherapy dose mapping ([ 58 , 63 ] and references therein). In particular, polymer gels have been investigated for dosimetry in conformal therapy, IMRT, IMAT, IGRT, VMAT and tomotherapy [ 55 , 70 , 83 , 88 , 102 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], small photon fields [ 136 , 137 , 138 ], stereotactic radiosurgery [ 55 , 139 , 140 , 141 , 142 ], 60-cobalt source [ 143 , 144 ], brachytherapy [ 55 , 85 , 92 , 145 , ...…”

Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

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Section: Polyacrylamide Gelsmentioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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“…The high conformity of the prescribed dose with the planning target volume (PTV) can effectively kill cancerous cells while preserving the surrounding healthy tissue. [ 5 6 7 ]…”

Section: Challenges In Small-field Dosimetrymentioning

confidence: 99%

“…[ 81 ] These detectors are divided into three categories: Fricke, polymer, and radiochromic gels. [ 6 ] Fricke gels are highly reproducible and easy to prepare than other gel dosimeters, but diffusion in the gel is a disadvantage. [ 82 83 ] Polymer gels are high-sensitivity dosimeters without any diffusion issues; however, fabrication of these detectors is difficult due to their sensitivity to the presence of oxygen.…”

Section: Various Dosimeters Used In Small-field Dosimetrymentioning

confidence: 99%

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Different dosimeters/detectors used in small-field dosimetry: Pros and cons

et al. 2018

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With the advent of complex and precise radiation therapy techniques, the use of relatively small fields is needed. Using such field sizes can cause uncertainty in dosimetry; therefore, special attention is required both in dose calculations and measurements. There are several challenges in small-field dosimetry such as the steep gradient of the radiation field, volume averaging effect, lack of charged particle equilibrium, partial occlusion of radiation source, beam alignment, and unable to use a reference dosimeter. Due to these challenges, special dosimeters are needed for small-field dosimetry, and this review article discusses this topic.

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“…Among various other dosimeters such as polymer and Fricke gels, required for 3D dosimetry, PRESAGE® (Heuris Pharma LLC, Skillman, NJ, USA) due to its dosimteric and physical properties is chosen in 3D dosimetry to give volumetric dose information. 1 PRESAGE is a radiochromic 3D dosimeter that was first fabricated in 2006. 2 It is basically a plastic material which is composed of leuco dye and an optically clear, solid polyurethane matrix with free radical initiators.…”

Section: Introductionmentioning

confidence: 99%

Review on the feasibility of using PRESAGE® dosimeter in various radiotherapy techniques

et al. 2020

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The emergence of advanced radiotherapy techniques, such as intensity-modulated radiotherapy (IMRT), brachytherapy, conformal radiotherapy, magnetic resonance-guided radiotherapy (MRgRT), stereotactic synchrotron radiotherapy (SSRT) and microbeam radiotherapy (MRT), has increased the importance of the verification of volumetric dose distribution. The verification of dose distribution is usually done by 2D films and 3D gel dosimeters, but PRESAGE® due to its affordability, reproducibility, precision, accuracy, unique dosimetric and physical properties is considered as an effective candidate in providing 3D dose data. PRESAGE® is insensitive to oxygen contamination, machinable and can be molded to a variety of shapes and sizes. It is absorbing rather than scattering light which facilitates high-accuracy readout by optical computed tomography (OP-CT). This review focuses on the feasibility of using PRESAGE® in various complicated radiotherapy techniques by comparing its measured doses with 2D films and treatment planning system (TPS) calculated doses.

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PRESAGE® as a solid 3-D radiation dosimeter: A review article

Cited by 44 publications

References 65 publications

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Different dosimeters/detectors used in small-field dosimetry: Pros and cons

Review on the feasibility of using PRESAGE® dosimeter in various radiotherapy techniques

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