Presbyopic PiXL Cross-Linking

Kanellopoulos, Anastasios John; Asimellis, George

doi:10.1007/s40135-014-0060-6

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…Moreover, we also consulted other literature to find the parameter values of normal and diseased mice, as the reference indexes in our work [37–39]. The reference values of the human eye listed in Table 3 were found in the studies of measuring eye structure in OCT images [40–42]. Observing these data, it can be concluded that, compared with the uncorrected images, the corrected data are reasonable and closer to the reference value, verifying the effectiveness of our proposed correction algorithms.…”

Section: Resultssupporting

confidence: 55%

Correction of refractive distortion in whole‐eye optical coherence tomography imaging of the mouse eye

Tan

Qiu

Ding

et al. 2022

Journal of Biophotonics

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Optical coherence tomography (OCT) is an imaging modality that acquires high‐resolution cross‐sectional images of living tissues and it has become the standard in ophthalmological diagnoses. However, most quantitative morphological measurements are based on the raw OCT images which are distorted by several mechanisms such as the refraction of probe light in the sample and the scan geometries and thus the analysis of the raw OCT images inevitably induced calculation errors. In this paper, based on Fermat's principle and the concept of inverse light tracing, image distortions due to refraction occurred at tissue boundaries in the whole‐eye OCT imaging of mouse by telecentric scanning were corrected. Specially, the mathematical correction models were deducted for each interface, and the high‐precision whole‐eye image was recovered segment by segment. We conducted phantom and in vivo experiments on mouse and human eyes to verify the distortion correction algorithm, and several parameters of the radius of curvature, thickness of tissues and error, were calculated to quantitatively evaluate the images. Experimental results demonstrated that the method can provide accurate and reliable measurements of whole‐eye parameters and thus be a valuable tool for the research and clinical diagnosis.

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Section: Resultssupporting

confidence: 55%

Correction of refractive distortion in whole‐eye optical coherence tomography imaging of the mouse eye

Tan

Qiu

Ding

et al. 2022

Journal of Biophotonics

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“… 7 , 22 , 26 – 29 Corneal approaches using an excimer laser include monovision, modification of corneal asphericity, and methods inducing corneal multifocality. 2 , 3 , 30 – 36 …”

Section: Discussionmentioning

confidence: 99%

“…CXL was implemented in a specific, annular section mid-peripherally, employing differential response and biomechanical change, inducing central corneal steepening and asphericity changes. 2 , 3 …”

Section: Discussionmentioning

confidence: 99%

Femtosecond laser-assisted in situ keratomileusis multifocal ablation profile using a mini-monovision approach for presbyopic patients with hyperopia

Vastardis¹,

Pajic-Eggspühler²,

Müller

et al. 2016

OPTH

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PurposeTo report the visual outcomes of the femtosecond laser-assisted multifocal aspheric corneal ablation profile using a mini-monovision approach and to evaluate if corneal multifocality was effective, and to report the relative benefits of this approach.Patients and methodsBilateral femtosecond laser-assisted in situ keratomileusis using a multifocal aspheric corneal ablation profile was performed on 19 hyperopic patients (38 eyes). They were divided into two groups based on eye dominance: dominant eye (DE) group targeting emmetropia and the nondominant eye (NDE) group targeting −0.5 D slight myopia. The uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), and retreatment rates were reported from baseline to 6 months.ResultsThe UNVA, UIVA, and UDVA improved significantly in both groups (Kruskal–Wallis test, DE and NDE: P<0.00001, P<0.000005, and P=0.00001, respectively). Corrected distance visual acuity (CDVA) baseline was better in both groups in comparison to UDVA at 6 months (Wilcoxon test, DE: P<0.001, 95% confidence interval (CI) of the median 0.0–0.0 LogMAR and 0.1000–0.1218 LogMAR and NDE: P=0.010, 95% CI of the median 0.0–0.0 LogMAR and 0.00–0.10 LogMAR). There was a significant loss of lines between CDVA baseline and UDVA at 6 months in both groups (DE group: 68% of eyes lost one line or more; NDE group: 58% of eyes lost one line or more). The corrected near visual acuity baseline compared to UNVA at 6 months was not statistically important (Wilcoxon test, DE: P=0.8125, 95% CI of the median 0.0–0.0 LogMAR and 0.0–0.0 LogMAR and NDE: P=0.82, 95% CI of the median 0.0–0.0 LogMAR and 0.0–0.0 LogMAR). The comparison among the UDVA, UIVA, and UNVA between the two groups at baseline and during all follow-ups was not statistically important. Two cases from the DE group were retreated (6%).ConclusionUse of this multifocal aspheric corneal ablation profile in patients with hyperopic presbyopia significantly improved UDVA, UIVA, and UNVA. This improvement was due to created multifocality of the cornea. The mini-monovision seems not to affect UDVA, UIVA, and UNVA between the two groups. The retreatment rates at the 6-month evaluation were significantly less in our study when compared with other studies. This method seems to improve UDVA, UIVA, and UNVA but could result in a significant statistical difference between CDVA baseline and UDVA at 6 months that leads to loss of lines in distance vision. Despite promising results, this is a preliminary evaluation of this new profile, and a larger number of eyes are needed to verify visual outcomes, retreatment rates, and safety.

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