Prescription Pattern and Drug Utilization Analysis in Patients with Acute Coronary Syndrome

Abstract

Background: Acute Coronary Syndrome (ACS) is one of the major causes of morbidity and mortality in developing countries, which illustrates the need for rational prescribing of drugs to the patients. Aim: The aim of the study is to analyse the prescription pattern and drug utilisation for the drugs prescribed to the patients with ACS by checking the compliance with the standard guidelines provided by the American College of Cardiology/American Heart Association (ACC/AHA). Materials and Methods: A prospective observational study for a period of 6 months was conducted in the cardiology and cardiothoracic departments of a tertiary care hospital. The sample size was determined by using Rao software and percentage of the data was calculated using Microsoft Excel 2007. Results: A total of 270 patients were enrolled in the study in which males (219) dominated females (51) and were found in the age group of 60-69 years (92). Diabetes (62.9%) followed by hypertension (54.8%) were found to be the dominant risk factors. The prescribing frequency of dual antiplatelet therapy, statins, beta blockers, angiotensin converting enzyme inhibitors/angiotensin receptor blockers and nitrates was 93.3%, 97.3%, 94.1%, 76.3% / 14.1% and 41.2%. The treatment given to the patients was not completely in compliance with the ACC/ AHA guidelines (18.14%). Conclusion: The study provides an overall insight of the pattern of drugs prescribed to the patients with ACS which reveals the necessity of improving the rational prescribing of drugs in accordance with the standard guidelines.

Antiplatelet Agents Utilization Pattern and Assessment of Patient Specific Drug use Problems among Cardiac Patient

“…Hyperlipidemia is a key risk factor for coronary heart disease. [2] In our study total medication prescribed was 494, the highest number of drugs prescribed was 5-8(56%), followed by 1-5 (32.7%). The least number of patients were prescribed >8(11.3%) drugs.…”

“…In India ratio of mortality increased by 59% from 23.2 million (1990) to 37 million (2010). [1] CVD, acute coronary syndrome is considered one of the leading causes of mortality and morbidity worldwide [2]. Acute coronary syndrome is consisting of ST-Elevation Myocardial Infarction, Non-ST Elevation Myocardial Infraction, Or Unstable Angina [3].…”

A Prospective Cross-Sectional Study of Acute Coronary Syndrome Patients’ Quality of Life and Drug Prescription Patterns at Riyadh Region Hospitals, Saudi Arabia

“…Moreover, the American Heart Association’s (AHA) 2023 Heart-Disease and Stroke Statistics Update documented that about 15.5 million people in the United States were diagnosed with IHD, and the related cost was 207 billion dollars [ 4 ]. Furthermore, between 2013 and 2030, this cost is anticipated to climb by 43% [ 5 ]. In Saudi Arabia, IHD has a substantial economic burden (10,710 dollars per patient) and has been the top cause of death from 2000 to 2012, with a mortality rate of 21.7% in 2012 [ 6 ].…”

“…While CAD can be asymptomatic, ACS is characterized by signs and symptoms of abrupt myocardial ischemia in the presence of stable CAD. CAD is caused by atherosclerosis in the coronary arteries, in which atherosclerotic plaque builds up inside the coronary arteries, restricting blood flow and, thereby, oxygen delivery to the heart [ 5 , 9 ]. In addition, ACS is a major cause of the global burden of CVS, contributing to 18 million deaths in 2016, and an estimated 23 million people will die by 2030.…”

“…HRQOL measurements evaluate a patient’s experience with health problems in areas such as physical, emotional, and social functioning, performance role, pain, and tiredness. A poor HRQOL score can have an impact on the process of recovery, decrease treatment adherence, diminish the capacity to conduct activities of daily living, raise hospital readmission rates, and place the patient at risk for complications and mortality [ 5 , 11 ].…”