Prescription patterns of herbal medicine for menopausal disorders in major Korean medicine hospitals: A multicenter retrospective study

Lee, Hye Won; Choi, Tae‐Young; Lee, Myeong Soo; Lee, Ju Ah; Jun, Ji Hee; Choi, Jiae; Ang, Lin; Lee, Chang‐Hoon; J, Lee; Park, Kyoung Sun; Kim, Dong Chul; Jang, Se-Ran; Yoo, Jeong-Eun; Kim, Dong-Il; Cho, Seonghee; Yang, SeungJeong; Lee, In Seon; Ahn, In-Suk; Lee, Dong-Nyung; Lee, Jang Ho; Song, Mi-Young; Kim, Eunseop

doi:10.1016/j.imr.2020.100706

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Herbal medicine (HM) is widely used for women’s healthcare [ 6 , 7 , 8 , 9 , 10 , 11 ]. Korean medicine (KM) is the conventional medicine used in South Korea, and most treatments are covered by the national health insurance system.…”

Section: Introductionmentioning

confidence: 99%

Development of the Korean Medicine Core Outcome Set for Primary Dysmenorrhea (COS-PD-KM) for Herbal Medicine Treatment of Primary Dysmenorrhea in Primary Clinics

Kim

et al. 2022

IJERPH

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The aim of this study was to develop a Korean medicine (KM) core outcome set (COS) for primary dysmenorrhea to evaluate the effectiveness of herbal medicine (HM) in treating primary dysmenorrhea in patients visiting KM primary clinics. Previously reported outcomes were identified through a literature review to define outcomes and effect modifiers (EMs) for the questionnaire. Experts were invited to conduct modified Delphi consensus exercises, and primary care clinicians were invited to conduct Delphi consensus exercises to evaluate suitability and feasibility. Finally, an additional round of a modified Delphi exercise was conducted with experts to obtain a final agreement on the COS. Seventeen outcomes and 15 EMs were included from a literature review, and one effect modifier was suggested by the experts (Phase 1). In Phase 2, after the modified Delphi consensus exercises by experts, 10 outcomes and 11 EMs were included in the COS. The clinicians all agreed on the feasibility of COS (Phase 3). Finally, 10 outcomes and 6 EMs were included in the COS-PD-KM after the final modified Delphi consensus exercise (Phase 4). The effectiveness of HM used in primary clinics could be evaluated with this COS in patients with primary dysmenorrhea. Further studies that involve more relevant stakeholder groups, such as patient representatives and gynecological experts, are needed.

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Section: Introductionmentioning

confidence: 99%

Development of the Korean Medicine Core Outcome Set for Primary Dysmenorrhea (COS-PD-KM) for Herbal Medicine Treatment of Primary Dysmenorrhea in Primary Clinics

Kim

et al. 2022

IJERPH

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“…Xiaoyao-san (XYS; also called Soyo-san in traditional Korean medicine and Shoyo-san in Kampo medicine) is a traditional herbal formula composed of eight botanical drugs: Glycyrrhizae radix et rhizoma , Angelicae sinensis radix , Poria cocos , Paeoniae radix alba , Atractylodis macrocephalae rhizoma , Bupleuri radix , Menthae herba , and Zingiberis rhizoma recens ( Qin et al, 2009 ). XYS is one of the representative prescriptions traditionally used for gynecological diseases such as menopausal symptoms ( Chen et al, 2011 ; Lee et al, 2021 ). Some laboratory studies have demonstrated estrogen- ( Hu et al, 2022 ) and antidepressant-like effects of XYS ( Dai et al, 2010 ; Yuan et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of Xiaoyao-san for the treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials

et al. 2023

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Objective: Although Xiaoyao-san (XYS) is a popular herbal remedy for indigestion, there is insufficient evidence to recommend it as a treatment option for functional dyspepsia (FD). This review aimed to assess the safety and efficacy of XYS in patients with FD, compared to conventional Western medicine (WM).Methods: Two independent reviewers searched for randomized controlled trials (RCTs) using 11 electronic databases, including Medline and Embase, to evaluate therapeutic effects of XYS on FD up to 31 January 2023. The primary outcome was the total clinical efficacy rate (TCE), and secondary outcomes included scores of dyspepsia-related symptoms (DSS) and incidence of adverse events (AEs). The risk of bias was evaluated using the Cochrane collaboration tool, and data synthesis and subgroup analyses were performed using the Review Manager program.Results: Six studies involving 707 participants were included in the meta-analysis. XYS significantly improved TCE compared to WM (RR = 1.15, 95% CI: 1.05, 1.26, p = 0.002) with high heterogeneity (I2 = 59%, p = 0.06). Combination therapy also showed higher TCE than WM alone (RR = 1.22, 95% CI: 1.05, 1.41, p = 0.008), and the heterogeneity was low (I2 = 0%, p = 0.86). The results showed a greater reduction in DSS in the XYS and combination therapy groups than in the WM alone group (SMD = −0.72, 95% CI: −0.90, −0.53, p < 0.00001) with low heterogeneity (I2 = 44%, p = 0.15), especially for abdominal distension and upper abdominal pain. AEs occurred less frequently in the XYS and combination therapy groups than in the WM alone group (RR = 0.20, 95% CI: 0.07, 0.63, p = 0.006), and the heterogeneity was low (I2 = 45%, p = 0.18). The certainty of the evidence for each outcome was rated from “very low” to “high.”Conclusion: This review suggests that XYS is effective and safe for reducing complaints in patients with FD. However, high-quality RCTs should be conducted to establish more convincing therapeutic evidence of XYS for the treatment of FD.Systematic Review Registration:https://www.crd.york.ac.uk/prospero, CRD42020178842

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“…Ekstrak MeOH rimpang kunir putih menunjukkan efek sitotoksik terhadap sel AGS kanker lambung menggunakan uji viabilitas sel MTT. Senyawa Kurkumenol, 4,8-dioxo-6β-methoxy-7α,11-epoxycarabrane dan zedoarofuran diidentifikasi sebagai komponen sitotoksik utama dalam rimpang kunir putih(55). Dalam penelitian lain juga melaporkan bahwa minyak atsiri yang diperoleh dari kunir putih memiliki efek sitotoksik yang efisien pada sel karsinoma paru non-sel kecil (NSCLC) dan menyebabkan apoptosis sel.…”

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Kunir Putih (Curcuma zedoaria Rocs.): Formulasi, Kandungan Kimia dan Aktivitas Biologi

2022

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AbstrakKunir putih (Curcuma zedoaria Rosc.) adalah tanaman herbal yang memiliki populasi cukup banyak di Indonesia. Kunir putih telah lama digunakan karena berdasarkan data empiris memiliki aktivitas sebagai antioksidan, anti bakteri, anti inflamasi dan anti kanker. Hal ini mengindikasikan kunir putih (Curcuma zedoaria Rosc.) memiliki bahan aktif atau metabolit sekunder seperti curcuminol yang memberikan aktivitas tersebut. Penggunaan kunir putih pada kalangan masyarakat terbatas pada obat herbal dan jamu dengan pengolahan standar sehingga saat ini banyak dikembangakan ulasan mengenai formulasi dan inovasi dari kunir putih sehingga lebih memberikan aktivitas terapi. Pada review artikel ini akan diulas secara lengkap mengenai kunir putih dalam hal formulasi yang telah dikembangkan, kandungan kimia dan aktivitas biologi yang telah teruji pada kunir putih. Kata kunci: Aktivitas biologi, Formulasi, Kunir putih

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Prescription patterns of herbal medicine for menopausal disorders in major Korean medicine hospitals: A multicenter retrospective study

Cited by 7 publications

References 20 publications

Development of the Korean Medicine Core Outcome Set for Primary Dysmenorrhea (COS-PD-KM) for Herbal Medicine Treatment of Primary Dysmenorrhea in Primary Clinics

Development of the Korean Medicine Core Outcome Set for Primary Dysmenorrhea (COS-PD-KM) for Herbal Medicine Treatment of Primary Dysmenorrhea in Primary Clinics

Safety and efficacy of Xiaoyao-san for the treatment of functional dyspepsia: a systematic review and meta-analysis of randomized controlled trials

Kunir Putih (Curcuma zedoaria Rocs.): Formulasi, Kandungan Kimia dan Aktivitas Biologi

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