Presence of prostaglandin E in lung tumors from normocalcemic patients

Kukreja, Subhash C.; Shemerdiak, Walter P.; York, Patricia A. J.; Lad, Thomas E.; Abramson, Edith C.; Thomas, Paul; Mir, Juan

doi:10.1016/0002-9343(82)90538-1

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…Of the 6140 unique articles that were identified based on the literature search strategy, 213 articles were included for full-text review. A total of 53 studies were included in the systematic literature review, of which, 27 studies were categorical studies [ 42 , 43 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ], 24 studies were concentration studies [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 39 , 40 , 41 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 ,…”

Section: Resultsmentioning

confidence: 99%

“…Included studies were published between 1982 and 2019 ( Table 1 ). Thirty-eight studies enrolled participants from both men and women [ 25 , 26 , 27 , 28 , 29 , 33 , 34 , 35 , 36 , 42 , 43 , 48 , 49 , 53 , 54 , 55 , 56 , 60 , 61 , 62 , 64 , 65 , 67 , 68 , 69 , 70 , 71 , 73 , 74 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 ], three studies included only female participants [ 50 , 51 , 72 ], and ten studies included only male participants [ 30 , 39 , 41 , 52 , 57 , 58 , 59 , 63 , ...…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies included active smokers exclusively [ 41 , 57 , 58 , 59 , 66 , 67 , 76 , 83 ] and three studies only included participants who had never been smokers [ 63 , 72 , 77 ]. Nine studies did not report the smoking status of their participants [ 26 , 30 , 31 , 33 , 39 , 40 , 73 , 74 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

“…For self-controlled case-control studies (4 studies) [ 33 , 39 , 40 , 41 ], we used a modified version of the NOS by excluding the question on the definition of controls, as the criterion was not relevant to the studies. The overall quality scores for these studies were then scaled to a maximum score of nine points, in order to facilitate comparison across all studies.…”

Section: Methodsmentioning

confidence: 99%

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Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies

et al. 2020

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Globally, lung cancer is the most prevalent cancer type. However, screening and early detection is challenging. Previous studies have identified metabolites as promising lung cancer biomarkers. This systematic literature review and meta-analysis aimed to identify metabolites associated with lung cancer risk in observational studies. The literature search was performed in PubMed and EMBASE databases, up to 31 December 2019, for observational studies on the association between metabolites and lung cancer risk. Heterogeneity was assessed using the I2 statistic and Cochran’s Q test. Meta-analyses were performed using either a fixed-effects or random-effects model, depending on study heterogeneity. Fifty-three studies with 297 metabolites were included. Most identified metabolites (252 metabolites) were reported in individual studies. Meta-analyses were conducted on 45 metabolites. Five metabolites (cotinine, creatinine riboside, N-acetylneuraminic acid, proline and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene) and five metabolite groups (total 3-hydroxycotinine, total cotinine, total nicotine, total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (sum of concentrations of the metabolite and its glucuronides), and total nicotine equivalent (sum of total 3-hydroxycotinine, total cotinine and total nicotine)) were associated with higher lung cancer risk, while three others (folate, methionine and tryptophan) were associated with lower lung cancer risk. Significant heterogeneity was detected across most studies. These significant metabolites should be further evaluated as potential biomarkers for lung cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies

et al. 2020

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“…The potent inhibitory effect of calcitonin seen in our studies suggests that increased osteoclastic activity underlies the resorptive effects of the factor, although the synthesis of prostaglandins and, possibly, ofa prostaglandin-dependent regulator of osteoclast activity might occur in adjacent osteoblasts in the calvarial tissue (37). The increased release of prostaglandins by bone in response to this or similar factors secreted by tumors in patients with humoral hypercalcemia could account for the elevated levels of plasma prostaglandins often seen in such patients ( 13), the occasional response of humoral hypercalcemia to indomethacin or aspirin (1,11,13), and the observation that tumor prostaglandin content often correlates poorly with hypercalcemia (38). The involvement of prostaglandins in the resorptive response of mouse calvaria to TCC factor is analogous to the effects of some bone-resorbing growth factors, including EGF and plateletderived growth factor, in this tissue (32,39).…”

Section: Discussionmentioning

confidence: 99%

Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells.

Bringhurst¹,

Bierer²,

Godeau³

et al. 1986

J. Clin. Invest.

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Secretion by tumor cells of circulating bone-resorbing factors may frequently underlie the hypercalcemia that occurs in patients with malignancy. Efforts to identify the responsible mediators have been hampered by a lack of available human tumor cell systems suitable for study of the pathogenesis of the humoral hypercalcemia syndrome. We have established a transitionalcell carcinoma (TCC) line in vitro from a patient with humoral hypercalcemia. These cells are tumorigenic and cause hypercalcemia in athymic nude mice. Culture medium conditioned by TCC cells contains potent bone-resorbing activity in vitro, the physical and biological properties of which are similar to those of bone-resorbing activity present in the original patient's urine. The bone-resorbing activity of the TCC factor is accompanied by increased prostaglandin release from bone and is blocked by indomethacin and calcitonin. The TCC-derived bone-resorbing activity coelutes with prostaglandin-stimulating activity during gel filtration with an approximate molecular weight of 15,000. This activity is nondialyzable, stable to concentrated urea and reducing agents, and destroyed by boiling. The TCC factor does not increase cyclic AMP production in bone or kidney bioassays and does not exhibit transforming growth factor activity. We conclude that a unique macromolecular factor released by TCC cells causes bone resorption by a mechanism dependent upon stimulation of bone cell cyclooxygenase, and that this factor is the probable cause of the hypercalcemia in vivo. The TCC cell line provides a new model for study of the human humoral hypercalcemia syndrome.

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Inflammation and Lung Cancer: Eicosanoids

Nemenoff

Gijón

2015

Inflammation and Lung Cancer

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Presence of prostaglandin E in lung tumors from normocalcemic patients

Cited by 5 publications

References 15 publications

Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies

Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies

Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells.

Inflammation and Lung Cancer: Eicosanoids

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