Presenile diffuse familial sebaceous hyperplasia successfully treated with low‐dose isotretinoin: A report of two cases and review of the published work

Abstract

Presenile diffuse familial sebaceous hyperplasia (PDFSH) presents as extensive yellowish papules with central umbilication on the face without involvement of periorificial regions and occurs in adolescents or young adults with a positive family history. Thirteen cases of PDFSH have been reported in the English‐language published work, 10 of which responded to oral isotretinoin from 0.5 to 1 mg/kg per day but recurrences were often observed. Herein, we report two cases of PDFSH, which were successfully managed without recurrence with prolonged low‐dose isotretinoin (0.2 mg/kg per day, a cumulative dose of 41 and 64 mg/kg, respectively). Treatment protocols among different published works were reviewed to verify the efficacy of isotretinoin.

Uses of Isotretinoin Other Than Acne: Traditional Review

“…Ancak nüks sıktır. 20 ■ Siklosporin ile indüklenen sebase hiperplazi: Sebase hiperplazi, transplant alıcılarında kullanılan siklosporin ve takrolimusun bilinen bir yan etkisidir. Siklosporin ve takrolimus, lipidde yüksek oranda çözünürler ve deride birikerek sebase hiperplaziye neden olurlar.…”

Case of presenile diffuse sebaceous hyperplasia treated with adapalene gel

“…Sebaceous hyperplasia can also occur in hypohidrotic ectodermal dysplasia or Muir-Torre syndrome. 3 However, he was unlikely to have those as he had no family history. Regardless of the pathological background, oral isotretinoin often follows a good course; however, lesions relapsed after discontinuation of therapy.…”

“…Regardless of the pathological background, oral isotretinoin often follows a good course; however, lesions relapsed after discontinuation of therapy. 1,3 Additionally, there have been a few reports of diffuse sebaceous hyperplasia treated with topical tretinoin cream. [2][3][4] Tretinoin cream is not approved in Japan, so adapalene gel was used in anticipation of…”

“…1,3 Additionally, there have been a few reports of diffuse sebaceous hyperplasia treated with topical tretinoin cream. [2][3][4] Tretinoin cream is not approved in Japan, so adapalene gel was used in anticipation of…”