Present Status of Injectable Contraceptives: Results of Seven-Years Study

Tyler, Edward T.; Levin, Marvin P.; Elliot, Julia; Dolman, Helen

doi:10.1016/s0015-0282(16)37562-8

Cited by 37 publications

(3 citation statements)

References 14 publications

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“…Though not comparable with our own material, certain studies on the resumption of ovulation, that is, of potential fertility, should be mentioned. Tyler, Levin, Elliot & Dolman (1970) found that virtually all of twenty-seven patients ovulated within 1 year of the last injection. Lee (1969) had two patients who withdrew from the study after a single injection of DMPA and became pregnant in 7 and 8 months respectively.…”

Section: Return Of Fertilitymentioning

confidence: 98%

Return of menstruation and fertility in Thai women after contraceptive injections

McDaniel

Pardthaisong

1971

J. Biosoc. Sci.

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A study was made of the return of spontaneous menstruation and fertility in 121 Thai women who had received contraceptive injections of medroxyprogesterone acetate (DMPA) at intervals of 3 or 6 months with supplements of oral oestrogen at monthly intervals and who, for various reasons, had discontinued medication after 6 months or more.Spontanecous menstruation returned in 113 of the women within 6 months, but no direct relation was found between the number of injections, period of usage or total dose of DMPA and the time required for the return of menstruation.Of the 121 women who discontinued medication, only seventeen stated that they did so because they wished to conceive. Of these, twelve became pregnant within 10 months and three more within 27 months. The 104 women who discontinued medication for other reasons had a much lower pregnancy rate and must be supposed to have used, at least to some extent, other methods of contraception.

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Section: Return Of Fertilitymentioning

confidence: 98%

Return of menstruation and fertility in Thai women after contraceptive injections

McDaniel

Pardthaisong

1971

J. Biosoc. Sci.

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“…Progestins have potent effects on the endometrium and their use is associated with breakthrough bleeding 43 , altered expression of basement membrane components, endometrial atrophy 44 , decreased number and size of epithelial glands, decreased stromal thickness, altered cytokeratin expression 45 , and decreased height of columnar epithelial cells 46 . Our demonstration that MPA slows wound closure by endometrial epithelial cells is consistent with those of previous studies that reported MPA inhibits migration of the Ishikawa endometrial epithelial cell line following injury via blockade of RANK/RANKL signaling, decreased vimentin expression, decreased IL-6 and TGFβ, and altered epithelial-mesenchymal transition 47,48 .…”

Section: Discussionmentioning

confidence: 99%

Medroxyprogesterone acetate inhibits wound closure of human endometrial epithelial cells and stromal fibroblasts in vitro

Patel

Rodriguez-García

Shen

et al. 2021

Sci Rep

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Mucosal integrity in the endometrium is essential for immune protection. Since breaches or injury to the epithelial barrier exposes underlying tissue and is hypothesized to increase infection risk, we determined whether endogenous progesterone or three exogenous progestins (medroxyprogesterone acetate (MPA), norethindrone (NET), and levonorgestrel (LNG)) used by women as contraceptives interfere with wound closure of endometrial epithelial cells and fibroblasts in vitro. Progesterone and LNG had no inhibitory effect on wound closure by either epithelial cells or fibroblasts. MPA significantly impaired wound closure in both cell types and delayed the reestablishment of transepithelial resistance by epithelial cells. In contrast to MPA, NET selectively decreased wound closure by stromal fibroblasts but not epithelial cells. Following epithelial injury, MPA but not LNG or NET, blocked the injury-induced upregulation of HBD2, a broad-spectrum antimicrobial implicated in wound healing, but had no effect on the secretion of RANTES, CCL20 and SDF-1α. This study demonstrates that, unlike progesterone and LNG, MPA and NET may interfere with wound closure following injury in the endometrium, potentially conferring a higher risk of pathogen transmission. Our findings highlight the importance of evaluating progestins for their impact on wound repair at mucosal surfaces.

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“…Aunque algunos investigadores han mostrado que la AMPO aumenta las concentraciones de glucosa en sangre (3,12,35), no existe un acuerdo general a este respecto (31,38,39,41 ). El análisis de este aspecto no mostró diferencias significantes en las glicemias basal y post-prandial antes y después del tratamiento.…”

Section: Ooorunclassified

Manejo de la hiperplasia endometrial con acetato de medroxiprogesterona de depósito

Escallón¹,

Roa²,

Arismendi³

et al. 1991

Rev. Colomb. Obstet. Ginecol.

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Un total de 41 pacientes con diagnóstico histológico de Hiperplasia Endometrial, fueron sometidas a tratamiento médico con Acetato de Medroxiprogesterona de Depósito (AMPD). Un grupo de 26 pacientes (Grupo I), recibió una dosis de 2.5 mgr/Kgr peso/semana de AMPD durante 8 semanas. y otro grupo de 15 pacientes (Grupo 11), recibió una dosis de 5 mgr/Kgr peso/semana de AMPD durante el mismo tiempo.Se hizo un seguimiento clínico-histológico, que varió de 6 a 54 meses, con un promedio de 18 meses. Se observó mejoria histológica al mes de iniciada la terapia en el 63% de los pacientes, y un mes después de terminada la misma, en 100% de los pacientes de ambos grupos no existia indicios del diagnóstico inicial.A través del seguimiento se observó mejoria clínica en el 61% de los pacientes del Grupo I, (16/26), y en el 87% del Grupo II (13/15). Hubo 10 casos (38%) de recurrencia clínica en el Grupo I y 3 casos (20%) en el Grupo II. Solo hubo 1 caso de recurrencia histológica en el Grupo 1 y ninguna en el grupo 11. Aquellos pacientes que presentaron recurrencia, recibieron un segundo ciclo de tratamiento con el doble de la dosis inicial, y de estos 3 casos se consideraron fracasos por evolución clínica desfavorable; sin embargo, al ser intervenidos quirúrgicamente se encontró una causa orgánica (adenomiosis miomatosis), posiblemente responsable de la evolución clínica de estos casos.Finalmente en forma paralela se verificó la confiabilidad de la Biopsia de Endometrio para el seguimiento de estos casos, encontrándose una excelente correlación entre los resultados histopatológicos encontrados en el Legrado Uterino y la Biopsia de Endometrio practicados a una misma paciente (Coeficiente de Correlación, r = 0 ,870 p<<0.001). El manejo médico de la Hiperplasia ofrece ventajas para aquellas pacientes de riesgo quirúrgico alto, o para quienes no acepten esta via.

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Present Status of Injectable Contraceptives: Results of Seven-Years Study

Cited by 37 publications

References 14 publications

Return of menstruation and fertility in Thai women after contraceptive injections

Return of menstruation and fertility in Thai women after contraceptive injections

Medroxyprogesterone acetate inhibits wound closure of human endometrial epithelial cells and stromal fibroblasts in vitro

Manejo de la hiperplasia endometrial con acetato de medroxiprogesterona de depósito

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