Preservation microbiology and safety: Evidence that stress enhances virulence and triggers adaptive mutations

Archer, Douglas L.

doi:10.1016/0924-2244(96)81303-3

Cited by 116 publications

(69 citation statements)

References 11 publications

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“…Examples of such bacteriostatic or bactericidal stresses include extremes of temperature, pH, osmotic pressure, depletion of nutrients (6), and the presence of toxic or inhibitory compounds, including antibiotics (26). Many modern food preservation processes aim to extend the lag phase of bacteria present in food by the application of one or more environmental stresses to slow or prevent bacterial growth.…”

mentioning

confidence: 99%

Environmental Stress and Antibiotic Resistance in Food-Related Pathogens

McMahon

Moore

et al. 2007

Appl Environ Microbiol

221

140

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This study investigated the possibility that sublethal food preservation stresses (high or low temperature and osmotic and pH stress) can lead to changes in the nature and scale of antibiotic resistance (ABR) expressed by three food-related pathogens (Escherichia coli, Salmonella enterica serovar Typhimurium, and Staphylococcus aureus). The study found that some sublethal stresses significantly altered antibiotic resistance. Incubation at sublethal high temperature (45°C) decreased ABR. Incubation under increased salt (>4.5%) or reduced pH (<5.0) conditions increased ABR. Some of the pathogens continued to express higher levels of ABR after removal of stress, suggesting that in some cases the applied sublethal stress had induced stable increases in ABR. These results indicate that increased use of bacteriostatic (sublethal), rather than bactericidal (lethal), food preservation systems may be contributing to the development and dissemination of ABR among important food-borne pathogens.

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mentioning

confidence: 99%

Environmental Stress and Antibiotic Resistance in Food-Related Pathogens

McMahon

Moore

et al. 2007

Appl Environ Microbiol

221

140

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“…In response to the generation of resistance mechanisms in bacteria when exposed to a particular stress, cross protection has also been shown to manifest across multiple stresses [10,11]. Baillon et al [29] have shown that iron regulated proteins of Campylobacter jejuni are involved in its defense against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…There is some indication from the existing literature that if stress tolerance occurs in a bacterium when exposed to a single stressor, cross protection can be manifested across multiple stresses and general tolerance of these environments is increased [10,11]. Iron responsive regulator Fur has been found to be directly or indirectly involved in regulation of oxidative stress defense [12].…”

Section: Introductionmentioning

confidence: 99%

Coordinated expression and immunogenicity of an outer membrane protein from Salmonella enterica serovar Typhi under iron limitation, oxidative stress and anaerobic conditions

et al. 2005

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SummarySuccessful pathogens overcome the environmental stresses by the coordinated expression of various genes and eventually proteins. Since, the surface of the microbe is likely to come in contact with the host initially, an attempt was made to identify the outer membrane proteins (OMPs), if any, which may get expressed under more than one environmental conditions simulating the in vivo ones. In the present study, Salmonella enterica serovar Typhi was grown under iron-limited, oxidative stress as well as anaerobic conditions and the OMP profiles were compared. A 69 kDa OMP was found to express with enhanced intensity under the selected stress conditions in comparison to normal conditions. The phenotypic similarity among the proteins was assessed on the basis of their molecular weight, cross reactivity and HPLC. The protein expressed under oxidative stress and anaerobic conditions reacted with the antibodies raised against iron-regulated outer membrane protein (IROMP), indicating the sharing of at least some of the epitopes. A single peak observed after subjecting the pooled 69 kDa protein sample and appearance of a single band on SDS-PAGE thereafter, confirmed the purity and phenotypic similarity of the 69 kDa OMP. Reactivity of pooled 69 kDa protein with 85% of sera from typhoid patients revealed the in vivo expression of this protein. The results of this study indicate the coordination of this phenotype under iron stress, oxidative stress and anaerobic conditions. In view of the expression of the 69 kDa protein under the selected stress conditions and their in vivo immunogenicity, these findings may be relevant for the better understanding of the host-microbe interactions and for the further development of diagnostic and preventive strategies.

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“…Heat-shock and other environmental stresses are also reported to affect the virulence of L. monocytogenes. Environmental stresses are sensed by pathogens as sig- nals for expression of virulence factors to enhance survival (Archer, 1996). Heat shock may also increase the virulence of L. monocytogenes enhancing more listeriolysin O production.…”

Section: Thermal Resistance Of L Monocytogenes Fstlc55 Isolated Frommentioning

confidence: 99%

Evaluation of the heat resistance of pathogenic <i>Listeria monocytogenes</i> in milk and milk products in Sri Lanka

Jayamanne

Samarajeewa

2011

Trop Agric Res & Ext

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Preservation microbiology and safety: Evidence that stress enhances virulence and triggers adaptive mutations

Cited by 116 publications

References 11 publications

Environmental Stress and Antibiotic Resistance in Food-Related Pathogens

Environmental Stress and Antibiotic Resistance in Food-Related Pathogens

Coordinated expression and immunogenicity of an outer membrane protein from Salmonella enterica serovar Typhi under iron limitation, oxidative stress and anaerobic conditions

Evaluation of the heat resistance of pathogenic <i>Listeria monocytogenes</i> in milk and milk products in Sri Lanka

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