“…Several studies have described different stimuli to evaluate pain thresholds, such as pressure [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ], heat [ 11 , 12 ], electric current [ 13 , 14 , 15 , 16 , 17 , 18 ], and intra-epidermal injection of chemical substances (e.g., capsaicin [ 19 ] or acid type solution at pH 4.3 [ 20 ]). Despite the fact that the most abundant nociceptors are polymodal, generally different stimuli activate different nociceptors clusters; for this reason, it is important to study all kinds of stimuli to improve all technical aspects of pain threshold evaluation.…”