“…This also causes protein stress and damage. An interesting idea is that this stress and damage are coupled to protein- and organelle-turnover including that, across species, neuronal activity induces the formation of autophagosomes at synapses (Decet and Verstreken, 2021; Hill et al, 2019; Kroemer et al, 2010; Kulkarni et al, 2021; Nakatogawa, 2020; Nixon, 2013; Shehata et al, 2012; Soukup et al, 2016; Wang et al, 2015; Yang et al, 2022). However, how elements of neuronal activity such as calcium influx, neurotransmitter release or endocytosis, drive the formation of autophagosomes at synaptic terminals has not been investigated.…”