Preterm labor is induced by intraamniotic infusions of interleukin-1β and tumor necrosis factor-α but not by interleukin-6 or interleukin-8 in a nonhuman primate model

Sadowsky, Drew W.; Adams, Kristina M.; Gravett, Michael G.; Witkin, Steven S.; Novy, Miles J.

doi:10.1016/j.ajog.2006.06.072

Cited by 311 publications

(245 citation statements)

References 29 publications

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“…(1) stimulation of IL-1R induces the transcription of numerous pro-labor genes via MAPK p38, JNK, c-jun and small GTPase Rho in myometrial smooth muscle cells, which results in increased myometrial contractility (Tribe et al 2003, Chevillard et al 2007, Nadeau-Vallee et al 2015b; and preterm labor in mice and non-human primates (Romero et al 1991, Sadowsky et al 2006; (2) antagonism of IL-1R prevents all of these events (Romero & Tartakovsky 1992, Nadeau-Vallee et al 2015b; (3) IL-1α amniotic fluid levels are elevated in women that deliver preterm (Figueroa et al 2005); (4) preterm labor is associated with increased IL-1α activity in amniotic fluids (Romero et al 1989); and (5) maternal polymorphisms and haplotypes in the IL-1α gene (Sata et al 2009), as well as fetal polymorphism in the endogenous IL-1R antagonist (Witkin et al 2003), have been associated with increased risk of preterm birth. The critical role of IL-1 in preterm labor has been reviewed elsewhere (Nadeau-Vallee et al 2015a).…”

Section: Preterm Labormentioning

confidence: 99%

Sterile inflammation and pregnancy complications: a review

Nadeau-Vallée¹,

Obari²,

Palacios³

et al. 2016

Reproduction

219

161

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Inflammation is essential for successful embryo implantation, pregnancy maintenance and delivery. In the last decade, important advances have been made in regard to endogenous, and therefore non-infectious, initiators of inflammation, which can act through the same receptors as pathogens. These molecules are referred to as damage-associated molecular patterns (DAMPs), and their involvement in reproduction has only recently been unraveled. Even though inflammation is necessary for successful reproduction, untimely activation of inflammatory processes can have devastating effect on pregnancy outcomes. Many DAMPs, such as uric acid, high-mobility group box 1 (HMGB1), interleukin (IL)-1 and cell-free fetal DNA, have been associated with pregnancy complications, such as miscarriages, preeclampsia and preterm birth in preclinical models and in humans. However, the specific contribution of alarmins to these conditions is still under debate, as currently there is lack of information on their mechanism of action. In this review, we discuss the role of sterile inflammation in reproduction, including early implantation and pregnancy complications. Particularly, we focus on major alarmins vastly implicated in numerous sterile inflammatory processes, such as uric acid, HMGB1, IL-1α and cell-free DNA (especially that of fetal origin) while giving an overview of the potential role of other candidate alarmins.Reproduction (2016) 152 R277-R292

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Section: Preterm Labormentioning

confidence: 99%

Sterile inflammation and pregnancy complications: a review

Nadeau-Vallée¹,

Obari²,

Palacios³

et al. 2016

Reproduction

219

161

View full text Add to dashboard Cite

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“…TNF can amplify or initiate the process of parturition by further increasing cytokine production, increasing PTGS2-mediated prostaglandin synthesis and activating MMPs (Roh et al 2000, Bowen et al 2002, Keelan et al 2003, Lappas & Rice 2004, Christiaens et al 2008, Tattersall et al 2008. In addition, TNF can induce preterm labour in animal models (Sadowsky et al 2006). Thus, it was also of interest to determine if RAF1 also regulates pro-inflammatory and pro-labour mediators in the presence of TNF.…”

Section: Discussionmentioning

confidence: 99%

“…Human labour is associated with increased concentrations of IL1B in both gestational tissues and biological fluids (Elliott, et al 2001, Bowen et al 2002, Tattersall et al 2008, and intra-amniotic and/or systemic administration of IL1B to mice and monkeys induces preterm labour (Romero et al 1991, Romero & Tartakovsky 1992, Sadowsky et al 2006. IL1B is thought to contribute to the onset of labour by stimulating and potentiating uterine contractions.…”

Section: Discussionmentioning

confidence: 99%

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RAF1 is increased in labouring myometrium and modulates inflammation-induced pro-labour mediators

Lappas¹

2016

Reproduction

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Inflammation plays a central role in the terminal process of human labour and delivery, including myometrial contractions. RAF1 protooncogene serine/threonine-protein kinase (RAF1) can activate ERK (official gene symbol MAPK1) and/or nuclear factor-kappa B (NF-kB) to regulate genes involved in inflammation. There are, however, no studies on the role of RAF1 in the processes of human labour and delivery. Thus, the aims of this study were to determine the effect of i) human labour and pro-inflammatory cytokines interleukin 1 beta (IL1B) and tumour necrosis factor (TNF) alpha on RAF1 protein expression in myometrium and ii) siRNA knockdown of RAF1 on proinflammatory and pro-labour mediators in human myometrial primary cells. Term labour was associated with an increase in RAF1 protein expression. Furthermore, RAF1 protein expression was increased in myometrial cells treated with IL1B and TNF, two likely factors contributing to preterm birth. Knockdown of RAF1 by siRNA in primary myometrial cells significantly decreased IL1B-and TNF-induced IL1A, IL1B, IL6, (C-X-C motif) ligand 8 (CXCL8)and chemokine (C-C motif) ligand 2 (CCL2) mRNA abundance and IL6, IL8 and CCL2; prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA levels and prostaglandin PGF 2a release; and NF-kB activation. Furthermore, RAF1 knockdown was associated with decreased activation of ERK in the presence of IL1B but not TNF. Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF 2a release; and NF-kB activation. In conclusion, IL1B induces the expression and secretion of pro-labour mediators through the RAF1-MAPK1-NF-kB signalling pathway. TNF, on the other hand, regulates pro-labour mediators through the RAF1-NF-kB signalling pathway via an MAPK1-independent mechanism.

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“…In contrast to the sheep model, amniotic fluid inoculation with Ureaplasma in the Rhesus model at ϳ75% gestation results in a progressive increase in uterine contractility culminating in preterm labor, suggesting a unique species difference in host response (52,65). Nearly 80% of preterm births occurred within 1 wk of inoculation and all occurred within 15 days.…”

Section: Ureaplasma Modelmentioning

confidence: 99%

Animal models of bronchopulmonary dysplasia. The preterm baboon models

Yoder

Coalson

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

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Yoder BA, Coalson JJ. Animal models of bronchopulmonary dysplasia. V. The preterm baboon models. Am J Physiol Lung Cell Mol Physiol 307: L970 -L977, 2014. First published October 3, 2014 doi:10.1152/ajplung.00171.2014.-Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we highlight how the preterm baboon model at both 140 and 125 days gestation (term equivalent 185 days) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-day baboon model extremely relevant to the condition of bronchopulmonary dysplasia but there are also critical neurodevelopmental and other end-organ pathological features associated with this model not fully discussed in this limited forum. We also describe efforts to incorporate perinatal infection into these preterm models, both fetal and neonatal, and particularly associated with Ureaplasma/Mycoplasma organisms. Efforts to rekindle the preterm primate model for future evaluations of therapies such as stem cell replacement, early lung recruitment interventions coupled with noninvasive surfactant and high-frequency nasal ventilation, and surfactant therapy coupled with antioxidant or anti-inflammatory medications, to name a few, should be undertaken.baboon; bronchopulmonary dysplasia; lung; preterm infant; ureaplasma OF THE NEARLY 4,000,000 annual births in the United States, ϳ1% (ϳ40,000) occur at Ͻ29-wk gestation. Advances in prenatal and neonatal care have contributed to marked improvements in survival rates for these extremely immature infants, with many centers reporting survival rates Ͼ90% for infants in the 25-to 28-wk range (71). However, increasing survival of these fragile infants has been accompanied by high rates of bronchopulmonary dysplasia (BPD), the most common morbidity affecting extremely preterm infants (66,71,96). Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, including approaches to mechanical ventilation, surfactant therapy, and application of noninvasive respiratory support, has been derived through investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we will highlight how primate models, particularly the preterm baboon model at both 140 days and 125 days gestation (term equivalent 185 days), have advanced our understanding and management of the immature human infant with neonatal lung disease; identify limitations to this and other animal models in the quest to prevent BPD; and suggest future directions to improve animal modeling and translational research to further improve outcomes. 140-Day Model ("Old BPD")The first long-term animal model for neonatal BPD in the 140-day premature baboon was developed in the early 1980s (19,26). At that time surfactant replacement therapy had not been approved for human use. Additi...

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Preterm labor is induced by intraamniotic infusions of interleukin-1β and tumor necrosis factor-α but not by interleukin-6 or interleukin-8 in a nonhuman primate model

Cited by 311 publications

References 29 publications

Sterile inflammation and pregnancy complications: a review

Sterile inflammation and pregnancy complications: a review

RAF1 is increased in labouring myometrium and modulates inflammation-induced pro-labour mediators

Animal models of bronchopulmonary dysplasia. The preterm baboon models

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