2006
DOI: 10.1203/01.pdr.0000228333.11132.fa
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Preterminal Gasping During Hypoxic Cardiac Arrest Increases Cardiac Function in Immature Rats

Abstract: Newborn animals are more resistant to anoxia than older animals, partly due to an increased tolerance of the immature heart to anoxia. Newborn animals also have a more robust preterminal gasp. We investigated the relationship between gasping and cardiac function in immature and maturing rats exposed to anoxia. Immature postnatal day 7 (PND7) rats (n ϭ 13) and maturing PND17 rats (n ϭ 13) were exposed to 100% nitrogen (anoxia) for 10 min. Echocardiography was used to calculate cardiac contractility (CC) by left… Show more

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Cited by 23 publications
(13 citation statements)
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“…These pressure gradients augment effective forward blood flow [17]. Improved cardiac output and cardiac contractility by gasping have been confirmed in a rat model [16]. Consequently, increased aortic pressure and coronary perfusion pressure [17,21], increased carotid blood flow [21], and decreased intracranial pressure with associated gasping during ventricular fibrillation [20] have been demonstrated.…”
Section: Effect Of Gasping On Cardiovascular Functionsmentioning
confidence: 85%
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“…These pressure gradients augment effective forward blood flow [17]. Improved cardiac output and cardiac contractility by gasping have been confirmed in a rat model [16]. Consequently, increased aortic pressure and coronary perfusion pressure [17,21], increased carotid blood flow [21], and decreased intracranial pressure with associated gasping during ventricular fibrillation [20] have been demonstrated.…”
Section: Effect Of Gasping On Cardiovascular Functionsmentioning
confidence: 85%
“…The occurrence of gasping has been described in cardiac arrest models in both rats [15,16] and swine [17][18][19][20][21].…”
Section: Animal Cardiac Arrest Modelsmentioning
confidence: 99%
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“…In combination with unconsciousness it is considered a pathognomonic sign of cardiac arrest 8,9 . It is a common mammalian pattern of breathing based on the simple brain stem reflex expressed in the setting of cerebral hypoxia 10 . The beneficial effect of gasping on circulation and gas exchange during cardiac arrest has been described [11][12][13][14] .…”
Section: Discussionmentioning
confidence: 99%
“…The beneficial effect of gasping on circulation and gas exchange during cardiac arrest has been described [11][12][13][14] . It has been formerly hypothesized that gasping is a protective mechanism for anoxia during delivery of immature animals 10 . The reported incidence of gasping fluctuates between 33 and 60% in all OHCA patients 1,15,16 .…”
Section: Discussionmentioning
confidence: 99%