Pretibial myxedema in a euthyroid patient without history of autoimmune thyroid disease

Abstract

Introduction: Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves' disease (GD), in about 1-5% of patients, usually co-existing with Graves' orbitopathy. PM constitutes one of the classical forms of dermopathy in GD, presenting with a variety of symptomatology (from asymptomatic erythema to severe elephantiasic form). PM usually occurs during the hyperthyroid state of GD. PM has also rarely been described in patients with Hashimoto thyroiditis.