Pretransplant absolute monocyte count in peripheral blood predicts posttransplant tumor prognosis in patients undergoing liver transplantation for hepatocellular carcinoma

Kim, Young-Kyu; Kim, Seong Hoon; Lee, Seung-Duk; Lee, Soon-Ae; Park, Sang-Jae

doi:10.1016/s1499-3872(14)60251-4

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…In kidney and liver transplant patients, elevated numbers of circulating monocytes correlate with poor graft function. 44,45 Furthermore, macrophages constitute up to 60% of the immune cell infiltrates in biopsies from severe kidney rejection. 46 DAMPs, such as heat shock protein 60, heat shock protein 70, surfactant protein-A, and high mobility group box 1 (HMGB1) are released during transplantation and induce proinflammatory responses in innate immune cells.…”

Section: Trained Innate Immunity In Solid Organ Transplantationmentioning

confidence: 99%

Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation

Cunningham

Mills

2021

Transplantation

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Although significant progress has been made to improve short-term survival of transplant patients, long-term acceptance of allografts in solid organ and hematopoietic stem cell (HSC) transplantation is still a significant challenge. Current therapeutics for preventing or treating allograft rejection rely on potent immunosuppressive drugs that primarily target T cells of the adaptive immune response. Promising advances in transplant immunology have highlighted the importance of innate immune responses in allograft acceptance and rejection. Recent studies have demonstrated that innate immune cells are capable of mediating memory-like responses during inflammation, a term known as trained innate immunity. In this process, innate immune cells, such as macrophages and monocytes, undergo metabolic and epigenetic changes in response to a primary stimulus with a pathogen or their products that result in faster and more robust responses to a secondary stimulus. There is also some evidence to suggest that innate immune cells or their progenitors may be more anti-inflammatory after initial stimulation with appropriate agents, such as helminth products. Although this phenomenon has primarily been studied in the context of infection, there is emerging evidence to suggest that it could play a vital role in transplantation rejection and tolerance. Mechanisms of training innate immune cells and their progenitors in the bone marrow are therefore attractive targets for mediating long-term solid organ and HSC transplant tolerance. In this review, we highlight the potential role of proinflammatory and anti-inflammatory mechanisms of trained innate immunity in solid organ and HSC transplantation.

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Section: Trained Innate Immunity In Solid Organ Transplantationmentioning

confidence: 99%

Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation

Cunningham

Mills

2021

Transplantation

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“…In HCC, infiltration of proinflammatory macrophages into the tumor microenvironment was shown to enhance tumor growth and to be associated with invasion and metastases . An absolute monocyte count in peripheral blood > 200/mm 3 was also found to correlate with tumor recurrence after liver transplantation . [ 18 F]FDG is taken up at sites of inflammation, and this may be a mechanism to explain its ability to predict recurrence.…”

Section: [18f]fludeoxyglucose Positron Emission Tomography–computed Tmentioning

confidence: 99%

“…27 An absolute monocyte count in peripheral blood > 200/mm 3 was also found to correlate with tumor recurrence after liver transplantation. 28 [ 18 F]FDG is taken up at sites of inflammation, and this may be a mechanism to explain its ability to predict recurrence. Notably, the new amino acid tracers, which do not accumulate in inflamed tissues, will be able in the future to improve diagnostic yield and increase sensitivity.…”

Section: [ 18 F]fludeoxyglucose Positron Emission Tomography-computedmentioning

confidence: 99%

[18F]fludeoxyglucose positron emission tomography and computed tomography as a prognostic tool before liver transplantation, resection, and loco‐ablative therapies for hepatocellular carcinoma

et al. 2015

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Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. Orthotopic liver transplantation (OLT) and resection are curative treatment options for well-selected patients with HCC, whereas loco-ablative therapy has been shown to prolong survival. Organ and treatment allocations for these patients are currently based on the number and size of tumors, as defined by the Milan criteria, and on functional capacity, and they are incorporated into the Barcelona Clinic Liver Cancer staging system and treatment strategy. Even though these staging criteria have markedly improved the outcomes of patients with HCC, they still lack accuracy in predicting the risk of tumor recurrence because they do not incorporate markers of tumor biology and behavior. Positron emission tomography (PET) and computed tomography (CT) with Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. 1 Orthotopic liver transplantation (OLT) is a curative treatment option for patients with HCC who meet strict criteria. Initial success with OLT was hampered by poor survival

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“…After thoroughly screening the titles and abstracts by two investigators independently, the full‐texts of 173 potential studies were selected for further identification. Finally, 102 retrospective studies and 2 retrospective‐prospective studies from 93 eligible papers that met the inclusion criteria were included in this meta‐analysis 22–24,30–119 . The flow diagram of the selection procedure is presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Elevated peripheral absolute monocyte count related to clinicopathological features and poor prognosis in solid tumors: Systematic review, meta‐analysis, and meta‐regression

Wen

Chen

et al. 2021

Cancer Medicine

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Pretransplant absolute monocyte count in peripheral blood predicts posttransplant tumor prognosis in patients undergoing liver transplantation for hepatocellular carcinoma

Cited by 8 publications

References 22 publications

Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation

Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation

[18F]fludeoxyglucose positron emission tomography and computed tomography as a prognostic tool before liver transplantation, resection, and loco‐ablative therapies for hepatocellular carcinoma

Elevated peripheral absolute monocyte count related to clinicopathological features and poor prognosis in solid tumors: Systematic review, meta‐analysis, and meta‐regression

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