Pretransplant Soluble CD30 Level Has Limited Effect on Acute Rejection, but Affects Graft Function in Living Donor Kidney Transplantation

Abstract

PreTx sCD30 level has a limited effect on the incidence of acute rejection and response to antirejection treatment, but inversely and independently affects serum creatinine level after living donor kidney transplantation.

Kidney graft recipients with pretransplantation HLA CLASS I antibodies and high soluble CD30 are at high risk for graft loss

“…Another pretransplantation risk factor that has received much attention recently is the sCD30 serum level [13][14][15][16][17]21,22,26]. Several reports show that elevated sCD30 levels, pre-and post-transplantation are associated with a poor prognosis for long term kidney graft survival.…”

“…Recently, evidence has been gathered regarding the T-cell activation marker soluble CD30 (sCD30) as an independent predictor of immunologic risk in renal transplant recipients without preformed alloantibodies [13][14][15][16][17]. This evidence suggests that the measurement of sCD30 levels offers relevant clinical information regarding rejection risk and can contribute to the selection of the appropriate immunosuppresive regimen in high-risk recipients for the prevention of acute rejection and chronic allograft nephropathy [13,14,16].…”

Soluble CD30 and Acute Renal Allograft Rejection

“…It was found an association between CD4 helper function and sCD30 2 years post-transplant, both in Cyclosporine-A and Tacrolimus treated patients, which might be the result of diminished suppression of CD4 helper activity due to reduced Calcineurin inhibitor drug exposure (Weimer R. et al, 2000). This evidence suggests that the measurement of sCD30 levels offers relevant clinical information regarding rejection risk and can contribute to the selection of the appropriate immunosuppressive regimen in high-risk recipients for the prevention of acute rejection and chronic allograft nephropathy (Kim MS et al 2006).…”

Pretransplantation Soluble CD30 Level As a Predictor of Acute Rejection in Kidney Transplantation

“…All the included studies detected pretransplantation serum concentrations of sCD30 using an enzyme-linked immunosorbent assay technique except for one study using microsphere flow-cytometry assay. Among the 12 studies, 5 were performed in Europe (9,12,15,16,20), 3 in America (11,18,19), and 4 in Asia (10,13,14,17). All studies were retrospective cohort studies and did not adopt blind design.…”