Pretreatment biopsy for thymic epithelial tumors—does histology subtype matter for treatment strategy?

Padda, Sukhmani K.; Keijzers, Marlies; Wakelee, Heather A.

doi:10.21037/jtd.2016.06.77

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…До 2014 года стадирование ЭОТ выполнялось по классификации Masaoka-Koga [ Однако, учитывая низкую информативность исследования, невозможность определения типа опухоли и высокий риск имплантационного метастазирования, метод аспирационной биопсии в настоящий момент не рекомендуется к выполнению [18]. Данные отрицательные моменты отсутствуют при трансторакальной трепанобиопсии, ввиду этого данный метод диагностики рекомендован при необходимости предоперационной гистологической верификации [19][20][21].…”

Section: классификация эпителиальных опухолей тимусаunclassified

Surgical Treatment of Stage I and II Thymus Epithelial Tumors

Epifantsev,

Gritsun,

Keshvedinova

et al. 2023

Journal of Clinical Practice

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Thymic epithelial tumors are the most common tumors of the anterior mediastinum, with an incidence of 0.18 per 100,000 population. Here, we present a review of the national and foreign literature on the surgical treatment of stage I and II thymic epithelial tumors. The Medline (PubMed) and Russian Science Citation Index (eLibrary) databases were used as search engines. The focus of the review is the problem of choosing the optimal minimally invasive surgical approach for thymectomy, and the need for lymph node dissection for thymic epithelial tumors. A number of issues remain currently unresolved in thymic epithelial tumors surgery, namely the justification of the preoperative histological verification of the tumor process, the choice of the optimal surgical access to the anterior mediastinum, the need for and prognostic effect of lymph node dissection, and the determination of the required volume of the planned operation.

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Section: классификация эпителиальных опухолей тимусаunclassified

Surgical Treatment of Stage I and II Thymus Epithelial Tumors

Epifantsev,

Gritsun,

Keshvedinova

et al. 2023

Journal of Clinical Practice

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“…Thus, it has no place in diagnosis or treatment of noninvasive thymic tumors amenable to surgery. It can be performed if clinically and radiographically suspected thymoma or other thymic tumor is not amenable to surgical resection owing to its locally advanced stage and pleural involvement (invasion into pleural space, pleural effusion or metastasis to pleura) (6,(56)(57)(58).…”

Section: Medical Thoracoscopymentioning

confidence: 99%

How to obtain adequate biopsy specımen in suspected thymic tumors

Bilaçeroğlu¹

2020

J Thorac Dis

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Pathologic diagnosis of thymic tumors (TTs) can be made by surgical or nonsurgical procedures. About 20% of TTs had been diagnosed by pretreatment biopsy methods while the rest had gone to surgery for diagnosis and treatment. However, in the last two decades there was an increase in pretreatment procedures for optimal management of locally advanced or metastatic TTs. Pretreatment tissue diagnosis of a noninvasive TT is not a standard option but is required if there is suspect or atypical clinical presentation and imaging, an invasive tumor requiring a nonsurgical approach or preoperative chemotherapy or chemoradiotherapy, strong possibility of lymphoma or unclear differential diagnosis between lymphoma or other solid tumor by imaging studies, or suspicion of a metastatic lesion. In surgical diagnosis anterior mediastinotomy, video-assisted thoracic surgery or mediastinoscopy can be chosen for invasive TTs whereas total resection is performed for small, noninvasive tumors. Nonsurgical diagnosis can be made by transthoracic fine or core needle biopsies (TTFNA, TTCNB), conventional bronchoscopy, endobronchial ultrasonography-guided transbronchial needle aspiration (EBUS-TBNA), endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) or medical thoracoscopy depending on procedural amenability according to tumor extension. TTFNA and TTCNB have been the most frequently used nonsurgical methods. However, there is an upward trend in using conventional bronchoscopy, EBUS-TBNA, EUS-FNA and medical thoracoscopy recently. To increase the diagnostic performance of these procedures in TTs, recommendations are (I) obtaining histologic specimens, (II) combining smears or liquid based cytology preparations and cell blocks, (III) obtaining multiple sufficient samples, (IV) combining histologic and cytologic specimens, (V) performing morphologic, immunohistochemical and molecular analyses on all specimens, (VI) using rapid onsite evaluation for cytologic specimens, (VII) correlating pathologic, clinical and radiologic findings, (VIII) consulting experienced pathologists.

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