Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer

Tsai, Yu-Duan; Wang, Chao-Ping; Chen, Chih-Yu; Lin, Lih‐Chang; Hwang, Tzer‐Zen; Liu, Lu; Hsu, Hsia-Fen; Chung, Fu‐Mei; Lee, Yau-Jiunn; Houng, Jer-Yiing

doi:10.1002/hed.23400

Cited by 79 publications

(119 citation statements)

References 46 publications

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“…They also reported that NLR might be a promising serum biomarker for diagnosis and prognostication of PTC (Seretis et al, 2013). In another study, Tsai et al reported an increase in NLR in parallel with the advancement of clinical stage in the patients with oral cavity cancer, and in contrast, a reduction in the lymphocyte count (Tsai et al, 2013). Similarly, pretreatment NLR was found as a strong prognostic factor in nasopharyngeal carcinoma patients .…”

Section: Discussionmentioning

confidence: 93%

“…The presence of an elevated preoperative NLR has been validated as a marker of inflammation, and shown to have prognostic significance for a number of tumors (Jung et al, 2011;Idowu et al, 2012;Liu et al, 2013;Unal et al, 2013), including HNSCC (Trellakis et al, 2011;Millrud et al, 2012;Perisanidis et al, 2013;Rassouli et al, 2013;Tsai et al, 2013). It is considered as a marker of systemic inflammation which may predict worse prognosis by driving cancer cell proliferation through increasing the availability of growth factors, angiogenic factors and other pro-neoplastic signaling molecules (Hanahan and Weinberg, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Elevated Neutrophil-to-Lymphocyte Ratio in Squamous Cell Carcinoma of Larynx Compared to Benign and Precancerous Laryngeal Lesions

Kum¹,

Özcan²,

Baklacı³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Laryngeal carcinogenesis is a multifactorial process that has not been fully elucidated. Despite extensive research, reliable markers with diagnostic and prognostic value are still lacking. It was recently reported that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) may correlate with an increased risk of recurrence, tumor aggressiveness and poorer prognosis in various malignancies. The aim of this study was to examine whether NLR could be used as an inflammatory marker to differentiate laryngeal squamous cell carcinoma (LSCC) patients from benign laryngeal lesion (BLL) and precancerous laryngeal lesion (PLL) patients. Materials and Methods: This retrospective study was performed on 209 patients admitted to a tertiary referral center with laryngeal lesions and undergoing biopsies to establish their histopathological diagnosis. We reviewed the patient files for their clinical, histopathological and laboratory data. The patients were divided into three groups according to their histopathological findings, as BLL, PLL and LSCC groups. The patients in the PLL group were also divided into three subgroups as mild, moderate and severe dysplasia/ carcinoma in situ (CIS) subgroups. The groups were compared for NLR and the other laboratory data. Results: The mean NLRs of the BLL, PLL and the LSCC groups were 2.12±0.86, 2.32±0.68 and 3.46±1.51, respectively, and the difference was statistically significant (p=0.001). The mean NLRs of the patients with PLL and LSCC were significantly higher than the patients with BLL (p=0.031 and p=0.001, respectively). The mean NLRs were similar among mild dysplasia, moderate dysplasia and severe dysplasia / CIS groups (p>0.05). Conclusions: To our knowledge, this is the first study investigating NLR in BLL, PLL and LSCC. NLR is an inexpensive, reproducible and widely available blood test, and could be a useful inflammatory marker to differentiate LSCC from BLL and PLL.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Elevated Neutrophil-to-Lymphocyte Ratio in Squamous Cell Carcinoma of Larynx Compared to Benign and Precancerous Laryngeal Lesions

Kum¹,

Özcan²,

Baklacı³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Neutrophilia may be a marker of inflammation-related aggressive biological behaviour of the tumor (18). Absolute neutrophil and lymphocyte counts may be affected by various physiological, pathological and physical factors, although NLR may remain stable with respect to these factors.…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophilia may inhibit the immune system by suppressing lymphocytes, activated T cells and natural killer cells (3,17). The prognostic role of the NLR has been evaluated in >60 studies on a number of solid tumors (7)(8)(9)(10)(11)(12)(13)(14)16,18).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer

Salim

Mutlu

Eryılmaz

et al. 2015

Molecular and Clinical Oncology

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Abstract. The neutrophil to lymphocyte ratio (NLR) has been widely investigated for its prognostic significance in cancer.In the present study, we aimed to determine whether NLR is a prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC). A total of 79 patients from the Akdeniz University database were retrospectively analyzed. The cut-off NLR was set at 2.93; patients with NLR >2.93 had a median overall survival (OS) of 12.1 months, whereas the median OS was not reached for patients with NLR ≤2.93 (P= 0.027). On multivariate analysis, NLR and recurrence or metastatic site were found to be independent prognostic factors for OS (P= 0.014 and P= 0.002, respectively). Therefore, NLR was identified as an independent prognostic factor for OS in patients with recurrent or metastatic HNSCC.

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“…These findings are consistent with the work of Tsai et al, who reported that pretreatment total WBCs count, NC, LC and NLR were not significantly associated with cancer-specific survival in oral cancer patients. Instead, the authors found that pretreatment monocytes count had a significant association with survival in these patients (12) .…”

Section: Discussion:-mentioning

confidence: 93%

Systemic Markers and Survival of Oral Cancer Patients in Egypt.

Sobeih¹,

Elsharawy²,

Shams³

et al. 2017

IJAR

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Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer

Abstract: A higher pretreatment circulating monocyte count can be considered as a useful prognostic marker in patients with oral cavity cancer.

Cited by 79 publications

References 46 publications

Elevated Neutrophil-to-Lymphocyte Ratio in Squamous Cell Carcinoma of Larynx Compared to Benign and Precancerous Laryngeal Lesions

Elevated Neutrophil-to-Lymphocyte Ratio in Squamous Cell Carcinoma of Larynx Compared to Benign and Precancerous Laryngeal Lesions

Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer

Systemic Markers and Survival of Oral Cancer Patients in Egypt.

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