Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial

Cédrin‐Durnerin, Isabelle; Guivarc'h-Levêque, Anne; Hugues, Jean‐Noël

doi:10.1016/j.fertnstert.2012.02.028

Cited by 36 publications

(34 citation statements)

References 25 publications

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“…Women underwent controlled ovarian stimulation by an antagonist protocol with estrogen pretreatment [12]. Recombinant human chorionic gonadotropin (hCG) was administered when three or more follicles were >17 mm in diameter with the lead follicle ≥18 mm.…”

Section: Methodsmentioning

confidence: 99%

Does sperm origin affect embryo morphokinetic parameters?

Lammers

Reignier

Splingart

et al. 2015

J Assist Reprod Genet

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Purpose The purpose of our study was to use time-lapse in order to evaluate the impact of sperm origin (fresh ejaculate or surgically retrieved) on embryo morphokinetic parameters and clinical outcome in intracytoplasmic sperm injection (ICSI) cycles. Methods This retrospective monocentric study was conducted in 485 unselected couples undergoing 604 ICSI cycles with embryo culture in the Embryoscope®. Among them, 445 couples underwent ICSI cycle with fresh ejaculated sperm and 40 with surgically retrieved sperm (26 with testicular sperm and 14 with epididymal sperm). Embryo morphokinetic parameters and clinical cycle outcome were compared between fresh ejaculated sperm and surgically retrieved sperm. A subgroup analysis was also conducted between testicular and epididymal sperm ICSI cycles.Results Clinical outcome was comparable between groups according to sperm origin. Although most early morphokinetic parameters were comparable between ejaculated and surgical sperm groups, a few parameters were significantly different between both groups, but with a considerable overlap in their distribution. Late cellular events occurred significantly later in the surgical sperm group than in the ejaculated sperm group. Conclusions Morphokinetic analysis did not allow us to identify clinically relevant differences between fresh ejaculate and surgically retrieved sperm groups. Further studies are needed, especially concerning the relationship between sperm origin and late morphokinetic parameters, such as blastocyst development.

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Section: Methodsmentioning

confidence: 99%

Does sperm origin affect embryo morphokinetic parameters?

Lammers

Reignier

Splingart

et al. 2015

J Assist Reprod Genet

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“…Programming the cycle can enable both medical staff and patients to navigate through daily obligations and routines. Steroid pretreatment programming is based on negative hypothalamic and hypophyseal feedback and was found to have a different pattern with oral contraceptives compared to estrogen only [6]. Oral contraceptives sharply decrease both LH and FSH values with a prolonged (5 day) washout period.…”

Section: Commentmentioning

confidence: 99%

“…Conflicting results regarding possible detrimental effects to cycle quality have been reported with OCP [2][3][4]. Luteal estrogen use was tested for its ability to affect follicular recruitment quality [5,6]. Since GnRH antagonist is gaining a tremendous popularity, we found it important to test the programming ability of an antagonist cycle modified by follicular estrogen administration, adapted to conform to specific days of the week.…”

Section: Introductionmentioning

confidence: 99%

GnRH-antagonist programming versus GnRH agonist protocol: a randomized trial

Klement

Berkovitz

Wiser

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…This approach has been widely adopted in the treatment of low responders [19,20,21,22]. Estrogen pretreatment was also recently found useful in programming GnRH antagonist cycles [23]. Oral contraceptive [24,25,26] and luteal progesterone pretreatment [24] have also been studied in the same context.…”

Section: Discussionmentioning

confidence: 99%

Controlled Ovarian Stimulation Using a Long Gonadotropin-Releasing Hormone<b> </b>Antagonist Protocol: A Proof of Concept and Feasibility Study

Weissman

Ravhon²,

Steinfeld³

et al. 2013

Gynecol Obstet Invest

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Background/Aims: To evaluate the feasibility of a long protocol of controlled ovarian stimulation prior to in vitro fertilization (IVF) and embryo transfer with a gonadotropin-releasing hormone (GnRH) antagonist used for pituitary and ovarian suppression. Methods: Thirty patients undergoing IVF/intracytoplasmic sperm injection were randomized into two groups. The control group (n = 16) received a standard flexible GnRH antagonist protocol. Ovarian stimulation consisted of 225 IU/day of recombinant follicle-stimulating hormone for 5 days, followed by 225 IU/day of human menopausal gonadotropin until human chorionic gonadotropin (hCG) administration. The study group (n = 14) received 0.25 mg of GnRH antagonist daily for 7 days, thereafter, upon confirmation of pituitary and ovarian suppression, ovarian stimulation was commenced with the same protocol as used in the control group. Hormone and follicle dynamics, as well as laboratory characteristics and cycle outcome, were compared for both groups. Results: Both groups were comparable in baseline characteristics. Pituitary and ovarian suppression were effectively achieved in 12/14 patients in the study group. The duration of ovarian stimulation and gonadotropin consumption were similar in both groups, as was also the number and size of follicles on hCG day. Conclusion: The results of our study confirm the feasibility of a long GnRH antagonist protocol. This regimen could become another option to optimize GnRH antagonist protocols, and should thus be further explored.

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Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial

Cited by 36 publications

References 25 publications

Does sperm origin affect embryo morphokinetic parameters?

Does sperm origin affect embryo morphokinetic parameters?

GnRH-antagonist programming versus GnRH agonist protocol: a randomized trial

Controlled Ovarian Stimulation Using a Long Gonadotropin-Releasing Hormone<b> </b>Antagonist Protocol: A Proof of Concept and Feasibility Study

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